2022
Longitudinal single-cell analysis of a patient receiving adoptive cell therapy reveals potential mechanisms of treatment failure
Qu R, Kluger Y, Yang J, Zhao J, Hafler D, Krause D, Bersenev A, Bosenberg M, Hurwitz M, Lucca L, Kluger H. Longitudinal single-cell analysis of a patient receiving adoptive cell therapy reveals potential mechanisms of treatment failure. Molecular Cancer 2022, 21: 219. PMID: 36514045, PMCID: PMC9749221, DOI: 10.1186/s12943-022-01688-5.Peer-Reviewed Original ResearchConceptsAdoptive cell therapySingle-cell analysisDepth single-cell analysisSingle-cell RNAACT productsDisease progressionT-cell receptor sequencingCell therapyFamily genesFeatures of exhaustionMultiple tumor typesCell expansionGenesNew clonotypesTIL preparationsClonal cell expansionCytokine therapyTreatment failureSerial bloodClonesEffector functionsSerial samplesTumor typesCellular therapyTherapy
2001
Chapter 21 Mononuclear Cell Preparations
Valleca M, Debelak J, Krause D. Chapter 21 Mononuclear Cell Preparations. 2001, 179-186. DOI: 10.1016/b978-012348775-9/50072-7.ChaptersDonor leukocyte infusionMononuclear cell preparationsCell preparationsPost-transplant settingRelapse of malignancySpecific immunologic functionsCell populationsLocal institutional review boardAllogeneic cell therapyInstitutional review boardLeukocyte infusionAdoptive immunotherapyDendritic cellsTransplant settingAbsolute indicationImmunologic functionPatient's physicianT lymphocytesClinical protocolsCell therapyUnmanipulated cellsReview boardInfusionConsent formDonor cells