2003
A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk.
Han J, Hankinson SE, De Vivo I, Spiegelman D, Tamimi RM, Mohrenweiser HW, Colditz GA, Hunter DJ. A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk. Cancer Research 2003, 63: 8536-41. PMID: 14679022.Peer-Reviewed Original ResearchConceptsBreast cancer riskBeta-carotene levelsCancer riskInverse associationHealth StudyXRCC1 geneNurses' Health StudyMultivariate odds ratiosCase-control studyPotential protective effectPresent study populationHaplotype-tagging single nucleotide polymorphismsXRCC1 haplotypesCigarette smokingProspective studyCaucasian womenEffect modificationOdds ratioBreast cancerProtective effectStudy populationOxidative DNA damageBreast carcinogenesisGene-environment interactionsPlasma carotenoids
2002
Effect of multivitamin and vitamin A supplements on weight gain during pregnancy among HIV-1-infected women 1 , 2 , 3
Villamor E, Msamanga G, Spiegelman D, Antelman G, Peterson KE, Hunter DJ, Fawzi WW. Effect of multivitamin and vitamin A supplements on weight gain during pregnancy among HIV-1-infected women 1 , 2 , 3. American Journal Of Clinical Nutrition 2002, 76: 1082-1090. PMID: 12399282, DOI: 10.1093/ajcn/76.5.1082.Peer-Reviewed Original ResearchConceptsEffects of multivitaminsThird trimesterWeight gainVitamin AMultivitamin supplementationSecond trimesterHIV-1-positive womenAdverse pregnancy outcomesPlacebo-controlled trialGestational weight gainHIV-positive womenEnd of pregnancyPregnancy outcomesOral supplementsAverage weight gainProtective effectTrimesterLower weight gainMultivitaminsPregnancyWomen 1HIVWomenDar es SalaamLower rates
2001
The effect of fruit and vegetable intake on risk for coronary heart disease.
Joshipura K, Hu F, Manson J, Stampfer M, Rimm E, Speizer F, Colditz G, Ascherio A, Rosner B, Spiegelman D, Willett W. The effect of fruit and vegetable intake on risk for coronary heart disease. Annals Of Internal Medicine 2001, 134: 1106-14. PMID: 11412050, DOI: 10.7326/0003-4819-134-12-200106190-00010.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHeart diseaseVegetable intakeGreen leafy vegetablesProtective effectHealth StudyVegetable consumptionFatal coronary heart diseaseStandard cardiovascular risk factorsVitamin CCardiovascular risk factorsNonfatal myocardial infarctionNurses' Health StudyProspective cohort studyFood frequency questionnaireIntake of fruitsRich fruitsMain outcome measuresApparent protective effectAssociation of fruitYears of ageConsumption of fruitsEffect of fruitConstituents of fruitsMen 40
2000
Oral contraceptives and the incidence of multiple sclerosis
Hernán M, Hohol MJ, Olek MJ, Spiegelman D, Ascherio A. Oral contraceptives and the incidence of multiple sclerosis. Neurology 2000, 55: 848-853. PMID: 10994007, DOI: 10.1212/wnl.55.6.848.Peer-Reviewed Original ResearchConceptsRisk of MSHealth Study IIOral contraceptive useOral contraceptivesContraceptive useProtective effectHealth StudyNurses' Health Study IIAge-adjusted relative riskOral contraceptive historiesNurses' Health StudyProgression of MSDiagnosis of MSDuration of useCohort studyMS incidenceMS riskHormonal contraceptionMultiple sclerosisContraceptive historyRelative riskClinical dataProbable casesU.S. womenPast users
1999
Fruit and Vegetable Intake in Relation to Risk of Ischemic Stroke
Joshipura KJ, Ascherio A, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Hennekens CH, Spiegelman D, Willett WC. Fruit and Vegetable Intake in Relation to Risk of Ischemic Stroke. JAMA 1999, 282: 1233-1239. PMID: 10517425, DOI: 10.1001/jama.282.13.1233.Peer-Reviewed Original ResearchConceptsIschemic strokeIschemic stroke riskVegetable intakeRelative riskStroke riskGreen leafy vegetablesCardiovascular diseaseHealth StudyLower ischemic stroke riskStandard cardiovascular risk factorsCardiovascular risk factorsNurses' Health StudyProspective cohort studyApparent protective effectDay of fruitsConsumption of fruitsCohort studyHighest quintileLowest quintileRisk factorsTotal strokeProtective effectMAIN OUTCOMELower riskHealth professionals
