2024
Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides
Reshetnyak Y, Andreev O, Engelman D. Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides. Frontiers In Pharmacology 2024, 15: 1355893. PMID: 38545547, PMCID: PMC10965573, DOI: 10.3389/fphar.2024.1355893.Peer-Reviewed Original ResearchTumor microenvironmentTherapeutic agents to solid tumorsTargeted intracellular deliverySolid tumorsImmune cellsPHLIP technologyTargeted delivery of imagingPre-clinicalDelivery of imagingTherapeutic payloadsTumorTargeted deliveryIntracellular deliveryTumor imagingSimultaneous targetingClinical applicationTherapeutic deliveryCell typesSurface of cellsPHLIP peptidePHLIPDeliveryTarget biomarkersCellsMagic bullet
2022
Eradication of tumors and development of anti-cancer immunity using STINGa targeted by pHLIP
Moshnikova A, DuPont M, Visca H, Engelman D, Andreev O, Reshetnyak Y. Eradication of tumors and development of anti-cancer immunity using STINGa targeted by pHLIP. Frontiers In Oncology 2022, 12: 1023959. PMID: 36330464, PMCID: PMC9622777, DOI: 10.3389/fonc.2022.1023959.Peer-Reviewed Original ResearchTumor-associated macrophagesCancer-associated fibroblastsSTING agonistsT cellsTumor microenvironmentDendritic cellsCT26 tumorsM2-type tumor-associated macrophagesAnti-cancer immunityTumor-free miceEradication of tumorsActivation of cytokinesNovel STING agonistSuppressor cellsSingle doseImmune cellsIntratumoral hemorrhageTherapeutic effectTumor stromaImmune memoryNude miceAdditional injectionTumorsCancer cellsMice