2009
Translocating cell‐impermeable molecules through the plasma membrane of cancer cells
THEVENIN D, An M, Andreev O, Reshetnyak Y, Engelman D. Translocating cell‐impermeable molecules through the plasma membrane of cancer cells. The FASEB Journal 2009, 23: 796.7-796.7. DOI: 10.1096/fasebj.23.1_supplement.796.7.Peer-Reviewed Original ResearchCell-impermeable moleculesCell-impermeable cargo moleculesDrug designLipid bilayersHost-guest modelMembrane-impermeable cargoNovel delivery systemPhysiological pHTraverse membranesModel cargoCancer cell membraneDelivery systemCargo moleculesMoleculesCargo propertiesBilayersPeptidesMembraneSingle amino acidPropertiesC-terminusAmino acidsPotential therapeutic agentTherapeutic agentsAcidity
2006
ph‐Triggered Transport of Molecules into Cells by Transmembrane Helix Insertion
Engelman D, Andreev O, Reshetnyak Y. ph‐Triggered Transport of Molecules into Cells by Transmembrane Helix Insertion. The FASEB Journal 2006, 20: a457-a457. DOI: 10.1096/fasebj.20.4.a457-b.Peer-Reviewed Original ResearchC-terminusTransmembrane helix insertionActin cytoskeletonHelix insertionPlasma membraneTransbilayer helicesTarget cellsCell contractilityBiophysical measurementsCancer cellsDisulfide linksCytoplasmCellsWater-soluble peptidesDiseased tissuesPeptidesMembraneAcidic pHCytoskeletonFluorescent dyeHelixPhalloidinAcidic environmentMoleculesInjection of molecules
1987
Transmembrane topography of the nicotinic acetylcholine receptor delta subunit.
McCrea P, Popot J, Engelman D. Transmembrane topography of the nicotinic acetylcholine receptor delta subunit. The EMBO Journal 1987, 6: 3619-3626. PMID: 3428268, PMCID: PMC553829, DOI: 10.1002/j.1460-2075.1987.tb02693.x.Peer-Reviewed Original ResearchConceptsDisulfide bridgesAcetylcholine receptor delta subunitIntermolecular disulfide bridgesTransmembrane topographyTransmembrane segmentsTransmembrane crossingReceptor delta subunitCellular locationC-terminusN-terminusDelta subunitNicotinic acetylcholine receptorsSubunitsElectric organVesiclesPermeability barrierTorpedo marmorataVesicle systemAcetylcholine receptorsDiphtheria toxinAqueous spaceDimers