2023
Trusted residents and housing assistance to decrease violence exposure in New Haven (TRUE HAVEN): a strengths-based and community-driven stepped-wedge intervention to reduce gun violence
Tong G, Spell V, Horton N, Thornhill T, Keene D, Montgomery C, Spiegelman D, Wang E, Roy B. Trusted residents and housing assistance to decrease violence exposure in New Haven (TRUE HAVEN): a strengths-based and community-driven stepped-wedge intervention to reduce gun violence. BMC Public Health 2023, 23: 1545. PMID: 37580653, PMCID: PMC10426138, DOI: 10.1186/s12889-023-15997-x.Peer-Reviewed Original ResearchMeSH KeywordsExposure to ViolenceGun ViolenceHumansMental Health ServicesProspective StudiesPublic HousingConceptsGun violenceHousing assistanceStructural racismHousing stabilityViolence exposureMulti-level interventionsCommunity gun violenceMulti-stakeholder coalitionsRental assistance programsCommunity-based organizationsHousing supportPolicy changesFinancial educationStable housingBeing of individualsViolenceTarget neighborhoodsCommunity membersNew HavenNeighborhood ratesAssistance programsOrganization leadersRacismHavenNeighborhood
2022
Iron supplementation and paediatric HIV disease progression: a cohort study among children receiving routine HIV care in Dar es Salaam, Tanzania
Andersen CT, Duggan CP, Manji K, Seage GR, Spiegelman D, Perumal N, Ulenga N, Fawzi WW. Iron supplementation and paediatric HIV disease progression: a cohort study among children receiving routine HIV care in Dar es Salaam, Tanzania. International Journal Of Epidemiology 2022, 51: 1533-1543. PMID: 35167662, PMCID: PMC9557856, DOI: 10.1093/ije/dyac017.Peer-Reviewed Original ResearchMeSH KeywordsAnemiaChildCohort StudiesDietary SupplementsDisease ProgressionHIV InfectionsHumansIronProspective StudiesTanzaniaConceptsDisease stage progressionIron supplementationStage progressionCohort studyDisease progressionRoutine HIV careHIV disease progressionProspective cohort studyManagement of anemiaRisk of anemiaHigher hazard rateProportional hazards modelIron supplement useDar es SalaamHaematological outcomesAntiretroviral therapyHIV careClinic visitsSupportive careAntiretroviral treatmentClinical outcomesClinical visitsAnemia statusSupplement useVital status
2021
Lessons Learned From COVID-19 Contact Tracing During a Public Health Emergency: A Prospective Implementation Study
Shelby T, Schenck C, Weeks B, Goodwin J, Hennein R, Zhou X, Spiegelman D, Grau LE, Niccolai L, Bond M, Davis JL. Lessons Learned From COVID-19 Contact Tracing During a Public Health Emergency: A Prospective Implementation Study. Frontiers In Public Health 2021, 9: 721952. PMID: 34490198, PMCID: PMC8417826, DOI: 10.3389/fpubh.2021.721952.Peer-Reviewed Original ResearchConceptsProspective implementation studyOutreach callsContact tracingAge-related disparitiesPublic health nursesRE-AIM implementation frameworkMultivariable regression modelsTimeliness of caseImplementation studyPublic health responsePublic health emergencyMedian timeHealth nursesAfrican American casesHealth responseInfectious diseasesFuture epidemicsDays of exposureHealth emergencyCOVID-19System-level predictorsRegression modelsCOVID-19 Contact TracingDaysPredictors
2020
Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study
McGee EE, Kim CH, Wang M, Spiegelman D, Stover DG, Heng YJ, Collins LC, Baker GM, Farvid MS, Schedin P, Jindal S, Tamimi RM, Eliassen AH. Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study. Breast Cancer Research 2020, 22: 78. PMID: 32698885, PMCID: PMC7374956, DOI: 10.1186/s13058-020-01316-4.Peer-Reviewed Original ResearchConceptsBreast cancer riskImmuno-inflammatory markersErythrocyte membrane fatty acidsCase-control studyTumor tissue expressionFatty acid synthaseCancer riskTrans fatty acidsExpression subtypesOdds ratioSpecific fatty acidsLogistic regressionHealth Study IITumor tissue blocksMembrane fatty acidsFatty acidsUnconditional logistic regressionConfidence intervalsTissue expressionT cell functionPolytomous logistic regressionAcid synthaseTumor CD4Potential confoundersTumor expression
