2005
Insulin Resistance in HIV-Infected Men and Women in the Nutrition for Healthy Living Cohort
Jones CY, Wilson IB, Greenberg AS, Shevitz A, Knox TA, Gorbach SL, Spiegelman D, Jacobson DL, Wanke C. Insulin Resistance in HIV-Infected Men and Women in the Nutrition for Healthy Living Cohort. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 40: 202-211. PMID: 16186739, DOI: 10.1097/01.qai.0000165910.89462.2f.Peer-Reviewed Original ResearchConceptsQuantitative insulin sensitivity check indexWorse insulin resistancePrevalence of IRInsulin resistanceNHANES IIIHigher high-density lipoproteinInsulin sensitivity check indexNutrition Examination Survey IIIHealthy Living cohortHealthy Living StudyHIV-Infected MenMore insulin resistanceActive antiretroviral therapyCD4 cell countCross-sectional study designInjection drug useLess insulin resistanceExamination Survey IIINHANES III participantsGreater waist circumferenceHigh-density lipoproteinLow-density lipoproteinProtease inhibitorsLiving cohortPI-HAARTPredictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children
Jacobson DL, Spiegelman D, Duggan C, Weinberg GA, Bechard L, Furuta L, Nicchitta J, Gorbach SL, Miller TL. Predictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children. Journal Of Pediatric Gastroenterology And Nutrition 2005, 41: 339-346. PMID: 16131991, DOI: 10.1097/01.mpg.0000174468.75219.30.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAntiretroviral Therapy, Highly ActiveBlack or African AmericanBody CompositionBody HeightBody Mass IndexBody WeightBone DensityCase-Control StudiesChildChild DevelopmentCross-Sectional StudiesFemaleHispanic or LatinoHIV InfectionsHIV-1HumansLongitudinal StudiesMalePredictive Value of TestsProspective StudiesSeverity of Illness IndexVitaminsWhite PeopleConceptsBMD Z-scoresBone mineral densityLower BMD Z-scoresMineral densityZ-scorePopulation normsMultivitamin useDietary intakePredictors of BMDTotal body bone mineral densityLower weight z-scoreBody bone mineral densityLow bone mineral densitySibling controlsBetter bone mineral densityDual-energy X-ray absorptiometry (DXA) examinationDual-energy X-ray absorptiometryLower height Z-scoresHuman immunodeficiency virus-1Energy X-ray absorptiometryAdvanced HIV stageAge-adjusted percentileIndependent risk factorGender-adjusted z-scoresWeight z-scoreA Comparison of the Clinical and Cost-Effectiveness of 3 Intervention Strategies for AIDS Wasting
Shevitz AH, Wilson IB, McDermott AY, Spiegelman D, Skinner SC, Antonsson K, Layne JE, Beaston-Blaakman A, Shepard DS, Gorbach SL. A Comparison of the Clinical and Cost-Effectiveness of 3 Intervention Strategies for AIDS Wasting. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 38: 399-406. PMID: 15764956, DOI: 10.1097/01.qai.0000152647.89008.2b.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnabolic AgentsAntiretroviral Therapy, Highly ActiveBody CompositionCost-Benefit AnalysisDietFemaleHealth StatusHIV Wasting SyndromeHumansMaleMassachusettsMiddle AgedMuscle, SkeletalNutritional Physiological PhenomenaOxandrolonePhysical Education and TrainingQuality of LifeTreatment OutcomeConceptsProgressive resistance trainingCross-sectional muscle areaPhysical functioningCost-effective interventionAIDS wastingLeast cost-effective interventionBaseline physical functioningQuality of lifeInstitutional costsPlacebo pillsResistance trainingCaloric intakeProtein intakeBody compositionStrength training
2004
Changes in Body Weight and Body Fat Distribution as Risk Factors for Clinical Diabetes in US Men
Koh-Banerjee P, Wang Y, Hu FB, Spiegelman D, Willett WC, Rimm EB. Changes in Body Weight and Body Fat Distribution as Risk Factors for Clinical Diabetes in US Men. American Journal Of Epidemiology 2004, 159: 1150-1159. PMID: 15191932, DOI: 10.1093/aje/kwh167.Peer-Reviewed Original ResearchConceptsRisk of diabetesBody fat distributionFat distributionWeight gainBody weightHealth Professionals FollowCases of diabetesWaist gainClinical diabetesProfessionals FollowWaist circumferenceHip circumferenceRisk factorsSubsequent riskUS menDiabetesAbdominal fatWeight changeHip girthMenRiskCircumferenceWaistPercentPrevious studies
