2008
Physiological variations of stem cell factor and stromal‐derived factor‐1 in murine models of liver injury and regeneration
Swenson ES, Kuwahara R, Krause DS, Theise ND. Physiological variations of stem cell factor and stromal‐derived factor‐1 in murine models of liver injury and regeneration. Liver International 2008, 28: 308-318. PMID: 18290773, PMCID: PMC2846401, DOI: 10.1111/j.1478-3231.2007.01659.x.Peer-Reviewed Original ResearchConceptsStromal-derived factor-1Oval cell proliferationLiver injuryLiver irradiationBile ductCell proliferationSDF-1 levelsArterial smooth muscleFactor 1Cell factorMarrow-derived progenitorsNormal mouse liverPlasma levelsBACKGROUND/Murine modelStem cell factorKupffer cellsSmooth muscleInjuryRegenerative responseOval cellsDihydrocollidineMouse liverMiceLiver progenitors
2000
Derivation of hepatocytes from bone marrow cells in mice after radiation‐induced myeloablation
Theise N, Badve S, Saxena R, Henegariu O, Sell S, Crawford J, Krause D. Derivation of hepatocytes from bone marrow cells in mice after radiation‐induced myeloablation. Hepatology 2000, 31: 235-240. PMID: 10613752, DOI: 10.1002/hep.510310135.Peer-Reviewed Original ResearchConceptsBone marrow cellsY chromosomeMarrow cellsFemale miceMessenger RNAWhole bone marrow transplantsAge-matched male donorsDerivation of hepatocytesSkeletal muscle regenerationSevere acute injuryAcute hepatic injuryBone marrow transplantationBone marrow transplantSimultaneous FISHFluorescence-activated cell sorterMale-derived cellsOval cell proliferationDays posttransplantationMonths posttransplantationHepatic injuryMarrow transplantationMarrow transplantAcute injuryMonth 2Hepatic engraftment