2015
Sugar-sweetened beverage consumption and age at menarche in a prospective study of US girls
Carwile JL, Willett WC, Spiegelman D, Hertzmark E, Rich-Edwards J, Frazier AL, Michels KB. Sugar-sweetened beverage consumption and age at menarche in a prospective study of US girls. Human Reproduction 2015, 30: 675-683. PMID: 25628346, PMCID: PMC4325672, DOI: 10.1093/humrep/deu349.Peer-Reviewed Original ResearchConceptsFrequent SSB consumptionSugar-sweetened beverage consumptionServings of SSBsSSB consumptionEarly menarcheNational InstituteYouth/Adolescent Food Frequency QuestionnaireNurses' Health Study II participantsBeverage consumptionAdolescent Food Frequency QuestionnaireCox proportional hazards regressionBreast Cancer Research FoundationFood frequency questionnaireProspective cohort studyProportional hazards regressionFruit juice consumptionPARTICIPANTS/MATERIALSSugar-sweetened sodaAmerican Cancer SocietyROLE OF CHANCEPublic health effortsCancer Research FoundationNational Cancer InstituteToday StudyUS girls
2013
Clinical malaria diagnosis in pregnancy in relation to early perinatal mother‐to‐child transmission of HIV: a prospective cohort study
Ezeamama A, Duggan C, Manji K, Spiegelman D, Hertzmark E, Bosch R, Kupka R, Okuma J, Kisenge R, Aboud S, Fawzi W. Clinical malaria diagnosis in pregnancy in relation to early perinatal mother‐to‐child transmission of HIV: a prospective cohort study. HIV Medicine 2013, 15: 276-285. PMID: 24215465, PMCID: PMC4299572, DOI: 10.1111/hiv.12111.Peer-Reviewed Original ResearchConceptsPregnant HIV-positive womenHIV-positive womenRelative riskFever symptomsHIV MTCTHIV infectionPolymerase chain reactionHIV-positive pregnant womenMultivariable logistic regression modelCent of HIVChild's HIV statusHIV MTCT riskInfants of womenPerinatal HIV infectionChild HIV infectionLaboratory-confirmed diagnosisConfidence intervalsPrenatal health careWeeks of lifeLogistic regression modelsHIV motherMaternal malariaMTCT programmeMTCT riskChild transmissionDeterminants of anemia in postpartum HIV-negative women in Dar es Salaam, Tanzania
Petraro P, Duggan C, Urassa W, Msamanga G, Makubi A, Spiegelman D, Fawzi WW. Determinants of anemia in postpartum HIV-negative women in Dar es Salaam, Tanzania. European Journal Of Clinical Nutrition 2013, 67: 708-717. PMID: 23612515, PMCID: PMC3775569, DOI: 10.1038/ejcn.2013.71.Peer-Reviewed Original ResearchMeSH KeywordsAnemia, Iron-DeficiencyCD4 Lymphocyte CountDietDietary SupplementsErythrocyte IndicesFemaleFolic AcidHemoglobinsHIV InfectionsHumansIron, DietaryMaternal Nutritional Physiological PhenomenaMultivariate AnalysisPostpartum PeriodPregnancyProportional Hazards ModelsProspective StudiesRisk FactorsSocioeconomic FactorsTanzaniaConceptsIron/folate supplementationIron deficiency anemiaDeterminants of anemiaDeficiency anemiaFolate supplementationDelivery complicationsPregnant womenRisk factorsMultivariate Cox proportional hazards modelNon-anemic pregnant womenCox proportional hazards modelCD4 cell countHIV-negative womenModifiable risk factorsProspective cohort studyMaternal nutritional statusWeeks of gestationManagement of infectionsProportional hazards modelDar es SalaamSub-Saharan African womenBaseline anemiaIncident anemiaAnemic womenPostpartum anemia
2011
Predictors of change in nutritional and hemoglobin status among adults treated for tuberculosis in Tanzania