2002
Weight loss and body-composition changes in men and women infected with HIV 1 , 2 , 3
Forrester JE, Spiegelman D, Tchetgen E, Knox TA, Gorbach SL. Weight loss and body-composition changes in men and women infected with HIV 1 , 2 , 3. American Journal Of Clinical Nutrition 2002, 76: 1428-1434. PMID: 12450913, DOI: 10.1093/ajcn/76.6.1428.Peer-Reviewed Original ResearchRole of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men
Roubenoff R, Grinspoon S, Skolnik PR, Tchetgen E, Abad L, Spiegelman D, Knox T, Gorbach S. Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men. AJP Endocrinology And Metabolism 2002, 283: e138-e145. PMID: 12067854, DOI: 10.1152/ajpendo.00426.2001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntiretroviral Therapy, Highly ActiveBody CompositionBody WeightCD4 Lymphocyte CountCytokinesEnergy MetabolismFollow-Up StudiesHIV InfectionsHIV Wasting SyndromeHumansInterleukin-1Linear ModelsLongitudinal StudiesMaleMiddle AgedNutritional StatusRestTestosteroneThinnessTumor Necrosis Factor-alphaViral LoadConceptsLBM lossPeripheral blood mononuclear cellsIL-1 beta productionWeight lossActive antiretroviral therapyCohort of patientsSerum free testosteroneBlood mononuclear cellsInadequate dietary intakeOngoing cohort studyCytokine tumor necrosisRole of cytokinesIL-1 betaTNF-alpha productionInterleukin-1 betaMo of observationLean body massKcal/dayAntiretroviral therapyCohort studyFree testosteroneHIV infectionIndependent predictorsCytokine productionMononuclear cellsChanges in lean body mass and total body weight are weakly associated with physical functioning in patients with HIV infection
Wilson I, Jacobson D, Roubenoff R, Spiegelman D, Knox T, Gorbach S. Changes in lean body mass and total body weight are weakly associated with physical functioning in patients with HIV infection. HIV Medicine 2002, 3: 263-270. PMID: 12444944, DOI: 10.1046/j.1468-1293.2002.00122.x.Peer-Reviewed Original ResearchConceptsTotal body weightSelf-reported physical functioningPhysical functioningHIV infectionBody weightRelationship of changesCells/ micro l.Mean CD4 countHIV-positive personsMain outcome measuresLean body massLongitudinal analysisCD4 countCohort studyPositive personsOutcome measuresHealthy personsBody compositionPatientsStudy designWeight lossMicro l.InfectionWomenHealthy living
2001
Weight and body composition in a cohort of HIV-positive men and women
Forrester J, Spiegelman D, Woods M, Knox T, Fauntleroy J, Gorbach S. Weight and body composition in a cohort of HIV-positive men and women. Public Health Nutrition 2001, 4: 743-747. PMID: 11415480, DOI: 10.1079/phn200099.Peer-Reviewed Original Research
2000
Body Composition and Dietary Intake in Relation to Drug Abuse in a Cohort of HIV-Positive Persons
Forrester J, Woods M, Knox T, Spiegelman D, Skinner S, Gorbach S. Body Composition and Dietary Intake in Relation to Drug Abuse in a Cohort of HIV-Positive Persons. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 25: s43-s48. PMID: 11126426, DOI: 10.1097/00042560-200010001-00007.Peer-Reviewed Original ResearchConceptsBody mass indexIntravenous drug usersBody compositionDrug usersEnergy intakeDietary intakeFat massCurrent intravenous drug usersPast intravenous drug usersDrug abuseSelf-reported energy intakeHIV-positive personsHigher energy intakeBioelectrical impedance analysisCross-sectional analysisDrug use categoriesDrug use groupHIV infectionMass indexFood recordsDietary dataNonintravenous drugsNutritional statusIntakeWomenRelation of lean body mass to health-related quality of life in persons with HIV.
