2022
TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut‐liver crosstalk
Bhat N, Esteghamat F, Chaube BK, Gunawardhana K, Mani M, Thames C, Jain D, Ginsberg HN, Fernandes‐Hernando C, Mani A. TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut‐liver crosstalk. The FASEB Journal 2022, 36: e22185. PMID: 35133032, PMCID: PMC9624374, DOI: 10.1096/fj.202101607r.Peer-Reviewed Original ResearchConceptsGut-liver crosstalkBile synthesisDiet-induced fatty liver diseaseSmall intestineHepatic bile saltIntestinal lipid uptakePlasma bile saltsFatty liver diseaseTreatment of NASHColorectal cancer cellsBile saltsConditional knockout modelHuman NASHFatty liverLiver diseaseFXR activationClinical trialsEnterohepatic circulationTranscription factor TCF4Fl/Hepatic levelsBile acidsEndocrine regulatorLipid uptakeIntestinal epithelium
2013
Pediatric Cholestatic Disorders Approach to Pathologic Diagnosis
Morotti RA, Jain D. Pediatric Cholestatic Disorders Approach to Pathologic Diagnosis. Surgical Pathology Clinics 2013, 6: 205-225. PMID: 26838972, DOI: 10.1016/j.path.2013.03.001.Peer-Reviewed Original ResearchLiver diseaseDiagnostic challengePediatric cholestatic disordersClinical featuresPediatric groupHistopathologic featuresCholestatic disordersHistopathologic findingsPathologic diagnosisDifferential diagnosisDiagnostic modalitiesBile synthesisMolecular abnormalitiesDiagnosisDiseaseDisordersSignificant overlapPathophysiologyMolecular geneticsAbnormalities