Kawai K, Villamor E, Mugusi FM, Saathoff E, Urassa W, Bosch RJ, Spiegelman D, Fawzi WW. Predictors of change in nutritional and hemoglobin status among adults treated for tuberculosis in Tanzania. The International Journal Of Tuberculosis And Lung Disease 2011, 15: 1380-1389. PMID: 22283899, PMCID: PMC3404808, DOI: 10.5588/ijtld.10.0784.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemiaAntitubercular AgentsBiomarkersBody Mass IndexCoinfectionFemaleHealth Status IndicatorsHemoglobinsHIV InfectionsHumansLinear ModelsMaleMalnutritionMultivariate AnalysisNutritional StatusNutritional SupportProspective StudiesTanzaniaTime FactorsTreatment OutcomeTuberculosis, PulmonaryYoung AdultConceptsLow CD4 cell countsHuman immunodeficiency virusBody mass indexCD4 cell countHIV-positive patientsTB treatmentCell countPredictors of changeTB patientsHemoglobin statusHIV-negative TB patientsHIV-positive TB patientsOlder ageHIV-negative adultsHIV-negative patientsPrevious TB infectionHIV-negative participantsAdequate nutritional supportHigh viral loadProfound malnutritionTB infectionPulmonary tuberculosisNutritional recoveryNutritional supportHemoglobin levelsFatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study
Wu J, Lemaitre RN, Imamura F, King IB, Song X, Spiegelman D, Siscovick DS, Mozaffarian D. Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study. American Journal Of Clinical Nutrition 2011, 94: 431-438. PMID: 21697077, PMCID: PMC3142722, DOI: 10.3945/ajcn.111.012054.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseNonfatal myocardial infarctionSudden cardiac arrestFatal coronary heart diseaseTotal coronary heart diseaseIncident coronary heart diseaseDe novo lipogenesisHigh riskCHD eventsHeart diseaseMultivariable-adjusted Cox proportional hazardsCommunity-based prospective studySecondary analysisCardiovascular disease risk factorsCardiovascular Health StudyDisease risk factorsFatty acidsCox proportional hazardsDe novo lipogenesis pathwayCHD deathCHD outcomesProspective studyCardiac arrestMyocardial infarctionMedical records
2009
Evaluation of a novel food composition database that includes glutamine and other amino acids derived from gene sequencing data
Lenders CM, Liu S, Wilmore DW, Sampson L, Dougherty LW, Spiegelman D, Willett WC. Evaluation of a novel food composition database that includes glutamine and other amino acids derived from gene sequencing data. European Journal Of Clinical Nutrition 2009, 63: 1433-1439. PMID: 19756030, PMCID: PMC3249386, DOI: 10.1038/ejcn.2009.110.Peer-Reviewed Original ResearchConceptsFood frequency questionnaireGlutamine intakeItem food frequency questionnaireEnergy-adjusted intakesContent of glutamineGene sequencing methodsMajor food proteinsGlutamine contentFrequency questionnaireDietary intakeHealth StudyAbsolute intakeNHS participantsFood composition databasesIntakeVs 4.4Person coefficientPearson correlation coefficientTotal proteinAmino acidsComposition databaseCorrelation coefficientFood proteinsSequencing methodsGlutamine consumptionThe relationship between handedness and risk of multiple sclerosis
Gardener H, Munger K, Chitnis T, Spiegelman D, Ascherio A. The relationship between handedness and risk of multiple sclerosis. Multiple Sclerosis Journal 2009, 15: 587-592. PMID: 19389750, PMCID: PMC2771381, DOI: 10.1177/1352458509102622.Peer-Reviewed Original ResearchConceptsMultiple sclerosisHealth StudyHand preferenceOngoing prospective cohort studyUtero hormone exposureNurses' Health StudyProspective cohort studyMultiple sclerosis riskSex steroid hormonesLeft-handed womenLeft-handed individualsCohort studyAutoimmune disordersIncident casesUtero exposureUnknown etiologyPrenatal exposureSex hormonesImmune disordersStudy populationHormone exposureSclerosisFemale nursesSteroid hormonesRisk
