2019
In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease
Morin-Zorman S, Wysocki C, Zhu J, Li H, Zorman S, Matte-Martone C, Kisanga E, McNiff J, Jain D, Gonzalez D, Rothstein DM, Lakkis FG, Haberman A, Shlomchik WD. In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease. Blood Advances 2019, 3: 2082-2092. PMID: 31296496, PMCID: PMC6650737, DOI: 10.1182/bloodadvances.2019000227.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCD11c AntigenCell CommunicationDendritic CellsDisease Models, AnimalFluorescent Antibody TechniqueGene ExpressionGenes, ReporterGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHistocompatibility Antigens Class IImmunophenotypingLymphocyte DepletionMiceMice, TransgenicProtein BindingReceptors, Antigen, T-CellSkin DiseasesT-Lymphocyte SubsetsT-LymphocytesTransplantation, HomologousConceptsDonor dendritic cellsCD8 cellsT cellsGVHD lesionsHost diseaseCD4 cellsDendritic cellsAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationMajority of CD4Dynamics of CD4Stem cell transplantationCutaneous graftAntibody infusionCell transplantationMyeloid cellsIntravital microscopyAcute deletionMajor causeLesionsTarget tissuesCD103CD4InfusionMHCII
2004
Donor APCs are required for maximal GVHD but not for GVL
Matte CC, Liu J, Cormier J, Anderson BE, Athanasiadis I, Jain D, McNiff J, Shlomchik WD. Donor APCs are required for maximal GVHD but not for GVL. Nature Medicine 2004, 10: 987-992. PMID: 15286785, DOI: 10.1038/nm1089.Peer-Reviewed Original ResearchConceptsDonor antigen-presenting cellsAntigen-presenting cellsCD8 cellsMouse modelDonor major histocompatibility complex (MHC) class IBone marrowDonor-derived antigen-presenting cellsChronic phase chronic myelogenous leukemiaHematopoietic antigen-presenting cellsRecipient antigen-presenting cellsHost antigen-presenting cellsMajor histocompatibility complex class IAlloreactive CD8 cellsRecipients of MHCHistocompatibility complex class IDonor-derived cellsMinor histocompatibility antigensChronic myelogenous leukemiaDeficient bone marrowComplex class IHost diseaseGVHDHistocompatibility antigensMyelogenous leukemiaInitial priming