2000
HELICAL MEMBRANE PROTEIN FOLDING, STABILITY, AND EVOLUTION
Popot J, Engelman D. HELICAL MEMBRANE PROTEIN FOLDING, STABILITY, AND EVOLUTION. Annual Review Of Biochemistry 2000, 69: 881-922. PMID: 10966478, DOI: 10.1146/annurev.biochem.69.1.881.Peer-Reviewed Original Research
1995
Helix-helix interactions inside membranes
Engelman D, Adair B, Brunger A, Hunt J, Kahn T, Lemmon M, MacKenzie K, Treutlein H. Helix-helix interactions inside membranes. Molecular And Cell Biology Updates 1995, 297-310. DOI: 10.1007/978-3-0348-9057-1_21.Peer-Reviewed Original Research
1994
Specificity and promiscuity in membrane helix interactions
Lemmon M, Engelman D. Specificity and promiscuity in membrane helix interactions. FEBS Letters 1994, 346: 17-20. PMID: 8206151, DOI: 10.1016/0014-5793(94)00467-6.Peer-Reviewed Original ResearchSpecificity and promiscuity in membrane helix interactions
Lemmon M, Engelman D. Specificity and promiscuity in membrane helix interactions. Quarterly Reviews Of Biophysics 1994, 27: 157-218. PMID: 7984776, DOI: 10.1017/s0033583500004522.Peer-Reviewed Original ResearchConceptsIntegral membrane proteinsTransmembrane α-helicesMembrane proteinsΑ-helixMembrane protein foldingMembrane-spanning portionTransmembrane helix associationHelix-helix interactionsParticular helicesProtein foldingHelix associationHelix interactionsProsthetic groupLipid bilayersCharge-charge interactionsStereochemical fitFoldingProteinAccessible statesSpecificityOligomerizationInteractionPromiscuityHelixAssemblyA dimerization motif for transmembrane α–helices
Lemmon M, Treutlein H, Adams P, Brünger A, Engelman D. A dimerization motif for transmembrane α–helices. Nature Structural & Molecular Biology 1994, 1: 157-163. PMID: 7656033, DOI: 10.1038/nsb0394-157.Peer-Reviewed Original ResearchConceptsTransmembrane α-helicesHydrophobic transmembrane α-helicesSpecific helix-helix interactionsΑ-helixIntegral membrane proteinsHelix-helix interactionsHelix-helix interfaceDimerization motifSpecific dimerizationMembrane proteinsHelix associationFunctional analysisAmino acidsSuch motifsLipid bilayersMotifParticular motifsFoldingDimerizationSuch interactionsComplex membranesProteinOligomerizationVariety of systemsInteraction
1992
Helix-helix interactions inside lipid bilayers
Lemmon M, Engelman D. Helix-helix interactions inside lipid bilayers. Current Opinion In Structural Biology 1992, 2: 511-518. PMCID: PMC7133266, DOI: 10.1016/0959-440x(92)90080-q.Peer-Reviewed Original ResearchTransmembrane α-helicesHelix-helix interactionsΑ-helixSingle transmembrane α-helixMechanism of transmembraneIntegral membrane proteinsNumber of proteinsMembrane-bound receptorsTransmembrane helicesInterhelical salt bridgesMembrane proteinsSoluble proteinSuch oligomerizationEndoplasmic reticulumHydrophobic anchorSuch helicesProteinLipid bilayersSalt bridgePacking interactionsOligomerizationSpecific interactionsCrystallographic studiesHelixGolgiIntramembrane Helix-Helix Association in Oligomerization and Transmembrane Signaling
Bormann B, Engelman D. Intramembrane Helix-Helix Association in Oligomerization and Transmembrane Signaling. Annual Review Of Biophysics 1992, 21: 223-242. PMID: 1326354, DOI: 10.1146/annurev.bb.21.060192.001255.Peer-Reviewed Original ResearchConceptsProtein foldingTransmembrane regionReceptor proteinClose contact sitesSignal transductionQuaternary structureReceptor moleculesConformational changesHelical transmembrane regionsAllosteric conformational changeHelix-helix associationConformational change modelTertiary/quaternary structureTransmembrane helicesTransmembrane domainMechanism of insertionCytoplasmic domainTransmembrane signalingContact sitesPrimary structureSecondary structureProteinOligomerizationFoldingProteolytic fragments
1990
Membrane protein folding and oligomerization: the two-stage model.
Popot J, Engelman D. Membrane protein folding and oligomerization: the two-stage model. Biochemistry 1990, 29: 4031-7. PMID: 1694455, DOI: 10.1021/bi00469a001.Peer-Reviewed Original ResearchConceptsMembrane protein foldingIntegral membrane proteinsMembrane proteinsProtein foldingMembrane protein subunitsTransmembrane segmentsTransmembrane structureSequence dataProtein subunitsVariety of functionsAqueous channelsLipid bilayersFoldingProteinSubunitsOligomerizationAssemblyFragmentsBilayers