2022
Breast Cancer Screening: Is There Room for De-escalation?
Kim L, Lannin D. Breast Cancer Screening: Is There Room for De-escalation? Current Breast Cancer Reports 2022, 14: 153-161. PMID: 36404936, PMCID: PMC9640864, DOI: 10.1007/s12609-022-00465-z.Peer-Reviewed Original ResearchThe Effect of Black Cohosh on Ki67 expression and Tumor Volume: A Pilot Study of Ductal Carcinoma in Situ Patients
Trant A, Chagpar A, Wei W, Neumeister V, Rimm D, Stavris K, Lurie B, Frederick C, Andrejeva L, Raghu M, Killelea B, Horowitz N, Lannin D, Knill-Selby E, Sturrock T, Hofstatter E. The Effect of Black Cohosh on Ki67 expression and Tumor Volume: A Pilot Study of Ductal Carcinoma in Situ Patients. Integrative Cancer Therapies 2022, 21: 15347354221137290. PMID: 36444764, PMCID: PMC9716631, DOI: 10.1177/15347354221137290.Peer-Reviewed Original ResearchConceptsTumor volumeBlack cohoshSitu patientsDuctal carcinomaAnti-inflammatory effectsTumor cellular proliferationBreast cancer treatmentCellular proliferationWilcoxon signed-rank testDCIS patientsAdverse eventsEligible subjectsWindow trialsCore biopsyInvasive diseaseKi67 expressionSigned-rank testBreast cancerGrade 3Hormone changesPatientsQuantitative immunofluorescenceBC extractSignificant toxicityCancer treatment
2021
ASO Visual Abstract: Assessing Interobserver Variability of Cosmetic Outcome Assessment in Breast Cancer Patients Undergoing Breast Conservation Surgery
Chagpar A, Berger E, Alperovich M, Zanieski G, Avraham T, Lannin D. ASO Visual Abstract: Assessing Interobserver Variability of Cosmetic Outcome Assessment in Breast Cancer Patients Undergoing Breast Conservation Surgery. Annals Of Surgical Oncology 2021, 28: 632-632. DOI: 10.1245/s10434-021-10584-z.Peer-Reviewed Original Research
2017
Association of LN Evaluation with Survival in Women Aged 70 Years or Older With Clinically Node-Negative Hormone Receptor Positive Breast Cancer
Chagpar AB, Hatzis C, Pusztai L, DiGiovanna MP, Moran M, Mougalian S, Sanft T, Evans S, Hofstatter E, Wilson LD, Lannin DR. Association of LN Evaluation with Survival in Women Aged 70 Years or Older With Clinically Node-Negative Hormone Receptor Positive Breast Cancer. Annals Of Surgical Oncology 2017, 24: 3073-3081. PMID: 28766195, DOI: 10.1245/s10434-017-5936-x.Peer-Reviewed Original ResearchConceptsBreast cancer-specific survivalLN evaluationPositive breast cancerOverall survivalBreast cancerHormone receptor-positive breast cancerWomen Aged 70 YearsReceptor-positive breast cancerLymph node evaluationCancer-specific survivalLower hazard rateLN surgeryBetter OSPatient ageSEER databasePatient selectionTumor characteristicsSEER dataPatientsNode evaluationHormone receptorsCancerSurvivalTreatment variablesNCDBDuration of neoadjuvant endocrine therapy and breast cancer outcomes.
