2011
Activation of autophagy in mesenchymal stem cells provides tumor stromal support
Sanchez CG, Penfornis P, Oskowitz AZ, Boonjindasup AG, Cai DZ, Dhule SS, Rowan BG, Kelekar A, Krause DS, Pochampally RR. Activation of autophagy in mesenchymal stem cells provides tumor stromal support. Carcinogenesis 2011, 32: 964-972. PMID: 21317300, PMCID: PMC3128555, DOI: 10.1093/carcin/bgr029.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAutophagyCell Line, TumorCell SurvivalCells, CulturedCulture Media, Serum-FreeFemaleHumansMesenchymal Stem CellsMiceMice, SCIDNeoplasmsStromal CellsConceptsSD-MSCsStromal cellsMesenchymal stem cellsMultipotential mesenchymal stem cellsMCF-7 tumor growthBreast cancer cell proliferationStem cellsVivo tumor xenograftsMCF-7 breast cancer cellsCancer cell proliferationSolid tumor survivalBreast cancer cellsBeclin-1 stainingActivation of autophagyAnti-apoptotic factorsTime-dependent increaseUpregulation of autophagySolid tumor microenvironmentBreast cancerImmunodeficient miceTumor xenograftsSolid tumorsTumor growthParacrine factorsSurvival mechanism
1998
Normal neutrophil differentiation and secondary granule gene expression in the EML and MPRO cell lines.
Lawson ND, Krause DS, Berliner N. Normal neutrophil differentiation and secondary granule gene expression in the EML and MPRO cell lines. Experimental Hematology 1998, 26: 1178-85. PMID: 9808058.Peer-Reviewed Original ResearchConceptsNeutrophil differentiationDominant-negative retinoic acid receptor alphaCell linesNormal neutrophil differentiationRetinoic acid receptor alphaCD11b/CD18Macrophage colony-stimulating factorDownregulation of CD34Granulocyte/macrophage colony-stimulating factorTrans retinoic acidAcid receptor alphaColony-stimulating factorNeutrophil gelatinaseGranulocytic differentiation programReceptor alphaSerum-free mediumAppropriate cytokinesMyeloid lineageRetinoic acidInduces expressionLeukemic myelopoiesisHL60MyelopoiesisNeutrophilic differentiationDifferentiation program