A Novel Saliva and Serum miRNA Panel as a Potential Useful Index for Oral Cancer and the Association of miR-21 with Smoking History: a Pilot Study.
Vageli D, Doukas P, Shah R, Boyi T, Liu C, Judson B. A Novel Saliva and Serum miRNA Panel as a Potential Useful Index for Oral Cancer and the Association of miR-21 with Smoking History: a Pilot Study. Cancer Prevention Research 2023, 16: 653-659. PMID: 37683274, DOI: 10.1158/1940-6207.capr-23-0219.Peer-Reviewed Original ResearchConceptsOral squamous cell carcinomaSerum miR-21Oral cancerMiR-136MiR-21Smoking historyPilot studySerum miRNAsEarly-stage oral squamous cell carcinomaMiR-29bSquamous cell carcinomaEarly malignant lesionsEarly-stage tumorsSerum miRNA panelFurther validationUseful indexSmoking statusCell carcinomaHealthy controlsPoor survivalTobacco useHealthy volunteersLarge cohortMalignant lesionsSmokersExosomal MicroRNA-223, MicroRNA-146, and MicroRNA-21 Profiles and Biochemical Changes in Laryngeal Cancer
Genc S, Yagci T, Vageli D, Dundar R, Doukas P, Doukas S, Tolia M, Chatzakis N, Tsatsakis A, Taghizadehghalehjoughi A. Exosomal MicroRNA-223, MicroRNA-146, and MicroRNA-21 Profiles and Biochemical Changes in Laryngeal Cancer. ACS Pharmacology & Translational Science 2023, 6: 820-828. PMID: 37200807, PMCID: PMC10186621, DOI: 10.1021/acsptsci.3c00038.Peer-Reviewed Original ResearchC-reactive proteinExosomal miR-223MiR-223MiR-146MiR-21Serum C-reactive proteinVitamin B12Vitamin B12 levelsSerum vitamin B12Squamous cell carcinomaReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionSerum exosomal microRNAsMicroRNA-146B12 levelsLiquid chromatography-quadrupole timeLSCC patientsCell carcinomaPolymerase chain reactionLaryngeal cancerHealthy controlsEarly diagnosisAggressive cancerSerum exosomesMicroRNA-223