Mougalian S, Soulos P, Lannin D, Pusztai L, Gross C, Killelea B. Duration of neoadjuvant endocrine therapy and breast cancer outcomes. Journal Of Clinical Oncology 2017, 35: e12129-e12129. DOI: 10.1200/jco.2017.35.15_suppl.e12129.Peer-Reviewed Original ResearchNeoadjuvant endocrine therapyEndocrine therapyClinical stagePathologic stageNational Cancer Data BasePR-positive breast cancerHigher nodal stageNetwork cancer programsAdjuvant endocrine therapyMultiple comorbid conditionsBreast cancer outcomesPopulation of patientsType of surgeryPositive breast cancerSimilar response ratesNeoadjuvant chemotherapyUnderwent surgeryNodal stageComorbid conditionsCancer outcomesLarge tumorsCancer programsBreast cancerOlder womenPatientsIntraoperative Injection of Technetium-99m Sulfur Colloid for Sentinel Lymph Node Biopsy in Breast Cancer Patients: A Single Institution Experience
Berrocal J, Saperstein L, Grube B, Horowitz NR, Chagpar AB, Killelea BK, Lannin DR. Intraoperative Injection of Technetium-99m Sulfur Colloid for Sentinel Lymph Node Biopsy in Breast Cancer Patients: A Single Institution Experience. Surgery Research And Practice 2017, 2017: 5924802. PMID: 28492062, PMCID: PMC5406738, DOI: 10.1155/2017/5924802.Peer-Reviewed Original ResearchNonsentinel lymph nodesLymph nodesSentinel lymph nodesIntraoperative injectionSulfur colloidNode biopsySentinel lymphSentinel nodesAdditional positive nonsentinel lymph nodesPositive nonsentinel lymph nodesPositive sentinel lymph nodesSentinel lymph node biopsyLymph node biopsySentinel node biopsySingle institution experienceBreast cancer patientsLong-term resultsAxillary dissectionInstitution experienceMetastatic carcinomaCancer patientsBreast centerMedian numberPatientsBiopsy
2015
Review of trends in adjuvant chemotherapy regimens in breast cancer over 10 year period at Yale New Haven Hospital (YNHH).
Gnanajothy R, Chung G, DiGiovanna M, Abu-Khalaf M, Lannin D, Harris L. Review of trends in adjuvant chemotherapy regimens in breast cancer over 10 year period at Yale New Haven Hospital (YNHH). Journal Of Clinical Oncology 2015, 33: 144-144. DOI: 10.1200/jco.2015.33.28_suppl.144.Peer-Reviewed Original Research
2014
Does three-dimensional intraoperative specimen imaging reduce the need for re-excision in breast cancer patients?
Chagpar A, Butler M, Killelea B, Horowitz N, Stavris K, Lannin D. Does three-dimensional intraoperative specimen imaging reduce the need for re-excision in breast cancer patients? Journal Of Clinical Oncology 2014, 32: 107-107. DOI: 10.1200/jco.2014.32.30_suppl.107.Peer-Reviewed Original ResearchMargin statusIntraoperative imagingFinal margin statusMedian tumor sizeBreast cancer patientsRe-excision ratesIntraoperative specimen radiographyCohort of interestIntraoperative marginsResidual tumorPartial mastectomyPositive marginsProspective studyTumor sizeCancer patientsInvasive cancerFurther excisionPathology resultsIntraoperative resectionPatientsDefinitive specimenSpecimen radiographyIntraoperative specimenSurgeons
2012
Predictors of microinvasion and its prognostic role in ductal carcinoma in situ.
Sue G, Lannin D, Killelea B, Horowitz N, Chagpar A. Predictors of microinvasion and its prognostic role in ductal carcinoma in situ. Journal Of Clinical Oncology 2012, 30: 188-188. DOI: 10.1200/jco.2012.30.27_suppl.188.Peer-Reviewed Original ResearchPossible microinvasionPrognostic roleDuctal carcinomaActuarial overall survivalRetrospective cohort studyHigh-grade DCISRisk of recurrenceLikelihood of recurrenceSPSS software version 19DCIS sizeSolid histologyChart reviewFinal pathologyGrade DCISOverall survivalSoftware version 19Cohort studyConsecutive patientsIndependent predictorsMedian ageSurgical excisionBreast centerMicroinvasionDCISPatientsAccuracy of breast MRI in predicting pathologic tumor size.
Caprio K, Chagpar A, Hooley R, Tavassoli F, Honarpishe H, Lannin D, Killelea B, Horowitz N. Accuracy of breast MRI in predicting pathologic tumor size. Journal Of Clinical Oncology 2012, 30: 1109-1109. DOI: 10.1200/jco.2012.30.15_suppl.1109.Peer-Reviewed Original ResearchPathologic tumor sizeTumor sizeAccuracy of MRIMRI sizePathologic sizePathology sizeBreast cancerMRI lesion sizeSitu breast cancerPreoperative planning toolFinal pathologyNeoadjuvant chemotherapyPatient agePathologic findingsTumor histologyPreoperative MRILesion sizeLesionsBreast MRISpearman's rho coefficientPatientsMRICancerModest correlationSpearman coefficient
2011
P3-05-08: Hormone Receptor Heterogeneity in Ductal Intraepithelial Neoplasia (Ductal Carcinoma In Situ) of the Breast.