2007
Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials 1
Bischoff-Ferrari HA, Dawson-Hughes B, Baron JA, Burckhardt P, Li R, Spiegelman D, Specker B, Orav JE, Wong JB, Staehelin HB, O’Reilly E, Kiel DP, Willett WC. Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials 1. American Journal Of Clinical Nutrition 2007, 86: 1780-1790. PMID: 18065599, DOI: 10.1093/ajcn/86.5.1780.Peer-Reviewed Original ResearchConceptsHip fracture riskProspective cohort studyTotal calcium intakeCalcium intakeFracture riskNonvertebral fracturesCohort studyClinical trialsHip fractureCalcium supplementationCa/dPooled RRRandomized trialsSmall trialsIntakeTrialsTrial 1PlaceboWomenRiskMenSupplementationNeutral effectFracturesRR
2005
Predictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children
Jacobson DL, Spiegelman D, Duggan C, Weinberg GA, Bechard L, Furuta L, Nicchitta J, Gorbach SL, Miller TL. Predictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children. Journal Of Pediatric Gastroenterology And Nutrition 2005, 41: 339-346. PMID: 16131991, DOI: 10.1097/01.mpg.0000174468.75219.30.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAntiretroviral Therapy, Highly ActiveBlack or African AmericanBody CompositionBody HeightBody Mass IndexBody WeightBone DensityCase-Control StudiesChildChild DevelopmentCross-Sectional StudiesFemaleHispanic or LatinoHIV InfectionsHIV-1HumansLongitudinal StudiesMalePredictive Value of TestsProspective StudiesSeverity of Illness IndexVitaminsWhite PeopleConceptsBMD Z-scoresBone mineral densityLower BMD Z-scoresMineral densityZ-scorePopulation normsMultivitamin useDietary intakePredictors of BMDTotal body bone mineral densityLower weight z-scoreBody bone mineral densityLow bone mineral densitySibling controlsBetter bone mineral densityDual-energy X-ray absorptiometry (DXA) examinationDual-energy X-ray absorptiometryLower height Z-scoresHuman immunodeficiency virus-1Energy X-ray absorptiometryAdvanced HIV stageAge-adjusted percentileIndependent risk factorGender-adjusted z-scoresWeight z-scoreHIV-1 Disease Progression and Fertility in Dar es Salaam, Tanzania
Sedgh G, Larsen U, Spiegelman D, Msamanga G, Fawzi WW. HIV-1 Disease Progression and Fertility in Dar es Salaam, Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 39: 439-445. PMID: 16010167, DOI: 10.1097/01.qai.0000148529.58963.83.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCohort StudiesDisease ProgressionFemaleFertilityHIV InfectionsHumansParturitionPregnancyProspective StudiesTanzaniaConceptsHIV-1 disease progressionPregnancy rate ratioPregnancy incidenceDisease progressionRate ratioStage IHIV-1-infected womenHIV-1-positive womenCox proportional hazards modelClinical stage IIHIV-1 diseaseProspective cohort studyLive birth rateProportional hazards modelDar es SalaamLive birth incidenceCohort studyMenstrual dysfunctionIndependent predictorsRecent pregnancyHIV statusClinical progressionPregnancy rateOlder womenHazards modelSelenium levels in relation to morbidity and mortality among children born to HIV-infected mothers
Kupka R, Msamanga GI, Spiegelman D, Rifai N, Hunter DJ, Fawzi WW. Selenium levels in relation to morbidity and mortality among children born to HIV-infected mothers. European Journal Of Clinical Nutrition 2005, 59: 1250-1258. PMID: 16015252, DOI: 10.1038/sj.ejcn.1602236.Peer-Reviewed Original ResearchConceptsPlasma selenium levelsMorbidity informationSelenium levelsChild mortalityMaternal vitamin supplementsMonthly clinic visitsProspective cohort studyTertiary care hospitalMuhimbili National HospitalRisk of diarrheaChild health outcomesMonths of ageSelenium statusCause mortalityClinic visitsCohort studyRespiratory outcomesMedian ageStudy clinicNational HospitalVitamin supplementsHealth outcomesStudy childrenFogarty International CenterStudy participantsCorrelated errors in biased surrogates: study designs and methods for measurement error correction
