2022
The many faces and pathologic diagnostic challenges of autoimmune hepatitis
Zhang X, Jain D. The many faces and pathologic diagnostic challenges of autoimmune hepatitis. Human Pathology 2022, 132: 114-125. PMID: 35753409, DOI: 10.1016/j.humpath.2022.06.019.Peer-Reviewed Original ResearchConceptsAutoimmune hepatitisHistological featuresLiver diseaseAcute-onset autoimmune hepatitisDiagnosis of AIHEnd-stage liver diseaseChronic inflammatory liver diseasePathologic diagnostic challengeFatal liver failureInflammatory liver diseaseTypical histological featuresCareful clinicopathological correlationRoutine clinical practiceMajor differential diagnosisImmunosuppressive treatmentLiver histologySpecific autoantibodiesLiver failurePrompt diagnosisHistological presentationClinicopathological correlationInternational Working GroupPathological featuresDiagnostic challengeHistopathologic spectrumConsensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group
Lohse AW, Sebode M, Bhathal PS, Clouston AD, Dienes HP, Jain D, Gouw ASH, Guindi M, Kakar S, Kleiner DE, Krech T, Lackner C, Longerich T, Saxena R, Terracciano L, Washington K, Weidemann S, Hübscher SG, Tiniakos D. Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group. Liver International 2022, 42: 1058-1069. PMID: 35230735, DOI: 10.1111/liv.15217.Peer-Reviewed Original ResearchConceptsAutoimmune hepatitisChronic autoimmune hepatitisLobular hepatitisLymphoplasmacytic hepatitisInflammatory changesLiver diseaseHistological featuresHistological criteriaConsensus criteriaInternational consensus criteriaExpert liver pathologistsDelphi panel approachChronic presentationAcute presentationLiver biopsyHistological diagnosisHistopathological diagnosisLiver pathologistsLiver pathologyConsensus statementConsensus recommendationsHepatitisPathology groupDisease severityPeriportal region
2013
Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma
Joseph NM, Ferrell LD, Jain D, Torbenson MS, Wu TT, Yeh MM, Kakar S. Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma. Modern Pathology 2013, 27: 62-72. PMID: 23807780, DOI: 10.1038/modpathol.2013.114.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Liver CellAdolescentAdultAgedBiomarkers, TumorBiopsyChildChild, PreschoolC-Reactive ProteinDiagnosis, DifferentialDiagnostic ErrorsFemaleFocal Nodular HyperplasiaGlutamate-Ammonia LigaseHumansImmunohistochemistryInflammation MediatorsLiver NeoplasmsMaleMiddle AgedPredictive Value of TestsSerum Amyloid A ProteinYoung AdultConceptsSerum amyloid-associated proteinFocal nodular hyperplasiaAmyloid-associated proteinsInflammatory hepatocellular adenomaNodular hyperplasiaHepatocellular adenomaStaining patternDuctular reactionFibrous stromaFocal nodular hyperplasia casesMap-like patternOverlapping histological featuresGlutamine synthetase stainingHistological featuresProtein immunohistochemistryHyperplasia casesIndeterminate lesionsPositive stainingHyperplasiaDiagnostic utilityAdenomasBlood vesselsFrequent overlapStainingDiagnostic errors
2008
Chromosomal changes in fibrolamellar hepatocellular carcinoma detected by array comparative genomic hybridization
Kakar S, Chen X, Ho C, Burgart LJ, Sahai V, Dachrut S, Yabes A, Jain D, Ferrell LD. Chromosomal changes in fibrolamellar hepatocellular carcinoma detected by array comparative genomic hybridization. Modern Pathology 2008, 22: 134-141. PMID: 18997738, DOI: 10.1038/modpathol.2008.178.Peer-Reviewed Original ResearchConceptsConventional hepatocellular carcinomaFibrolamellar hepatocellular carcinomaHepatocellular carcinomaFibrolamellar carcinomaChromosomal abnormalitiesCommon abnormalityChromosomal changesClinicopathologic featuresTumor sizeRare subtypeAbnormal casesHistological featuresFavorable outcomeNormal resultsBetter survivalComparative genomic hybridization analysisCarcinomaCytogenetic abnormalitiesGenomic hybridization analysisAbnormalitiesCytogenetic aberrationsArray comparative genomic hybridizationComparative genomic hybridizationMean numberPatients