2023
Tumor treatment by pHLIP-targeted antigen delivery
DuPont M, Visca H, Moshnikova A, Engelman D, Reshetnyak Y, Andreev O. Tumor treatment by pHLIP-targeted antigen delivery. Frontiers In Bioengineering And Biotechnology 2023, 10: 1082290. PMID: 36686229, PMCID: PMC9853002, DOI: 10.3389/fbioe.2022.1082290.Peer-Reviewed Original ResearchAnti-HA antibodiesAntigen deliveryHigh titersTumor cellsTriple-negative breast tumorsCancer cellsDifferent vaccination schemesNegative breast tumorsHA epitopeAntigen therapyImmunized miceImmune cellsNeo-antigensT cellsSignificant tumorsVaccination schemeViral infectionTherapeutic efficacyBreast tumorsHepatic clearanceImmune systemMelanoma tumorsTumorsPeptide epitopesAdjuvant
2022
Eradication of tumors and development of anti-cancer immunity using STINGa targeted by pHLIP
Moshnikova A, DuPont M, Visca H, Engelman D, Andreev O, Reshetnyak Y. Eradication of tumors and development of anti-cancer immunity using STINGa targeted by pHLIP. Frontiers In Oncology 2022, 12: 1023959. PMID: 36330464, PMCID: PMC9622777, DOI: 10.3389/fonc.2022.1023959.Peer-Reviewed Original ResearchTumor-associated macrophagesCancer-associated fibroblastsSTING agonistsT cellsTumor microenvironmentDendritic cellsCT26 tumorsM2-type tumor-associated macrophagesAnti-cancer immunityTumor-free miceEradication of tumorsActivation of cytokinesNovel STING agonistSuppressor cellsSingle doseImmune cellsIntratumoral hemorrhageTherapeutic effectTumor stromaImmune memoryNude miceAdditional injectionTumorsCancer cellsMiceTargeting bladder urothelial carcinoma with pHLIP-ICG and inhibition of urothelial cancer cell proliferation by pHLIP-amanitin
Moshnikova A, Golijanin B, Amin A, Doyle J, Kott O, Gershman B, DuPont M, Li Y, Lu X, Engelman D, Andreev O, Reshetnyak Y, Golijanin D. Targeting bladder urothelial carcinoma with pHLIP-ICG and inhibition of urothelial cancer cell proliferation by pHLIP-amanitin. Frontiers In Urology 2022, 2: 868919. PMID: 36439552, PMCID: PMC9691284, DOI: 10.3389/fruro.2022.868919.Peer-Reviewed Original ResearchWhite light cystoscopyCancer cell proliferationUrothelial cancer cellsMalignant lesionsUrothelial cancerBladder cancerCancer cellsSuperficial bladder cancerLaparoscopic radical cystectomyBladder urothelial carcinomaCell proliferationHr of treatmentRadical cystectomyIntravesical instillationBladder specimensUrothelial carcinomaUseful biomarkerNIRF imagingHuman bladderSitu casesDifferent subtypesHistopathological processingCystoscopyTumor cellsCancer
2006
ph‐Triggered Transport of Molecules into Cells by Transmembrane Helix Insertion
Engelman D, Andreev O, Reshetnyak Y. ph‐Triggered Transport of Molecules into Cells by Transmembrane Helix Insertion. The FASEB Journal 2006, 20: a457-a457. DOI: 10.1096/fasebj.20.4.a457-b.Peer-Reviewed Original ResearchC-terminusTransmembrane helix insertionActin cytoskeletonHelix insertionPlasma membraneTransbilayer helicesTarget cellsCell contractilityBiophysical measurementsCancer cellsDisulfide linksCytoplasmCellsWater-soluble peptidesDiseased tissuesPeptidesMembraneAcidic pHCytoskeletonFluorescent dyeHelixPhalloidinAcidic environmentMoleculesInjection of molecules