1998
Vitamin A supplementation and severity of pneumonia in children admitted to the hospital in Dar es Salaam, Tanzania 1 2 3
Fawzi WW, Mbise RL, Fataki MR, Herrera MG, Kawau F, Hertzmark E, Spiegelman D, Ndossi G. Vitamin A supplementation and severity of pneumonia in children admitted to the hospital in Dar es Salaam, Tanzania 1 2 3. American Journal Of Clinical Nutrition 1998, 68: 187-192. PMID: 9665113, DOI: 10.1093/ajcn/68.1.187.Peer-Reviewed Original ResearchConceptsVitamin APlacebo groupTanzanian childrenLarge dosesAcute lower respiratory tract infectionLower respiratory tract infectionsImportant public health problemPlacebo-controlled trialRespiratory tract infectionsDay of admissionSeverity of pneumoniaBreast-feeding statusCourse of pneumoniaSevere clinical conditionMean numberPublic health problemRapid respiratory rateHospital stayTract infectionsDietary vitaminClinical conditionsProtective effectRespiratory diseaseHealth problemsNutritional statusMenstrual Cycle Characteristics and History of Ovulatory Infertility in Relation to Breast Cancer Risk in a Large Cohort of US Women
Garland M, Hunter D, Colditz G, Manson J, Stampfer M, Spiegelman D, Speizer F, Willett W. Menstrual Cycle Characteristics and History of Ovulatory Infertility in Relation to Breast Cancer Risk in a Large Cohort of US Women. American Journal Of Epidemiology 1998, 147: 636-643. PMID: 9554602, DOI: 10.1093/oxfordjournals.aje.a009504.Peer-Reviewed Original ResearchConceptsMultivariate relative riskHealth Study IIMenstrual cycle characteristicsBreast cancer riskRelative riskOvulatory infertilityBreast cancerCancer riskLonger menstrual cycle lengthNurses' Health Study IICycle lengthUsual cycle lengthProspective cohort studyMenstrual cycle lengthOvulatory menstrual cyclesCohort studyBaseline questionnaireMenstrual cycleLarge cohortProtective effectUS womenAge 18Study IIInfertilityCycle characteristics
1992
Dietary Fat and Fiber in Relation to Risk of Breast Cancer: An 8-Year Follow-up
Willett W, Hunter D, Stampfer M, Colditz G, Manson J, Spiegelman D, Rosner B, Hennekens C, Speizer F. Dietary Fat and Fiber in Relation to Risk of Breast Cancer: An 8-Year Follow-up. JAMA 1992, 268: 2037-2044. DOI: 10.1001/jama.1992.03490150089030.Peer-Reviewed Original ResearchTotal fat intakeBreast cancer incidenceFat intakeBreast cancerPostmenopausal womenCancer incidenceProtective effectHealth StudySelf-administered food frequency questionnaireEnergy intakePositive associationDietary fat increasesNurses' Health StudyProspective cohort studyFood frequency questionnaireTotal energy intakeMiddle-aged womenYears of ageDietary questionnaireCohort studyFrequency questionnaireIncident casesRisk factorsDietary fatCorresponding RRsDietary fat and fiber in relation to risk of breast cancer. An 8-year follow-up.
Willett WC, Hunter DJ, Stampfer MJ, Colditz G, Manson JE, Spiegelman D, Rosner B, Hennekens CH, Speizer FE. Dietary fat and fiber in relation to risk of breast cancer. An 8-year follow-up. JAMA 1992, 268: 2037-44. PMID: 1328696, DOI: 10.1001/jama.268.15.2037.Peer-Reviewed Original ResearchConceptsTotal fat intakeBreast cancer incidenceFat intakeBreast cancerPostmenopausal womenCancer incidenceProtective effectHealth StudySelf-administered food frequency questionnaireEnergy intakePositive associationDietary fat increasesNurses' Health StudyProspective cohort studyFood frequency questionnaireTotal energy intakeMiddle-aged womenYears of ageDietary questionnaireCohort studyFrequency questionnaireIncident casesRisk factorsDietary fatCorresponding RRs