2023
CRP Versus SAA for Identification of Inflammatory Hepatic Adenomas
Soon G, Yasir S, Jain D, Kakar S, Wu T, Yeh M, Torbenson M, Chen Z. CRP Versus SAA for Identification of Inflammatory Hepatic Adenomas. Applied Immunohistochemistry & Molecular Morphology 2023, 31: 590-595. PMID: 37698958, DOI: 10.1097/pai.0000000000001155.Peer-Reviewed Original ResearchConceptsC-reactive proteinFocal nodular hyperplasiaHepatic adenomaInflammatory hepatic adenomaInflammatory adenomasNodular hyperplasiaH-scorePositive C-reactive proteinBeta-catenin activationProportion of casesInflammatory hepatocellular adenomaGlutamine synthetase stainingComplication riskRetrospective studyResection specimensPatient managementHepatocellular adenomaImmunohistochemical stainingSerum amyloidPositive stainingControl groupAdenomasIntense stainingMolecular classificationCRP staining
2022
Alternative lengthening of telomeres in primary hepatic neoplasms
Yasir S, Thompson S, Chen Z, Knudson R, Knutson D, Kloft-Nelson S, Graham R, Jain D, Simon S, Wu T, Torbenson M. Alternative lengthening of telomeres in primary hepatic neoplasms. Human Pathology 2022, 131: 79-86. PMID: 36370823, PMCID: PMC10756352, DOI: 10.1016/j.humpath.2022.11.003.Peer-Reviewed Original ResearchConceptsPrimary hepatic neoplasmsPrimary hepatic angiosarcomaHepatocellular carcinomaHepatic neoplasmsHepatic angiosarcomaFibrolamellar carcinomaEpithelial tumorsNuclear pleomorphismFrequency of ALTStromal-epithelial tumorPrimary hepatic tumorsHepatocellular carcinoma componentMarked nuclear pleomorphismSoft tissue tumorsRare carcinosarcomaEmbryonal sarcomaEpithelioid hemangioendotheliomaDuct adenomaHilar cholangiocarcinomaCarcinoma componentHepatic adenomaHepatic tumorsTissue tumorsHepatocellular adenomaRhabdoid tumorHepatic Adenomas in Patients 60 and Older Are Enriched for HNF1A Inactivation and Malignant Transformation
Yasir S, Chen ZE, Jain D, Kakar S, Wu TT, Yeh MM, Torbenson MS. Hepatic Adenomas in Patients 60 and Older Are Enriched for HNF1A Inactivation and Malignant Transformation. The American Journal Of Surgical Pathology 2022, 46: 786-792. PMID: 35383587, PMCID: PMC9469468, DOI: 10.1097/pas.0000000000001892.Peer-Reviewed Original ResearchConceptsPersons 60 yearsAtypical histologic featuresHepatic adenomaMalignant transformationControl groupOlder aged personInflammatory adenomasUnclassified adenomasHistologic featuresGroups of adenomasAged personsEarly malignant transformationYears of agePersons age 60Patients 60Persons 60Lipofuscin depositionMyxoid changeAge 60AdenomasBeta-catenin activationBeta-catenin pathwayAgeWomenMore years
2019
Identification of key challenges in liver pathology: data from a multicenter study of extramural consults
Torbenson MS, Arnold CA, Graham RP, Jain D, Kakar S, Lam-Himlin DM, Naini BV, Wu TT, Yeh M. Identification of key challenges in liver pathology: data from a multicenter study of extramural consults. Human Pathology 2019, 87: 75-82. PMID: 30857968, DOI: 10.1016/j.humpath.2019.03.001.Peer-Reviewed Original ResearchConceptsLiver pathologyEtiology of cirrhosisFatty liver diseasePrimary biliary cirrhosisDiagnosis of malignancyFocal nodular hyperplasiaLiver casesAutoimmune hepatitisHepatitic patternBiliary cirrhosisLiver diseaseMetastatic malignancyMulticenter studyHepatic adenomaNodular hyperplasiaBenign tumorsConsult serviceMalignant tumorsHepatocellular carcinomaAcademic centersSpecific diagnosisTumor pathologyTumor typesConsultant diagnosesPatient care
2018
A practical diagnostic approach to hepatic masses.
