2023
Focal nodular hyperplasia–like nodules arising in the setting of hepatic vascular disorders with portosystemic shunting show β-catenin activation
Umetsu S, Joseph N, Cho S, Morotti R, Deshpande V, Jain D, Kakar S. Focal nodular hyperplasia–like nodules arising in the setting of hepatic vascular disorders with portosystemic shunting show β-catenin activation. Human Pathology 2023, 142: 20-26. PMID: 37806391, DOI: 10.1016/j.humpath.2023.09.010.Peer-Reviewed Original ResearchConceptsHepatic vascular disordersFocal nodular hyperplasiaFNH-like nodulesHepatocellular adenomaVascular disordersHepatocellular carcinomaΒ-catenin activationPortosystemic shuntRegenerative nodulesFocal nodular hyperplasia-like nodulesPost-Fontan procedureGlutamine synthetase stainingAbernethy malformationLiver resectionPortosystemic shuntingHistologic featuresMalignant neoplasmsNodular lesionsVascular diseaseDuctular reactionNodular hyperplasiaNodular architectureHepatocellular nodulesBenign lesionsFibrous septa
2021
Thick Fibrous Septa on Liver Biopsy Specimens Predict the Development of Decompensation in Patients With Compensated Cirrhosis
Jain D, Sreenivasan P, Inayat I, Deng Y, Ciarleglio MM, Garcia-Tsao G. Thick Fibrous Septa on Liver Biopsy Specimens Predict the Development of Decompensation in Patients With Compensated Cirrhosis. American Journal Of Clinical Pathology 2021, 156: 802-809. PMID: 33940622, PMCID: PMC8512277, DOI: 10.1093/ajcp/aqab024.Peer-Reviewed Original ResearchConceptsDevelopment of decompensationThick fibrous septaSeptal widthCompensated cirrhosisClinical decompensationSeptal thicknessFibrous septaEnd-stage liver disease (MELD) scorePrimary end pointSignificant portal hypertensionLiver Disease scoreLiver biopsy specimenLiver biopsy specimensNodule sizeCirrhosis decompensationHistologic cirrhosisCompensated patientsPortal hypertensionIndependent predictorsLiver biopsyCommon etiologyWorse prognosisBiopsy specimenBiopsy specimensUnivariate analysis
2012
Quantitative histological‐hemodynamic correlations in cirrhosis
Sethasine S, Jain D, Groszmann RJ, Garcia‐Tsao G. Quantitative histological‐hemodynamic correlations in cirrhosis. Hepatology 2012, 55: 1146-1153. PMID: 22109744, PMCID: PMC3721182, DOI: 10.1002/hep.24805.Peer-Reviewed Original ResearchConceptsSignificant portal hypertensionPortal hypertensionFibrosis areaLiver biopsyCirrhotic nodulesNodule sizeHVPG measurementPortal pressureIndependent predictorsSeptal thicknessFibrous septaBiopsyPathophysiological implicationsCirrhosisHVPGPatientsSemiquantitative analysisNodulesOnly parameterHypertensionNumber of nodules
2008
Different cytokeratin and neuronal cell adhesion molecule staining patterns in focal nodular hyperplasia and hepatic adenoma and their significance
Iyer A, Robert ME, Bifulco CB, Salem RR, Jain D. Different cytokeratin and neuronal cell adhesion molecule staining patterns in focal nodular hyperplasia and hepatic adenoma and their significance. Human Pathology 2008, 39: 1370-1377. PMID: 18602664, PMCID: PMC3738023, DOI: 10.1016/j.humpath.2008.01.015.Peer-Reviewed Original ResearchConceptsFocal nodular hyperplasiaNeuronal cell adhesion moleculeHepatic adenomaNodular hyperplasiaCell adhesion moleculeCytokeratin 7Cytokeratin 19Biliary epitheliumProgenitor/stem cellsAdhesion moleculesTelangiectatic focal nodular hyperplasiaCytokeratin 7 stainsStem cellsRare positivityAbnormal perfusionBile ductHepatocellular carcinomaStrong positivityHepatic endotheliumImmunohistochemical analysisModerate stainingFibrous septaDifferent cytokeratinsHyperplasiaAdenomas