Spiegelman D, Zhao B, Kim J. Correlated errors in biased surrogates: study designs and methods for measurement error correction. Statistics In Medicine 2005, 24: 1657-1682. PMID: 15736283, DOI: 10.1002/sim.2055.Peer-Reviewed Original ResearchInfluence of Body Size and Body Fat Distribution on Risk of Uterine Leiomyomata in U.S. Black Women
Wise LA, Palmer JR, Spiegelman D, Harlow BL, Stewart EA, Adams-Campbell LL, Rosenberg L. Influence of Body Size and Body Fat Distribution on Risk of Uterine Leiomyomata in U.S. Black Women. Epidemiology 2005, 16: 346-354. PMID: 15824551, PMCID: PMC1847589, DOI: 10.1097/01.ede.0000158742.11877.99.Peer-Reviewed Original ResearchConceptsBody mass indexIncidence rate ratiosBlack Women's Health StudyWomen's Health StudyParous womenUterine leiomyomataHealth StudyWeight gainMultivariate incidence rate ratiosSelf-reported uterine leiomyomataU.S. prospective cohort studiesBlack womenProspective cohort studyBody fat distributionConfidence intervalsU.S. Black womenPremenopausal womenCohort studyPrior diagnosisHip ratioMass indexHip circumferenceFat distributionHealth QuestionnaireLarge cohortDietary flavonols and flavonol‐rich foods intake and the risk of breast cancer
Adebamowo CA, Cho E, Sampson L, Katan MB, Spiegelman D, Willett WC, Holmes MD. Dietary flavonols and flavonol‐rich foods intake and the risk of breast cancer. International Journal Of Cancer 2005, 114: 628-633. PMID: 15609322, DOI: 10.1002/ijc.20741.Peer-Reviewed Original ResearchConceptsMultivariate relative riskBreast cancer riskCumulative average intakeFlavonol-rich foodsIntake of beansRelative riskBreast cancerCancer riskFlavonol intakeLowest quintileInverse associationDietary flavonolsAverage intakeNurses' Health Study IIIntake of flavonolsHealth Study IIFood frequency questionnaireInvasive breast cancerSignificant inverse associationFrequency questionnaireEpidemiological studiesAnimal studiesDietary dataOverall associationFurther evaluationPlasma Carotenoids, Retinol, and Tocopherols and Risk of Breast Cancer
Tamimi RM, Hankinson SE, Campos H, Spiegelman D, Zhang S, Colditz GA, Willett WC, Hunter DJ. Plasma Carotenoids, Retinol, and Tocopherols and Risk of Breast Cancer. American Journal Of Epidemiology 2005, 161: 153-160. PMID: 15632265, DOI: 10.1093/aje/kwi030.Peer-Reviewed Original ResearchConceptsLutein/zeaxanthinBreast cancerHealth StudyPlasma carotenoidsNurses' Health StudyBreast cancer riskCase-control studyBreast cancer etiologyNodal metastasisHighest quintileInvasive cancerLowest quintileBlood drawInverse associationCancer riskAlpha-tocopherolCancerCancer etiologyGamma-tocopherolWomenRetinolQuintileRiskRole of carotenoidsAssociationAdult Recall of Adolescent Diet: Reproducibility and Comparison with Maternal Reporting
Maruti SS, Feskanich D, Colditz GA, Frazier AL, Sampson LA, Michels KB, Hunter DJ, Spiegelman D, Willett WC. Adult Recall of Adolescent Diet: Reproducibility and Comparison with Maternal Reporting. American Journal Of Epidemiology 2005, 161: 89-97. PMID: 15615919, PMCID: PMC2293280, DOI: 10.1093/aje/kwi019.Peer-Reviewed Original ResearchConceptsHealth Study II cohortFood frequency questionnaireAdolescent dietFrequency questionnaireNurses' Health Study II cohortSpearman rank correlationLong latency periodAssessment of validityMaternal reportingProspective dataDietary factorsNHSII participantsCancer occurrenceFood intakePearson correlationUS womenRetrospective collectionLatency periodNutrient intakeRank correlationDietFurther studiesMean Pearson correlationIntakeWomen