Sowden M, Flynn C, Bossuyt V, Lannin D, Chagpar A. P3-05-08: Hormone Receptor Heterogeneity in Ductal Intraepithelial Neoplasia (Ductal Carcinoma In Situ) of the Breast. Cancer Research 2011, 71: p3-05-08-p3-05-08. DOI: 10.1158/0008-5472.sabcs11-p3-05-08.Peer-Reviewed Original ResearchDuctal intraepithelial neoplasiaHormone receptor statusReceptor statusNuclear gradeIntraepithelial neoplasiaSame tumorHormonal therapyDifferent nuclear gradesHospital tumor registryMedian patient ageMajority of patientsLobular intraepithelial neoplasiaDin-2DIN 1Cohort of interestDIN patientsPR positivityPatient ageER statusPR statusTumor RegistrySingle pathologistInvasive tumorsSame patientPatientsCharacteristics of multifocal and multicentric breast cancers detetected by preoperative MRI.
Killelea B, Grube B, Philpotts L, Sowden M, Horowitz N, Lannin D. Characteristics of multifocal and multicentric breast cancers detetected by preoperative MRI. Journal Of Clinical Oncology 2011, 29: 67-67. DOI: 10.1200/jco.2011.29.27_suppl.67.Peer-Reviewed Original ResearchBreast cancer patientsSecond tumorPreoperative MRISecond malignanciesPR statusCancer patientsBreast cancerER/PR statusMulticentric breast cancerSuspicious MRI findingsNumber of patientsDiagnosis of cancerLobular histologyNodal statusContralateral breastMRI findingsNode positiveTumor characteristicsTumor sizeHER2 statusAdditional tumorsSecondary lesionsSecondary tumorsPatientsControl group
2004
Is breast-conserving therapy in the genetically predisposed breast cancer patient a reasonable and appropriate option?
Haffty B, Lannin D. Is breast-conserving therapy in the genetically predisposed breast cancer patient a reasonable and appropriate option? European Journal Of Cancer 2004, 40: 1105-1108. PMID: 15110872, DOI: 10.1016/j.ejca.2004.01.032.Peer-Reviewed Original Research
2001
Multicenter Trial of Sentinel Node Biopsy for Breast Cancer Using Both Technetium Sulfur Colloid and Isosulfan Blue Dye
Tafra L, Lannin D, Swanson M, Van Eyk J, Verbanac K, Chua A, Ng P, Edwards M, Halliday B, Henry C, Sommers L, Carman C, Molin M, Yurko J, Perry R, Williams A. Multicenter Trial of Sentinel Node Biopsy for Breast Cancer Using Both Technetium Sulfur Colloid and Isosulfan Blue Dye. Annals Of Surgery 2001, 233: 51-59. PMID: 11141225, PMCID: PMC1421166, DOI: 10.1097/00000658-200101000-00009.Peer-Reviewed Original ResearchConceptsSentinel node biopsyMulticenter trialTechnetium sulfur colloidNode biopsyIsosulfan blueFalse negative rateOlder patientsSulfur colloidBreast cancerComplete lymph node dissectionInexperienced surgeonsLymph node dissectionMetastatic axillary nodesIsosulfan blue dyeSingle-institution seriesSentinel node localizationBreast cancer metastasisAnalysis of tumorsFalse-negative resultsNode dissectionAxillary nodesIndependent predictorsSentinel nodesPoor success ratePatients
1998
Racial Differences in Breast Cancer in a Rural Population: Comparison of Cytologic Nuclear Grade, Other Prognostic Factors, and Outcomes for Tumors Diagnosed by Fine‐Needle Aspiration Biopsy
Thomas P, Raab S, Lannin D, Slagel D, Silverman J. Racial Differences in Breast Cancer in a Rural Population: Comparison of Cytologic Nuclear Grade, Other Prognostic Factors, and Outcomes for Tumors Diagnosed by Fine‐Needle Aspiration Biopsy. The Breast Journal 1998, 4: 104-111. DOI: 10.1046/j.1524-4741.1998.420104.x.Peer-Reviewed Original ResearchFine-needle aspiration biopsyAfrican American patientsPrognostic factorsUnfavorable prognostic factorBreast cancerAfrican American womenCaucasian patientsNuclear gradeAspiration biopsyCaucasian counterpartsFavorable prognostic factorBreast cancer experienceRacial differencesNeedle aspiration biopsyCytologic nuclear gradeTumor sizeHistologic gradeTumor featuresSurvival disadvantagePatientsTumor typesCancer experienceCancerSmall sample sizeCaucasians