Wilson I, Roubenoff R, Knox T, Spiegelman D, Gorbach S. Relation of lean body mass to health-related quality of life in persons with HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 137-46. PMID: 10935689, DOI: 10.1097/00126334-200006010-00008.Peer-Reviewed Original ResearchConceptsGeneral health perceptionPhysical functionHealth-related qualityLean body massHigher lean body massHealth perceptionAssociated with better physical functionClinical impact of interventionsHealth-related quality of lifeDiverse population of personsBioimpedance analysisPatient self-reportBody massImpact of interventionsPopulation of personsCross-sectional analysisQuality of lifeIncreased LBMSelf-reportDiverse populationsEnergy/fatigueMultivariate modelHIVCD4 countHIV infectionRelation of Lean Body Mass to Health-Related Quality of Life in Persons With HIV
Wilson I, Roubenoff R, Knox T, Spiegelman D, Gorbach S. Relation of Lean Body Mass to Health-Related Quality of Life in Persons With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 137-146. DOI: 10.1097/00042560-200006010-00008.Peer-Reviewed Original ResearchConceptsLean body massHigher lean body massGeneral health perceptionEnergy/fatiguePhysical functioningHealth perceptionBetter general health perceptionBioimpedance analysisDesign Cross-sectional analysisMeasures of HRQLHealth-related qualityBody massLast monthBetter physical functioningQuality of lifeCross-sectional analysisCD4 countHIV infectionMean ageClinical impactMultivariable modelHIVCells/Number of daysWomen
1999
Elevated resting energy expenditure among HIV-seropositive persons receiving highly active antiretroviral therapy
Shevitz A, Knox T, Spiegelman D, Roubenoff R, Gorbach S, Skolnik P. Elevated resting energy expenditure among HIV-seropositive persons receiving highly active antiretroviral therapy. AIDS 1999, 13: 1351-1357. PMID: 10449288, DOI: 10.1097/00002030-199907300-00012.Peer-Reviewed Original ResearchConceptsFat-free massActive antiretroviral therapyHAART useHIV RNAAntiretroviral therapyCohort studyViral burdenKJ/dayHIV-seropositive menCD4 cell countHIV-seropositive personsLog10 copies/Energy expenditureLarge cohort studyIndependent effectsCross-sectional analysisHIV diseaseMedication regimensViral loadCopies/Adjusted REECell countElevated REEViral replicationHAART
1998
The effect of protease inhibitors on weight and body composition in HIV-infected patients
Silva M, Skolnik P, Gorbach S, Spiegelman D, Wilson I, Fernández-DiFranco M, Knox T. The effect of protease inhibitors on weight and body composition in HIV-infected patients. AIDS 1998, 12: 1645-1651. PMID: 9764784, DOI: 10.1097/00002030-199813000-00012.Peer-Reviewed Original ResearchConceptsLean body massPI therapyHIV infectionWeight gainViral loadPhysical functioningHealth perceptionBody compositionCurrent health perceptionsActive antiretroviral therapyPI treatmentProtease inhibitor therapyBody mass indexGreater weight gainHuman growth hormoneAntiretroviral therapyHIV cohortBody massInhibitor therapyMass indexOptimal therapyFat massAnabolic stimuliPatientsGrowth hormone
1992
Absolute fat mass, percent body fat, and body-fat distribution: which is the real determinant of blood pressure and serum glucose?
Spiegelman D, Israel R, Bouchard C, Willett W. Absolute fat mass, percent body fat, and body-fat distribution: which is the real determinant of blood pressure and serum glucose? American Journal Of Clinical Nutrition 1992, 55: 1033-1044. PMID: 1595574, DOI: 10.1093/ajcn/55.6.1033.Peer-Reviewed Original ResearchConceptsBody mass indexBlood pressurePercent body fatAbsolute fat massFat massSerum glucoseBody fatBlood glucoseDiastolic blood pressureBody fat distributionCigarette smoking statusCurrent cigarette smoking statusRegional fat distributionMultiple skinfold thicknessesRelative fat massMass indexFat distributionOverall body massSkinfold thicknessBody compositionStudy centersGold standardHip girthStrongest predictorUnderwater weighing