2020
Hepatocellular neoplasms arising in genetic metabolic disorders: steatosis is common in both the tumor and background liver
Cheng L, Jain D, Kakar S, Torbenson MS, Wu TT, Yeh MM. Hepatocellular neoplasms arising in genetic metabolic disorders: steatosis is common in both the tumor and background liver. Human Pathology 2020, 108: 93-99. PMID: 33245984, DOI: 10.1016/j.humpath.2020.11.012.Peer-Reviewed Original ResearchConceptsGenetic metabolic disordersMetabolic disordersHepatocellular neoplasmsBackground liverType 1Ornithine carbamyl transferase deficiencyRare genetic metabolic disorderRare case reportBackground liver parenchymaGlycogen storage disease type 1Hereditary tyrosinemia type 1Disease type 1Tyrosinemia type 1Younger patientsRetrospective studyCase reportCommon findingLiver parenchymaSteatosisTransferase deficiencyPathological characterizationNeoplasmsTumorsDisordersPatients
2016
Therapeutic Challenges of Hepatic Mucormycosis in Hematologic Malignancy: A Case Report and Review of the Literature
Bernardo RM, Gurung A, Jain D, Malinis MF. Therapeutic Challenges of Hepatic Mucormycosis in Hematologic Malignancy: A Case Report and Review of the Literature. American Journal Of Case Reports 2016, 17: 484-489. PMID: 27406045, PMCID: PMC4948661, DOI: 10.12659/ajcr.898480.Peer-Reviewed Case Reports and Technical NotesConceptsDual antifungal therapyAntifungal therapyHepatic mucormycosisSurgical resectionClinical presentationCase reportLiver lesionsIsolated hepatic mucormycosisTransplant-associated infectionsMultiple liver lesionsCombination antifungal therapyAcute myeloid leukemiaHigh mortality rateOptimal antifungal therapyGastrointestinal involvementInduction chemotherapyNeutropenic feverAbdominal painLymphoproliferative disordersTherapeutic challengeHematologic malignanciesCommon siteMyeloid leukemiaTreatment strategiesGastrointestinal tract
2015
Trientine induced colitis during therapy for Wilson disease: a case report and review of the literature
Boga S, Jain D, Schilsky ML. Trientine induced colitis during therapy for Wilson disease: a case report and review of the literature. BMC Pharmacology And Toxicology 2015, 16: 30. PMID: 26589720, PMCID: PMC4654910, DOI: 10.1186/s40360-015-0031-z.Peer-Reviewed Original ResearchConceptsSide effectsInduced colitisZinc therapyRare side effectYear old femaleLess side effectsAutosomal recessive disorderActive ileitisSevere pancolitisTrientine therapyImpaired excretionMucosal injuryInitial treatmentNeuropsychiatric symptomsSafety profileBrain accumulationBloody diarrheaCase reportRecent diagnosisTrientine treatmentChelation therapyTrientineColitisMedical treatmentWD symptomsRecurrence of Merkel cell carcinoma in the gastrointestinal tract: a case report
Tuktamyshov R, Jain D, Ginsburg PM. Recurrence of Merkel cell carcinoma in the gastrointestinal tract: a case report. BMC Research Notes 2015, 8: 188. PMID: 25947008, PMCID: PMC4430924, DOI: 10.1186/s13104-015-1139-3.Peer-Reviewed Original ResearchConceptsMerkel cell carcinomaCell carcinomaGastrointestinal tractYear old Caucasian femaleEvaluation of anemiaAggressive skin malignancyOld Caucasian femaleIron deficiency anemiaBackgroundMerkel cell carcinomaPrimary neural cellsRegional lymphLocal recurrenceCase presentationWeSkin malignanciesCase reportCaucasian femaleCarcinomaRecurrenceNeural cellsTractAnemiaMetastasisDistant historyLymphColonoscopy
2011
Eosinophilic Myenteric Ganglionitis
Chander B, Fiedler P, Jain D. Eosinophilic Myenteric Ganglionitis. Journal Of Clinical Gastroenterology 2011, 45: 314-316. PMID: 20921901, DOI: 10.1097/mcg.0b013e3181f5978a.Peer-Reviewed Original ResearchConceptsEosinophilic myenteric ganglionitisMyenteric ganglionitisAuerbach's plexusSigmoid colonFunctional bowel obstructionOnly significant findingBowel dysmotilityFecal disimpactionRecurrent obstipationBowel obstructionClinical improvementHartmann's procedureUnknown etiologyCase reportDisease entityMuscular layerGanglionitisResectionEosinophilsPlexusColonInfiltrationSignificant findingsDysmotilityObstipation
2009
Spectrum of histologic changes in colonic biopsies in patients treated with mycophenolate mofetil
