2001
Gα16 Couples Chemoattractant Receptors to NF-κB Activation
Yang M, Sang H, Rahman A, Wu D, Malik A, Ye R. Gα16 Couples Chemoattractant Receptors to NF-κB Activation. The Journal Of Immunology 2001, 166: 6885-6892. PMID: 11359849, DOI: 10.4049/jimmunol.166.11.6885.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAmino Acid SubstitutionCell NucleusEnzyme ActivationGenes, ReporterGlutamineGTP-Binding Protein alpha Subunits, Gq-G11HeLa CellsHeterotrimeric GTP-Binding ProteinsHumansIsoenzymesLeucineLuciferasesNF-kappa BPhospholipase C betaReceptors, ChemokineReceptors, Formyl PeptideReceptors, ImmunologicReceptors, PeptideSignal TransductionTrans-ActivatorsTransfectionType C PhospholipasesConceptsNF-kappaB activationFormyl peptide receptorChemoattractant receptorsPeptide receptorCXC chemokine receptor 2NF-kappaB.Chemokine receptor 2Regulatory protein alpha subunitNF-κB activationLuciferase activityProtein kinase CKappaB-luciferase activityPhosphorylation of IkappaBalphaPhospholipase C-beta activityC3a receptorReceptor 2Seven-membrane-spanning receptorsAgonist stimulationConventional PKC isoformsPharmacological inhibitorsLuciferase reporterReceptorsHemopoietic cellsProtein alpha subunitsCell model system
1999
Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids
Xie W, Samoriski G, McLaughlin J, Romoser V, Smrcka A, Hinkle P, Bidlack J, Gross R, Jiang H, Wu D. Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 10385-10390. PMID: 10468617, PMCID: PMC17897, DOI: 10.1073/pnas.96.18.10385.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCalcium ChannelsCell MembraneEnkephalin, Ala(2)-MePhe(4)-Gly(5)-EnkephalinsGanglia, SpinalGene Expression RegulationGene Expression Regulation, EnzymologicIsoenzymesMembrane PotentialsMiceMice, KnockoutMorphineNeurons, AfferentPainPhospholipase C betaReceptors, Opioid, deltaReceptors, Opioid, kappaReceptors, Opioid, muType C PhospholipasesConceptsBeta3-null miceDorsal root ganglion neuronsPLC-beta3Mu-opioid responseOpioid receptor numberSpecific mu agonistPrimary sensory neuronsPhospholipase CDelta-opioid receptorsWild-type neuronsBeta3-deficient miceProtein kinase CDAMGO responseMicro opioidsOpioid responseOpioid regulationMu agonistsOpioid sensitivityGanglion neuronsΜ-opioidOpioid receptorsReceptor numberSensory neuronsKinase CNumber of intracellular