Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides
Reshetnyak Y, Andreev O, Engelman D. Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides. Frontiers In Pharmacology 2024, 15: 1355893. PMID: 38545547, PMCID: PMC10965573, DOI: 10.3389/fphar.2024.1355893.Peer-Reviewed Original ResearchTumor microenvironmentTherapeutic agents to solid tumorsTargeted intracellular deliverySolid tumorsImmune cellsPHLIP technologyTargeted delivery of imagingPre-clinicalDelivery of imagingTherapeutic payloadsTumorTargeted deliveryIntracellular deliveryTumor imagingSimultaneous targetingClinical applicationTherapeutic deliveryCell typesSurface of cellsPHLIP peptidePHLIPDeliveryTarget biomarkersCellsMagic bulletTargeted intracellular delivery of dimeric STINGa by two pHLIP peptides for treatment of solid tumors
Moshnikova A, DuPont M, Iraca M, Klumpp C, Visca H, Allababidi D, Pelzer P, Engelman D, Andreev O, Reshetnyak Y. Targeted intracellular delivery of dimeric STINGa by two pHLIP peptides for treatment of solid tumors. Frontiers In Pharmacology 2024, 15: 1346756. PMID: 38495104, PMCID: PMC10940318, DOI: 10.3389/fphar.2024.1346756.Peer-Reviewed Original ResearchTargeted intracellular deliveryIntracellular deliveryTreatment of solid tumorsAnti-cancer immunityPHLIP peptideBinding to plasma proteinsBlood half-lifeTumor eradicationSolid tumorsCytokine activityTumorTargeted deliveryDelivery approachesHalf-lifePlasma proteinsDMSAPHLIPDeliveryMembrane lipid bilayerPeptidepHLIP targeted intracellular delivery of calicheamicin
DuPont M, Klumpp C, Iraca M, Allababidi D, Visca H, Engelman D, Andreev O, Moshnikova A, Reshetnyak Y. pHLIP targeted intracellular delivery of calicheamicin. International Journal Of Pharmaceutics 2024, 654: 123954. PMID: 38428548, DOI: 10.1016/j.ijpharm.2024.123954.Peer-Reviewed Original ResearchM2 tumor-associated macrophagesTreatment of solid tumorsTumor-associated macrophagesTherapeutic agents to tumorsTumor-stroma interfaceAgents to tumorsInhibited tumor growthPolarized M2 macrophagesTreatment of tumorsAntibody-drug conjugatesTumor massLiquid tumorsSolid tumorsImmune cellsTumor growthM2 macrophagesTumorPH low insertion peptideBiodistribution studiesIntracellular deliveryIn vivoTumor coreCalicheamicinMacrophagesTreatment