2008
Bone Marrow–derived Cells and Stem Cells in Lung Repair
Krause DS. Bone Marrow–derived Cells and Stem Cells in Lung Repair. Annals Of The American Thoracic Society 2008, 5: 323-327. PMID: 18403327, PMCID: PMC2645242, DOI: 10.1513/pats.200712-169dr.Peer-Reviewed Original ResearchConceptsMarrow-derived epithelial cellsEpithelial cellsBM cellsTissue injuryBone marrow-derived cellsBM-derived cellsMarrow-derived cellsPotential clinical utilityBronchiolar epithelial cellsType II pneumocytesLung damageTracheal epithelial cellsLung repairClinical utilityGI tractBone marrowTissue damagePeer-reviewed studiesNonhematopoietic cell typesBeneficial effectsPotential mechanismsTissue repairLungInjuryTissue microenvironment
2005
Bone Marrow Transplantation Can Attenuate the Progression of Mesangial Sclerosis
Guo J, Schedl A, Krause DS. Bone Marrow Transplantation Can Attenuate the Progression of Mesangial Sclerosis. Stem Cells 2005, 24: 406-415. PMID: 16150922, DOI: 10.1634/stemcells.2005-0139.Peer-Reviewed Original ResearchConceptsBone marrow transplantationBM transplantationWild-type BMMesangial sclerosisMarrow transplantationBeneficial effectsLong-term beneficial effectsLower urinary albuminBM-derived cellsDonor BM cellsWild-type recipientsSignificant beneficial effectLong-term improvementProlongation of lifespanMaximal ameliorationRenal diseaseUrinary albuminRenal parenchymaBM cellsTherapeutic effectAlbuminuriaTransplantationTherapeutic potentialLethal doseHeterozygous mice