2022
Microangiopathic Hemolytic Anemia Is a Late and Fatal Complication of Gastric Signet Ring Cell Carcinoma: A Systematic Review and Case-Control Study
Lam R, Tarangelo N, Wang R, Horibe M, Grimshaw AA, Jain D, Haffar S, Bazerbachi F, Kunz PL, Li DK. Microangiopathic Hemolytic Anemia Is a Late and Fatal Complication of Gastric Signet Ring Cell Carcinoma: A Systematic Review and Case-Control Study. The Oncologist 2022, 27: 751-759. PMID: 35589098, PMCID: PMC9438916, DOI: 10.1093/oncolo/oyac093.Peer-Reviewed Original ResearchMeSH KeywordsAnemia, HemolyticCarcinoma, Signet Ring CellCase-Control StudiesHumansPrognosisStomach NeoplasmsConceptsGastric signet ring cell carcinomaSignet ring cell carcinomaMicroangiopathic hemolytic anemiaHemolytic anemiaCell carcinomaMultivariable Cox proportional hazards regression modelingCox proportional hazards regression modelingSystematic reviewRare paraneoplastic syndromeStage-matched casesEnd Results (SEER) databaseLate-stage complicationsRisk of mortalityCase-control studyBone painParaneoplastic syndromeFatal complicationMedian survivalMetastatic diseaseOverall survivalLymph nodesIndex presentationPrognostic featuresResults databasePooled cohort
2015
Hepatic Arteriolosclerosis
Balakrishnan M, Garcia-Tsao G, Deng Y, Ciarleglio M, Jain D. Hepatic Arteriolosclerosis. The American Journal Of Surgical Pathology 2015, 39: 1000-1009. PMID: 25786083, PMCID: PMC4466001, DOI: 10.1097/pas.0000000000000419.Peer-Reviewed Original ResearchConceptsPresence of diabetesBody mass indexDiabetic patientsSinusoidal fibrosisMass indexHepatitis C virus (HCV) infection statusHigher average body mass indexAverage body mass indexAbsence of steatosisHepatic sinusoidal fibrosisSmall-vessel complicationsPrevalence of hypertensionRight heart failureLiver biopsy findingsSignificant alcohol useAdjusted odds ratioTime of biopsyComplications of diabetesPattern of fibrosisType 2 diabetesAvailable clinical informationCase-control studyVirus infection statusForms of steatohepatitisGlycogenic hepatopathy
2011
Genetic Effects and Modifiers of Radiotherapy and Chemotherapy on Survival in Pancreatic Cancer
Zeng H, Yu H, Lu L, Jain D, Kidd MS, Saif MW, Chanock SJ, Hartge P, Risch H. Genetic Effects and Modifiers of Radiotherapy and Chemotherapy on Survival in Pancreatic Cancer. Pancreas 2011, 40: 657-663. PMID: 21487324, PMCID: PMC3116071, DOI: 10.1097/mpa.0b013e31821268d1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overATP Binding Cassette Transporter, Subfamily G, Member 2ATP-Binding Cassette TransportersCase-Control StudiesConnecticutDihydrouracil Dehydrogenase (NADP)FemaleGenetic MarkersGenetic VariationGenome-Wide Association StudyHumansMaleMiddle AgedNeoplasm ProteinsPancreatic NeoplasmsPolymorphism, Single NucleotidePrognosisProportional Hazards ModelsSerpinsSurvival AnalysisTreatment OutcomeConceptsPancreatic cancerOverall survivalCancer survivalProportional hazards regression modelsSurvival of patientsPopulation-based studyPancreatic cancer survivalHazards regression modelsGerm-line genetic variationEvidence of associationClinical outcomesCancer patientsTreatment outcomesTreatment responseSignificant associationPatientsCancerPrevious genome-wide association study dataRadiotherapyPutative markerGenetic polymorphismsSurvivalDPYD geneChemotherapyEvidence of interaction
2003
Role of Interstitial Cells of Cajal in Motility Disorders of the Bowel
Jain D, Moussa K, Tandon M, Culpepper-Morgan J, Proctor DD. Role of Interstitial Cells of Cajal in Motility Disorders of the Bowel. The American Journal Of Gastroenterology 2003, 98: ajg2003146. PMID: 12650797, DOI: 10.1111/j.1572-0241.2003.07295.x.Peer-Reviewed Original ResearchConceptsMechanical bowel obstructionMotility disordersBowel obstructionNormal controlsInterstitial cellsPolyclonal c-kit antibodyAge-matched normal controlsBowel motility disordersNeonatal meconium ileusSpecific histological changesAdministration of drugsIndirect immunoperoxidase methodC-kit antibodyBowel dysmotilityMechanical obstructionSystemic disordersMeconium ileusC-kit receptorHistological changesNeuropathic formPatientsPatchy areasImmunoperoxidase methodMasson's trichromeIntestinal tract