Mycophenolate Mofetil-induced Colitis in Children
Phatak UP, Seo-Mayer P, Jain D, Selbst M, Husain S, Pashankar DS. Mycophenolate Mofetil-induced Colitis in Children. Journal Of Clinical Gastroenterology 2009, 43: 967-969. PMID: 19609219, DOI: 10.1097/mcg.0b013e3181a8754d.Peer-Reviewed Original ResearchConceptsMycophenolate mofetilSevere colitisMild gastrointestinal side effectsPediatric renal transplant patientsWithdrawal of MMFMaintenance of immunosuppressionRenal transplant patientsInflammatory bowel diseaseGastrointestinal side effectsCause of diarrheaMMF therapyHost diseaseTransplant patientsBowel diseaseColonic biopsiesHistologic featuresPatient 1Patient 2Histologic findingsComplete resolutionSide effectsColitisPatientsCausal associationMofetilSpectrum of histologic changes in colonic biopsies in patients treated with mycophenolate mofetil
Selbst MK, Ahrens WA, Robert ME, Friedman A, Proctor DD, Jain D. Spectrum of histologic changes in colonic biopsies in patients treated with mycophenolate mofetil. Modern Pathology 2009, 22: 737-743. PMID: 19329937, DOI: 10.1038/modpathol.2009.44.Peer-Reviewed Original ResearchConceptsSolid organ transplant patientsSelf-limited colitisMycophenolate mofetilInflammatory bowel diseaseOrgan transplant patientsColonic biopsiesHistologic changesHost diseaseGastrointestinal symptomsTransplant patientsBowel diseaseArchitectural distortionMycophenolate mofetil usePaneth cell metaplasiaSolid organ transplantationMofetil useInflammatory bowelMucin depletionCell metaplasiaImmunosuppressive agentsInflammatory infiltrateHistologic patternCase reportHistologic spectrumDiagnostic difficulties