2024
pHLIP targeted intracellular delivery of calicheamicin
DuPont M, Klumpp C, Iraca M, Allababidi D, Visca H, Engelman D, Andreev O, Moshnikova A, Reshetnyak Y. pHLIP targeted intracellular delivery of calicheamicin. International Journal Of Pharmaceutics 2024, 654: 123954. PMID: 38428548, DOI: 10.1016/j.ijpharm.2024.123954.Peer-Reviewed Original ResearchM2 tumor-associated macrophagesTreatment of solid tumorsTumor-associated macrophagesTherapeutic agents to tumorsTumor-stroma interfaceAgents to tumorsInhibited tumor growthPolarized M2 macrophagesTreatment of tumorsAntibody-drug conjugatesTumor massLiquid tumorsSolid tumorsImmune cellsTumor growthM2 macrophagesTumorPH low insertion peptideBiodistribution studiesIntracellular deliveryIn vivoTumor coreCalicheamicinMacrophagesTreatment
2022
Eradication of tumors and development of anti-cancer immunity using STINGa targeted by pHLIP
Moshnikova A, DuPont M, Visca H, Engelman D, Andreev O, Reshetnyak Y. Eradication of tumors and development of anti-cancer immunity using STINGa targeted by pHLIP. Frontiers In Oncology 2022, 12: 1023959. PMID: 36330464, PMCID: PMC9622777, DOI: 10.3389/fonc.2022.1023959.Peer-Reviewed Original ResearchTumor-associated macrophagesCancer-associated fibroblastsSTING agonistsT cellsTumor microenvironmentDendritic cellsCT26 tumorsM2-type tumor-associated macrophagesAnti-cancer immunityTumor-free miceEradication of tumorsActivation of cytokinesNovel STING agonistSuppressor cellsSingle doseImmune cellsIntratumoral hemorrhageTherapeutic effectTumor stromaImmune memoryNude miceAdditional injectionTumorsCancer cellsMice