2015
Comparison of 5 Immunohistochemical Markers of Hepatocellular Differentiation for the Diagnosis of Hepatocellular Carcinoma
Nguyen T, Phillips D, Jain D, Torbenson M, Wu TT, Yeh MM, Kakar S. Comparison of 5 Immunohistochemical Markers of Hepatocellular Differentiation for the Diagnosis of Hepatocellular Carcinoma. Archives Of Pathology & Laboratory Medicine 2015, 139: 1028-34. PMID: 26230595, DOI: 10.5858/arpa.2014-0479-oa.Peer-Reviewed Original ResearchConceptsHep Par 1Polyclonal carcinoembryonic antigenArginase-1Hepatocellular carcinomaGlypican-3Carcinoembryonic antigenPAR-1Immunohistochemical markersSensitive markerHepatocellular differentiationLiver biopsyCarcinomaBest overall sensitivityHepatocellular markersLimited tissueAntigen 1Overall sensitivityDiagnosisCombined useReliable diagnosisPositive resultsMarkersLimited role
2013
Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma
Krings G, Ramachandran R, Jain D, Wu TT, Yeh MM, Torbenson M, Kakar S. Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma. Modern Pathology 2013, 26: 782-791. PMID: 23348905, DOI: 10.1038/modpathol.2012.243.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, ScirrhousAdultAgedArginaseBile Duct NeoplasmsBile Ducts, IntrahepaticBiomarkers, TumorCarcinoma, HepatocellularChi-Square DistributionCholangiocarcinomaDiagnosis, DifferentialDiagnostic ErrorsFemaleGlypicansHumansImmunohistochemistryLiver NeoplasmsMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsConceptsScirrhous hepatocellular carcinomaClassical hepatocellular carcinomaHepatocellular carcinomaHepatocellular carcinoma casesGlypican-3Carcinoma casesMarked stromal fibrosisEpithelial cell adhesion moleculeMetastatic adenocarcinomaIntrahepatic cholangiocarcinomaStromal fibrosisCytokeratin 7Needle biopsyFrequent positivityCell adhesion moleculeHepPar-1Immunohistochemical pitfallsMorphological subtypesCarcinomaAdenocarcinomaHepatocellular differentiationCytokeratin 19Erroneous diagnosisReliable markerAdhesion molecules