2011
Graft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells
Li H, Matte-Martone C, Tan HS, Venkatesan S, McNiff J, Demetris AJ, Jain D, Lakkis F, Rothstein D, Shlomchik WD. Graft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells. The Journal Of Immunology 2011, 186: 230-241. PMID: 21098219, PMCID: PMC5822434, DOI: 10.4049/jimmunol.1002965.Peer-Reviewed Original ResearchConceptsT cell responsesHost APCsHost diseaseAPC maturationT cellsAllogeneic hematopoietic stem cell transplantationAlloreactive donor T cellsCell responsesAdaptive T cell responsesHematopoietic stem cell transplantationHost hematopoietic cellsHost IL-12Donor T cellsAlloreactive T cellsStem cell transplantationT cell productionType I IFNInnate signaling pathwaysPattern recognition receptorsHematopoietic cellsMyD88/IL-12Cell transplantationIL-1βInflammatory cytokines
2010
Recipient B Cells Are Not Required for Graft-Versus-Host Disease Induction
Matte-Martone C, Wang X, Anderson B, Jain D, Demetris AJ, McNiff J, Shlomchik MJ, Shlomchik WD. Recipient B Cells Are Not Required for Graft-Versus-Host Disease Induction. Transplantation And Cellular Therapy 2010, 16: 1222-1230. PMID: 20338255, PMCID: PMC3135976, DOI: 10.1016/j.bbmt.2010.03.015.Peer-Reviewed Original ResearchConceptsRecipient B cellsAntigen presenting cellsB cellsAllogeneic hematopoietic stem cell transplantationB cell-deficient recipientsImportant antigen presenting cellsRecipient antigen presenting cellsAllogeneic bone marrow transplantationHematopoietic stem cell transplantationCD8-mediated GVHDHost disease inductionB-cell depletionAntibody-mediated depletionHost B cellsCD20 monoclonal antibodyStem cell transplantationT cell responsesBone marrow transplantationGraft-VersusAPC subsetsHost diseaseMarrow transplantationCell depletionCell transplantationPresenting cells