2001
Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway
Mao J, Wang J, Liu B, Pan W, Farr G, Flynn C, Yuan H, Takada S, Kimelman D, Li L, Wu D. Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway. Molecular Cell 2001, 7: 801-809. PMID: 11336703, DOI: 10.1016/s1097-2765(01)00224-6.Peer-Reviewed Original Research3T3 CellsAmino Acid SequenceAnimalsAxin ProteinCalcium-Calmodulin-Dependent Protein KinasesCOS CellsGene ExpressionGlycogen Synthase Kinase 3LDL-Receptor Related ProteinsLow Density Lipoprotein Receptor-Related Protein-5MammalsMiceMolecular Sequence DataMutagenesisProtein BindingProtein Structure, TertiaryProteinsProto-Oncogene ProteinsReceptors, LDLRepressor ProteinsSignal TransductionWnt ProteinsZebrafish Proteins
2000
Structural basis of the recognition of the Dishevelled DEP domain in the Wnt signaling pathway
Wong H, Mao J, Nguyen J, Srinivas S, Zhang W, Liu B, Li L, Wu D, Zheng J. Structural basis of the recognition of the Dishevelled DEP domain in the Wnt signaling pathway. Nature Structural & Molecular Biology 2000, 7: 1178-1184. PMID: 11101902, PMCID: PMC4381838, DOI: 10.1038/82047.Peer-Reviewed Original Research3T3 CellsAdaptor Proteins, Signal TransducingAmino Acid SequenceAmino Acid SubstitutionAnimalsBinding SitesCell MembraneDishevelled ProteinsDNA-Binding ProteinsLymphoid Enhancer-Binding Factor 1Membrane ProteinsMiceModels, MolecularMolecular Sequence DataMutationNuclear Magnetic Resonance, BiomolecularPhosphoproteinsProtein BindingProtein FoldingProtein Structure, SecondaryProtein Structure, TertiaryProto-Oncogene ProteinsSequence AlignmentSignal TransductionStatic ElectricityStructure-Activity RelationshipSubstrate SpecificityTranscription FactorsTransfectionWnt ProteinsZebrafish Proteins
1999
Suppression of Glycogen Synthase Kinase Activity Is Not Sufficient for Leukemia Enhancer Factor-1 Activation*
Yuan H, Mao J, Li L, Wu D. Suppression of Glycogen Synthase Kinase Activity Is Not Sufficient for Leukemia Enhancer Factor-1 Activation*. Journal Of Biological Chemistry 1999, 274: 30419-30423. PMID: 10521419, DOI: 10.1074/jbc.274.43.30419.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAdaptor Proteins, Signal TransducingAnimalsAxin ProteinBeta CateninCalcium-Calmodulin-Dependent Protein KinasesCarrier ProteinsCytoskeletal ProteinsDNA-Binding ProteinsEnzyme ActivationGenes, ReporterGlycogen Synthase Kinase 3Glycogen Synthase KinasesLuciferasesLymphoid Enhancer-Binding Factor 1MiceNeoplasm ProteinsPhosphorylationProtein Serine-Threonine KinasesProtein-Tyrosine KinasesProteinsProto-Oncogene ProteinsProto-Oncogene Proteins c-aktRecombinant ProteinsRepressor ProteinsSignal TransductionTrans-ActivatorsTranscription FactorsTranscription, GeneticTransfectionWnt ProteinsWnt1 ProteinZebrafish ProteinsConceptsGlycogen synthase kinase-3LEF-1-dependent transcriptionKinase activityWnt proteinsWnt-1Glycogen synthase kinase activitySynthase kinase activityProtein kinase AktSynthase kinase-3Enhancer factor-1Kinase AktAxinKinase 3MAktPeptide substratesReduced associationAktPhe residueTyr-216Factor 1TranscriptionFRATProteinActivationAdditional mechanismAxin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt‐mediated regulation of LEF‐1
Li L, Yuan H, Weaver C, Mao J, Farr G, Sussman D, Jonkers J, Kimelman D, Wu D. Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt‐mediated regulation of LEF‐1. The EMBO Journal 1999, 18: 4233-4240. PMID: 10428961, PMCID: PMC1171499, DOI: 10.1093/emboj/18.15.4233.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAxin ProteinCalcium-Calmodulin-Dependent Protein KinasesDishevelled ProteinsDNA-Binding ProteinsGlycogen Synthase Kinase 3Glycogen Synthase KinasesLymphoid Enhancer-Binding Factor 1PhosphoproteinsProtein BindingProtein ConformationProteinsProto-Oncogene ProteinsRepressor ProteinsSignal TransductionTranscription FactorsWnt ProteinsWnt1 ProteinXenopusXenopus ProteinsZebrafish Proteins