2009
Central Memory CD8+ T Cells Induce Graft-versus-Host Disease and Mediate Graft-versus-Leukemia
Zheng H, Matte-Martone C, Jain D, McNiff J, Shlomchik WD. Central Memory CD8+ T Cells Induce Graft-versus-Host Disease and Mediate Graft-versus-Leukemia. The Journal Of Immunology 2009, 182: 5938-5948. PMID: 19414745, PMCID: PMC9844260, DOI: 10.4049/jimmunol.0802212.Peer-Reviewed Original ResearchConceptsMemory T cellsT cellsHost diseaseAllogeneic hemopoietic stem cell transplantationChronic phase chronic myelogenous leukemiaFunctional T-cell memoryMultiple minor histocompatibility AgsBALB/c recipientsEffector memory T cellsHemopoietic stem cell transplantationCentral memory T cellsNonmalignant host tissuesCentral memory CD8Donor T cellsMinor histocompatibility AgT-cell reconstitutionStem cell transplantationT cell memoryNaive T cellsAlphabeta T cellsChronic myelogenous leukemiaC recipientsClinical GVHDHistological diseaseLeukemia effect
2005
CD8+ Central Memory T Cells Mediate Graft-Versus-Host Disease Although Retain Graft-Versus-Leukemia Effect.
Zheng H, Matte C, Anderson B, Venkatesan S, Jain D, Shlomchik M, Shlomchik W. CD8+ Central Memory T Cells Mediate Graft-Versus-Host Disease Although Retain Graft-Versus-Leukemia Effect. Blood 2005, 106: 1312. DOI: 10.1182/blood.v106.11.1312.1312.Peer-Reviewed Original ResearchCD8 cellsMemory T cellsMore weight lossCell recipientsT cellsCM cellsWeight lossGraft-VersusHistologic GVHDLess weight lossEffector functionsBALB/c recipientsEffector memory T cellsCentral memory T cellsDay 16Central memory TClear histologic evidencePeriportal inflammatory infiltrationReconstitution of immunityDonor T cellsTime pointsMost time pointsDonor BMEarly time pointsEffective GVL
2004
Target Antigens Determine Graft-versus-Host Disease Phenotype
Kaplan DH, Anderson BE, McNiff JM, Jain D, Shlomchik MJ, Shlomchik WD. Target Antigens Determine Graft-versus-Host Disease Phenotype. The Journal Of Immunology 2004, 173: 5467-5475. PMID: 15494494, DOI: 10.4049/jimmunol.173.9.5467.Peer-Reviewed Original ResearchConceptsHost diseaseSkin diseasesBALB/c recipientsAllogeneic stem cell transplantationBALB/c miceSubset of patientsStem cell transplantationT cell repertoireKey pathologic featuresBALB/cX BALB/Host disease phenotypesCutaneous cGVHDMurine donorsSystemic GVHDC recipientsFrequent complicationCutaneous fibrosisPathologic featuresSystemic diseaseB miceCell transplantationC miceK miceImmunodominant Ag