2023
Gastric cancer after Bariatric Bypass Surgery. Do they relate? (A Systematic Review)
Doukas S, Doukas P, Vageli D, Broder A. Gastric cancer after Bariatric Bypass Surgery. Do they relate? (A Systematic Review). Obesity Surgery 2023, 33: 1876-1888. PMID: 37041375, DOI: 10.1007/s11695-023-06567-6.Peer-Reviewed Original ResearchConceptsBariatric bypass surgeryBypass surgeryGastric cancerGastric cancer risk assessmentGastric bypass surgeryH. pylori infectionGastric cancer surveillanceCancer-promoting factorGastric cancer casesCancer risk assessmentBile refluxMorbid obesityTobacco smokingPylori infectionCancer surveillanceRisk factorsCancer casesFamily historyEffective treatmentSurgeryAdvanced stageSystematic reviewCancerFurther investigationObesity
2022
Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo.
Vageli DP, Doukas PG, Doukas SG, Tsatsakis A, Judson BL. Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo. Cancer Prevention Research 2022, 15: 297-308. PMID: 35502554, DOI: 10.1158/1940-6207.capr-21-0529.Peer-Reviewed Original ResearchConceptsHypopharyngeal squamous cell carcinomaTobacco smoke componentsSquamous cell carcinomaAerodigestive tract carcinogenesisBile refluxRisk factorsHypopharyngeal cancerCell carcinomaChronic exposureNFκB activationVivo modelUpper aerodigestive tract cancerNoxious combinationLarge-scale studiesIndependent risk factorAerodigestive tract cancerUpper aerodigestive tract carcinogenesisHigh-risk individualsVivo chronic exposurePresence of bileSilent progressionTract cancerTobacco smokingInvasive carcinomaPremalignant lesions