1998
Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors*
Mao J, Yuan H, Xie W, Simon M, Wu D. Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors*. Journal Of Biological Chemistry 1998, 273: 27118-27123. PMID: 9765229, DOI: 10.1074/jbc.273.42.27118.Peer-Reviewed Original ResearchMeSH Keywords15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid3T3 CellsAnimalsDNA-Binding ProteinsDrug SynergismEndothelinsGene Expression RegulationGTP-Binding ProteinsGTPase-Activating ProteinsLysophospholipidsMiceNuclear ProteinsProteinsReceptors, Cell SurfaceSerum Response FactorThrombinTranscription, GeneticConceptsThromboxane A2Lysophosphatidic acidType 1 muscarinic receptorG proteinsAlpha1-adrenergic receptorsInterleukin-8 receptorEndogenous G proteinsG protein-coupled receptorsProtein-coupled receptorsEndothelin receptorsMuscarinic receptorsDopamine receptorsSRF activationSerum response factorType 1Gene transcriptionReceptorsDifferent receptorsG protein subunitsSpecific involvementGalphaq/11Gq classCell linesNIH3T3 cellsThrombin
1996
Pertussis Toxin-sensitive Activation of Phospholipase C by the C5a and fMet-Leu-Phe Receptors*
Jiang H, Kuang Y, Wu Y, Smrcka A, Simon M, Wu D. Pertussis Toxin-sensitive Activation of Phospholipase C by the C5a and fMet-Leu-Phe Receptors*. Journal Of Biological Chemistry 1996, 271: 13430-13434. PMID: 8662841, DOI: 10.1074/jbc.271.23.13430.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigens, CDCell LineEnzyme ActivationGTP-Binding ProteinsMolecular Sequence DataPertussis ToxinReceptor, Anaphylatoxin C5aReceptors, ComplementReceptors, Formyl PeptideReceptors, ImmunologicReceptors, PeptideSignal TransductionTransfectionType C PhospholipasesVirulence Factors, BordetellaConceptsPLC-beta3PTX-sensitive G proteinsG proteinsFMet-LeuGbetagamma subunitsCOS-7 cellsPhospholipase CPLC-beta2Receptor-mediated PLC activationPTX-sensitive mannerFMLP-mediated activationPertussis toxinPhe receptorCell activationGi proteinsChemoattractant receptorsReceptorsPLC activationC5aBeta2Gq classActivationBeta3Betagamma subunitsSignal transduction pathwaysSelective G Protein Coupling by C-C Chemokine Receptors (∗)
Kuang Y, Wu Y, Jiang H, Wu D. Selective G Protein Coupling by C-C Chemokine Receptors (∗). Journal Of Biological Chemistry 1996, 271: 3975-3978. PMID: 8626727, DOI: 10.1074/jbc.271.8.3975.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvian ProteinsCell LineChemokine CCL2Chlorocebus aethiopsCloning, MolecularDNA PrimersDNA-Binding ProteinsGTP-Binding ProteinsHumansKineticsMonocytesPertussis ToxinPolymerase Chain ReactionReceptors, CCR2Receptors, ChemokineReceptors, CytokineRecombinant ProteinsTransfectionType C PhospholipasesVirulence Factors, BordetellaZinc FingersConceptsC chemokine receptor 1C chemokine receptorChemokine receptorsBroad spectrum anti-inflammatory drugsPertussis toxin-sensitive mannerChemokine receptor 1MCP-1 receptorAnti-inflammatory drugsG protein coupling specificityToxin-sensitive mannerGq classG protein couplingAccumulation of inositolPhospholipase CC chemokinesT cellsInflammatory reactionCotransfected COS-7 cellsGi proteinsReceptor 1Major mediatorC-terminal intracellular domainG beta gammaProtein couplingReceptors
1995
Different α1-Adrenergic Receptor Sequences Required for Activating Different Gα Subunits of Gq Class of G Proteins (∗)
Wu D, Jiang H, Simon M. Different α1-Adrenergic Receptor Sequences Required for Activating Different Gα Subunits of Gq Class of G Proteins (∗). Journal Of Biological Chemistry 1995, 270: 9828-9832. PMID: 7730363, DOI: 10.1074/jbc.270.17.9828.Peer-Reviewed Original ResearchConceptsG alpha 16G alpha 14Gq classAlpha 16Receptor sequencesDifferent G alpha subunitsAlpha subunitG proteinsG alpha q/11Different Gα subunitsG alpha subunitsAmino acid stretchAlpha q/11Alpha 14N-terminal segmentThird inner loopGα subunitsBBXXB motifRegulatory proteinsC-terminusN-terminusSpecific mutationsSubunitsProteinSpecific interactions
1994
Activation of phospholipase C beta 4 by heterotrimeric GTP-binding proteins.
Jiang H, Wu D, Simon M. Activation of phospholipase C beta 4 by heterotrimeric GTP-binding proteins. Journal Of Biological Chemistry 1994, 269: 7593-7596. PMID: 8125982, DOI: 10.1016/s0021-9258(17)37328-3.Peer-Reviewed Original ResearchConceptsPhospholipase C beta 4Beta 4PLC-beta 4C beta 4Gq classBeta 2 gamma 2Beta 1 gamma 2G alpha 15Alpha subunitG alpha 11G alpha qG alpha 16Gamma 2G beta gamma subunitsG alpha 14G beta 1 gamma 2Alpha 14Beta 1 gamma 1Beta gamma subunitsBeta 1 isoformAlpha 11Alpha qAlpha 15Heterotrimeric GTPGamma subunits