Vyas M, Jain D. A practical diagnostic approach to hepatic masses. Indian Journal Of Pathology And Microbiology 2018, 61: 2-17. PMID: 29567877, DOI: 10.4103/ijpm.ijpm_578_17.Peer-Reviewed Original ResearchConceptsDifferential diagnosisHepatic massCorrect diagnosisRight diagnosisBackground liver diseaseUnknown primary siteFocal nodular hyperplasiaHepatic mass lesionsPractical diagnostic approachList of antibodiesNonhepatocellular originProper workupClinical presentationHepatocellular originLiver diseaseHistologic featuresPrimary lesionClinicopathological correlationHepatic adenomaVascular tumorsMass lesionNonepithelial neoplasmsCommon siteNeedle biopsyNodular hyperplasia
2013
Diagnostic Approach to Hepatic Mass Lesions and Role of Immunohistochemistry
Marginean EC, Gown AM, Jain D. Diagnostic Approach to Hepatic Mass Lesions and Role of Immunohistochemistry. Surgical Pathology Clinics 2013, 6: 333-365. PMID: 26838978, DOI: 10.1016/j.path.2013.03.005.Peer-Reviewed Original ResearchFocal nodular hyperplasiaHepatic mass lesionsMass lesionHepatocellular carcinomaHepatic adenomaDifferential diagnosisDiagnostic approachCommon mass lesionsPrimary hepatic neoplasmsRole of immunohistochemistryCommon malignant tumorPractical diagnostic approachYounger patientsHepatic massMacroregenerative nodulesNoncirrhotic liverNodular hyperplasiaCirrhotic liverImmunohistochemical stainsMalignant tumorsHepatic neoplasmsMalignant lesionsClinical practiceDysplastic nodulesLesions
2012
Reticulin Loss in Benign Fatty Liver
Singhi AD, Jain D, Kakar S, Wu TT, Yeh MM, Torbenson M. Reticulin Loss in Benign Fatty Liver. The American Journal Of Surgical Pathology 2012, 36: 710-715. PMID: 22498821, DOI: 10.1097/pas.0b013e3182495c73.Peer-Reviewed Original ResearchConceptsLoss of reticulinFatty changeHepatic adenomaHepatocellular carcinomaReticulin stainingDiagnostic pitfallsImportant diagnostic pitfallMarked steatosisModerate steatosisNonalcoholic steatohepatitisMild steatosisFibrosis stageReticulin stainNumber of fociLiver tissueBenign fatty liverCases of steatohepatitisDegree of steatosisDegree of inflammationNon-neoplastic liver tissueAmount of steatosisMarked fatty changeCases of steatosisFine needle aspiratesFatty liver
2009
Diagnostic use of cytokeratins, CD34, and neuronal cell adhesion molecule staining in focal nodular hyperplasia and hepatic adenoma
Ahmad I, Iyer A, Marginean CE, Yeh MM, Ferrell L, Qin L, Bifulco CB, Jain D. Diagnostic use of cytokeratins, CD34, and neuronal cell adhesion molecule staining in focal nodular hyperplasia and hepatic adenoma. Human Pathology 2009, 40: 726-734. PMID: 19157505, DOI: 10.1016/j.humpath.2008.10.018.Peer-Reviewed Original ResearchConceptsTelangiectatic focal nodular hyperplasiaFocal nodular hyperplasia casesFocal nodular hyperplasiaNeuronal cell adhesion moleculeHepatic adenomaNodular hyperplasiaCytokeratin 7Cytokeratin 19Hyperplasia casesNeedle biopsyCell adhesion moleculeBile ductAdhesion moleculesCD34 stainCytokeratin 7 stainingCorresponding resection specimensDiagnostic useParaffin-embedded sectionsDistinct staining patternsProspective studyResected specimensHistologic featuresResection specimenResection specimensCorresponding resections
2008
Different cytokeratin and neuronal cell adhesion molecule staining patterns in focal nodular hyperplasia and hepatic adenoma and their significance
Iyer A, Robert ME, Bifulco CB, Salem RR, Jain D. Different cytokeratin and neuronal cell adhesion molecule staining patterns in focal nodular hyperplasia and hepatic adenoma and their significance. Human Pathology 2008, 39: 1370-1377. PMID: 18602664, PMCID: PMC3738023, DOI: 10.1016/j.humpath.2008.01.015.Peer-Reviewed Original ResearchConceptsFocal nodular hyperplasiaNeuronal cell adhesion moleculeHepatic adenomaNodular hyperplasiaCell adhesion moleculeCytokeratin 7Cytokeratin 19Biliary epitheliumProgenitor/stem cellsAdhesion moleculesTelangiectatic focal nodular hyperplasiaCytokeratin 7 stainsStem cellsRare positivityAbnormal perfusionBile ductHepatocellular carcinomaStrong positivityHepatic endotheliumImmunohistochemical analysisModerate stainingFibrous septaDifferent cytokeratinsHyperplasiaAdenomas