1997
α-Latrotoxin Stimulates Exocytosis by the Interaction with a Neuronal G-Protein-Coupled Receptor
Krasnoperov V, Bittner M, Beavis R, Kuang Y, Salnikow K, Chepurny O, Little A, Plotnikov A, Wu D, Holz R, Petrenko A. α-Latrotoxin Stimulates Exocytosis by the Interaction with a Neuronal G-Protein-Coupled Receptor. Neuron 1997, 18: 925-937. PMID: 9208860, DOI: 10.1016/s0896-6273(00)80332-3.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBrain ChemistryCalciumCattleChromaffin GranulesCloning, MolecularCOS CellsDimerizationExocytosisGTP-Binding ProteinsMembrane ProteinsMolecular Sequence DataProtein PrecursorsQa-SNARE ProteinsRatsReceptors, Cell SurfaceReceptors, PeptideRecombinant ProteinsSensory Receptor CellsSequence AlignmentSequence Homology, Amino AcidSignal TransductionSpider VenomsTissue DistributionConceptsG protein-coupled receptorsAlpha-latrotoxin receptorNeuronal G protein-coupled receptorNovel orphan G-protein-coupled receptorI alphaCalcium-independent receptorSecretin receptor familyOrphan G protein-coupled receptorRegulation of neurosecretionEndogenous proteolytic cleavageMolecular cloningPrecursor polypeptideSerpentine receptorsCIRLFusion complexExtracellular bindingAlpha-LatrotoxinFunctional expressionReceptor familyProteolytic cleavagePresynaptic receptorsAffinity columnNeurotransmitter releaseStable complexesPresynaptic neurotoxins
1994
Activation of phospholipase C beta 4 by heterotrimeric GTP-binding proteins.
Jiang H, Wu D, Simon M. Activation of phospholipase C beta 4 by heterotrimeric GTP-binding proteins. Journal Of Biological Chemistry 1994, 269: 7593-7596. PMID: 8125982, DOI: 10.1016/s0021-9258(17)37328-3.Peer-Reviewed Original ResearchConceptsPhospholipase C beta 4Beta 4PLC-beta 4C beta 4Gq classBeta 2 gamma 2Beta 1 gamma 2G alpha 15Alpha subunitG alpha 11G alpha qG alpha 16Gamma 2G beta gamma subunitsG alpha 14G beta 1 gamma 2Alpha 14Beta 1 gamma 1Beta gamma subunitsBeta 1 isoformAlpha 11Alpha qAlpha 15Heterotrimeric GTPGamma subunits