Selbst MK, Ahrens WA, Robert ME, Friedman A, Proctor DD, Jain D. Spectrum of histologic changes in colonic biopsies in patients treated with mycophenolate mofetil. Modern Pathology 2009, 22: 737-743. PMID: 19329937, DOI: 10.1038/modpathol.2009.44.Peer-Reviewed Original ResearchConceptsSolid organ transplant patientsSelf-limited colitisMycophenolate mofetilInflammatory bowel diseaseOrgan transplant patientsColonic biopsiesHistologic changesHost diseaseGastrointestinal symptomsTransplant patientsBowel diseaseArchitectural distortionMycophenolate mofetil usePaneth cell metaplasiaSolid organ transplantationMofetil useInflammatory bowelMucin depletionCell metaplasiaImmunosuppressive agentsInflammatory infiltrateHistologic patternCase reportHistologic spectrumDiagnostic difficulties
2007
Intraductal Papillary Cholangiocarcinoma Associated With von Meyenberg Complexes: A Case Report
Neto AG, Dainiak C, Qin L, Salem RR, Jain D. Intraductal Papillary Cholangiocarcinoma Associated With von Meyenberg Complexes: A Case Report. Digestive Diseases And Sciences 2007, 52: 2643-2645. PMID: 17394067, DOI: 10.1007/s10620-007-9777-5.Peer-Reviewed Original ResearchConceptsIntraductal papillary cholangiocarcinomaVon Meyenberg complexesColicky right upper quadrant painRight upper quadrant painBile duct neoplasmsFine fibrovascular coresGastric foveolar typeUpper quadrant painBiliary colicPapillary cholangiocarcinomaQuadrant painLeft hepatectomyBile ductLeft lobeCase reportFibrovascular coresPapillary frondsFoveolar typePeribiliary glandsRare caseLiver parenchymaRare formImaging studiesEnglish literatureTumors
2004
Isolated gastric malakoplakia: a case report and review of the literature.
Gustavo LC, Robert ME, Lamps LW, Lagarde SP, Jain D. Isolated gastric malakoplakia: a case report and review of the literature. Archives Of Pathology & Laboratory Medicine 2004, 128: e153-6. PMID: 15504079, DOI: 10.5858/2004-128-e153-igmacr.Peer-Reviewed Original ResearchConceptsBiopsy specimensMultiple small polypoid lesionsOccult bacterial infectionUpper gastrointestinal endoscopyExamination 12 monthsSmall polypoid lesionsHelicobacter pylori infectionMichaelis-Gutmann bodiesYersinia pseudotuberculosis infectionFundic gland polypsEosinophilic granular cytoplasmAfrican American womenConcurrent malignancyGastrointestinal malakoplakiaHistologic improvementGastric involvementGastric bodyClinical evidencePolypoid lesionsPylori infectionH pyloriHistologic findingsCase reportGastrointestinal endoscopyPolymerase chain reactionLymphoplasmacytic sclerosing pancreato-cholangitis: a case report and review of the literature.
Prasad P, Salem RR, Mangla R, Aslanian H, Jain D, Lee J. Lymphoplasmacytic sclerosing pancreato-cholangitis: a case report and review of the literature. The Yale Journal Of Biology And Medicine 2004, 77: 143-8. PMID: 15989743, PMCID: PMC2259126.Peer-Reviewed Original ResearchConceptsChronic pancreatitisAutoimmune pancreatitisPancreatic ductNon-alcoholic duct-destructive chronic pancreatitisDuct-destructive chronic pancreatitisPylorus-preserving Whipple procedureBenign formLymphoplasmacytic inflammatory infiltratePrimary sclerosing cholangitisBiliary tract diseaseAbdominal painObliterative phlebitisAutoimmune processSclerosing cholangitisWhipple procedureInflammatory infiltrateInterstitial fibrosisClinical entityCase reportTract diseasePancreatic adenocarcinomaDifferential diagnosisPancreatic carcinomaPancreaticobiliary diseasesPathological overlap
2002
Multiple Angiomyolipomata of the Liver: A Case Report
Tang LH, Hui P, Garcia-Tsao G, Salem RR, Jain D. Multiple Angiomyolipomata of the Liver: A Case Report. Modern Pathology 2002, 15: 167-171. PMID: 11850546, DOI: 10.1038/modpathol.3880509.Peer-Reviewed Original ResearchConceptsTuberous sclerosisPolymorphic human androgen receptor geneMultiple hepatic angiomyolipomasRight hepatic lobeRare benign tumorSurgical resection specimenHuman androgen receptor geneAndrogen receptor geneMultiple angiomyolipomasClinical evidenceHepatic angiomyolipomaHepatic lobeResection specimenMultiple lesionsCase reportHistologic diagnosisHistologic examinationBenign tumorsSmooth muscleAngiomyolipomaUnusual caseAdipose tissuePolyclonal lesionsClonal proliferationCorresponding lesions