2023
A Novel Saliva and Serum miRNA Panel as a Potential Useful Index for Oral Cancer and the Association of miR-21 with Smoking History: a Pilot Study.
Vageli D, Doukas P, Shah R, Boyi T, Liu C, Judson B. A Novel Saliva and Serum miRNA Panel as a Potential Useful Index for Oral Cancer and the Association of miR-21 with Smoking History: a Pilot Study. Cancer Prevention Research 2023, 16: 653-659. PMID: 37683274, DOI: 10.1158/1940-6207.capr-23-0219.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorCarcinoma, Squamous CellHead and Neck NeoplasmsHumansMicroRNAsMouth NeoplasmsPilot ProjectsSalivaSmokingSquamous Cell Carcinoma of Head and NeckConceptsOral squamous cell carcinomaSerum miR-21Oral cancerMiR-136MiR-21Smoking historyPilot studySerum miRNAsEarly-stage oral squamous cell carcinomaMiR-29bSquamous cell carcinomaEarly malignant lesionsEarly-stage tumorsSerum miRNA panelFurther validationUseful indexSmoking statusCell carcinomaHealthy controlsPoor survivalTobacco useHealthy volunteersLarge cohortMalignant lesionsSmokers
2022
Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo.
Vageli DP, Doukas PG, Doukas SG, Tsatsakis A, Judson BL. Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo. Cancer Prevention Research 2022, 15: 297-308. PMID: 35502554, DOI: 10.1158/1940-6207.capr-21-0529.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBileBile RefluxCarcinogenesisDeoxycholic AcidHead and Neck NeoplasmsHypopharyngeal NeoplasmsMiceNF-kappa BNitrosaminesSmokeSquamous Cell Carcinoma of Head and NeckTobaccoTobacco Smoke PollutionConceptsHypopharyngeal squamous cell carcinomaTobacco smoke componentsSquamous cell carcinomaAerodigestive tract carcinogenesisBile refluxRisk factorsHypopharyngeal cancerCell carcinomaChronic exposureNFκB activationVivo modelUpper aerodigestive tract cancerNoxious combinationLarge-scale studiesIndependent risk factorAerodigestive tract cancerUpper aerodigestive tract carcinogenesisHigh-risk individualsVivo chronic exposurePresence of bileSilent progressionTract cancerTobacco smokingInvasive carcinomaPremalignant lesions