2016
αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor
Lu H, Wang T, Li J, Fedele C, Liu Q, Zhang J, Jiang Z, Jain D, Iozzo RV, Violette SM, Weinreb PH, Davis RJ, Gioeli D, FitzGerald TJ, Altieri DC, Languino LR. αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor. Cancer Research 2016, 76: 5163-5174. PMID: 27450452, PMCID: PMC5012867, DOI: 10.1158/0008-5472.can-16-0543.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, NeoplasmCell Line, TumorDisease Models, AnimalFlow CytometryFluorescent Antibody TechniqueGene Knockdown TechniquesHumansImmunohistochemistryIntegrinsMaleMiceMice, KnockoutMitogen-Activated Protein Kinase 8Prostatic Neoplasms, Castration-ResistantReceptors, AndrogenSignal TransductionConceptsΑvβ6 expressionAndrogen receptorProstate cancerΑvβ6 integrinCastrate-resistant prostate cancerProstate cancer mouse modelAbsence of androgenFurther clinical developmentProstate cancer therapyCancer mouse modelNormal prostatic epitheliumProstate cancer progressionΑv-containing integrinsMajor therapeutic targetUpregulation of survivinActivation of JNK1Androgen ablationDownstream kinase activationMechanisms of resistanceProstatic adenocarcinomaInvolvement of p38Preclinical resultsMouse modelProstatic epitheliumClinical development
2004
Inhibin Expression in Ovarian-type Stroma in Mucinous Cystic Neoplasms of the Pancreas
Yeh MM, Tang LH, Wang, Robert ME, Zheng W, Jain D. Inhibin Expression in Ovarian-type Stroma in Mucinous Cystic Neoplasms of the Pancreas. Applied Immunohistochemistry & Molecular Morphology 2004, 12: 148-152. PMID: 15354741, DOI: 10.1097/00129039-200406000-00009.Peer-Reviewed Original ResearchConceptsOvarian-type stromaMucinous cystic neoplasmCases of MCNProgesterone receptorSolid pseudopapillary neoplasmTheca-like cellsEstrogen receptorCystic neoplasmsPseudopapillary neoplasmStandard indirect immunoperoxidase methodPancreatic mucinous cystic neoplasmIntraductal papillary mucinous tumorMucinous cystic tumorsOvarian stromal tissueComplex hormonal interactionsNormal pancreatic tissueIndirect immunoperoxidase methodInhibin expressionPR positivityMucinous tumorsFemale patientsCystic tumorOvarian stromaSerous cystadenomaAlpha-inhibin
2002
Multiple Angiomyolipomata of the Liver: A Case Report
Tang LH, Hui P, Garcia-Tsao G, Salem RR, Jain D. Multiple Angiomyolipomata of the Liver: A Case Report. Modern Pathology 2002, 15: 167-171. PMID: 11850546, DOI: 10.1038/modpathol.3880509.Peer-Reviewed Original ResearchConceptsTuberous sclerosisPolymorphic human androgen receptor geneMultiple hepatic angiomyolipomasRight hepatic lobeRare benign tumorSurgical resection specimenHuman androgen receptor geneAndrogen receptor geneMultiple angiomyolipomasClinical evidenceHepatic angiomyolipomaHepatic lobeResection specimenMultiple lesionsCase reportHistologic diagnosisHistologic examinationBenign tumorsSmooth muscleAngiomyolipomaUnusual caseAdipose tissuePolyclonal lesionsClonal proliferationCorresponding lesions