2021
Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database
Cheng E, Blackburn HN, Ng K, Spiegelman D, Irwin ML, Ma X, Gross CP, Tabung FK, Giovannucci EL, Kunz PL, Llor X, Billingsley K, Meyerhardt JA, Ahuja N, Fuchs CS. Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database. JAMA Network Open 2021, 4: e2112539. PMID: 34132794, PMCID: PMC8209612, DOI: 10.1001/jamanetworkopen.2021.12539.Peer-Reviewed Original ResearchConceptsEarly-onset colorectal cancerOnset colorectal cancerNational Cancer DatabaseColorectal cancerAge 51Overall survivalCancer DatabaseIncidence of CRCCox proportional hazards regressionPrimary colorectal cancerKaplan-Meier analysisProportional hazards regressionAge 50 yearsAge 25 yearsAnalysis of survivalCohort studySurvival benefitHazards regressionUnadjusted analysesCancer incidenceMAIN OUTCOMEAge 35Survival advantageLower riskStage I
2015
Sugar-sweetened beverage consumption and age at menarche in a prospective study of US girls
Carwile JL, Willett WC, Spiegelman D, Hertzmark E, Rich-Edwards J, Frazier AL, Michels KB. Sugar-sweetened beverage consumption and age at menarche in a prospective study of US girls. Human Reproduction 2015, 30: 675-683. PMID: 25628346, PMCID: PMC4325672, DOI: 10.1093/humrep/deu349.Peer-Reviewed Original ResearchConceptsFrequent SSB consumptionSugar-sweetened beverage consumptionServings of SSBsSSB consumptionEarly menarcheNational InstituteYouth/Adolescent Food Frequency QuestionnaireNurses' Health Study II participantsBeverage consumptionAdolescent Food Frequency QuestionnaireCox proportional hazards regressionBreast Cancer Research FoundationFood frequency questionnaireProspective cohort studyProportional hazards regressionFruit juice consumptionPARTICIPANTS/MATERIALSSugar-sweetened sodaAmerican Cancer SocietyROLE OF CHANCEPublic health effortsCancer Research FoundationNational Cancer InstituteToday StudyUS girls
2013
Dietary Patterns, Nutrient Intake, and Sociodemographic Characteristics in HIV-Infected Tanzanian Pregnant Women
Lukmanji Z, Hertzmark E, Spiegleman D, Fawzi WW. Dietary Patterns, Nutrient Intake, and Sociodemographic Characteristics in HIV-Infected Tanzanian Pregnant Women. Ecology Of Food And Nutrition 2013, 52: 34-62. PMID: 23282190, DOI: 10.1080/03670244.2012.705768.Peer-Reviewed Original ResearchConceptsPregnant womenNutrient intakeTanzanian pregnant womenWorld Health Organization recommendationsDietary macronutrient intakeLongitudinal clinical trialsVitamin supplementationClinical trialsDietary intakeMacronutrient intakeDietary patternsDiet intakeFood composition tablesHigh riskWomen's ageSociodemographic characteristicsIntakeInadequate foodDar es SalaamWomenHIVTwo-thirdsEducation levelComposition tablesAge
2005
Calculating deaths attributable to obesity.
Hu FB, Willett WC, Stampfer MJ, Spiegelman D, Colditz GA. Calculating deaths attributable to obesity. American Journal Of Public Health 2005, 95: 932; author reply 932-3. PMID: 15914810, PMCID: PMC1449281, DOI: 10.2105/ajph.2005.062836.Peer-Reviewed Original Research
2004
Early life menstrual characteristics and pregnancy experiences among women with and without major depression: the Harvard study of moods and cycles
Harlow BL, Cohen LS, Otto MW, Spiegelman D, Cramer DW. Early life menstrual characteristics and pregnancy experiences among women with and without major depression: the Harvard study of moods and cycles. Journal Of Affective Disorders 2004, 79: 167-176. PMID: 15023491, DOI: 10.1016/s0165-0327(02)00459-7.Peer-Reviewed Original ResearchConceptsRisk of depressionMajor depressionHeavy menstrual flowMenstrual cycle characteristicsMonths of breastfeedingNumber of livebirthsYears of menstruationCurrent major depressionHistory of depressionMost risk estimatesPopulation-based sampleYears of ageWomen 36Menstrual characteristicsGynecological careStudy enrollmentDecreased riskMenstrual flowMenstrual cyclePostpartum periodCycle irregularityPsychiatric sequelaePregnancy experiencePremenstrual dysphoriaMultiple abortionsReproductive Factors, Hormonal Contraception, and Risk of Uterine Leiomyomata in African-American Women: A Prospective Study
Wise LA, Palmer JR, Harlow BL, Spiegelman D, Stewart EA, Adams-Campbell LL, Rosenberg L. Reproductive Factors, Hormonal Contraception, and Risk of Uterine Leiomyomata in African-American Women: A Prospective Study. American Journal Of Epidemiology 2004, 159: 113-123. PMID: 14718211, PMCID: PMC1847588, DOI: 10.1093/aje/kwh016.Peer-Reviewed Original ResearchConceptsUS black womenUterine leiomyomataHormonal contraceptionReproductive factorsSelf-reported uterine leiomyomataProspective cohort studyBody mass indexIncidence rate ratiosCox regression modelSelf-reported diagnosisBlack womenAfrican American womenReproductive covariatesCohort studyPremenopausal womenAlcohol intakeMass indexProspective studyInverse associationHormonal factorsLast birthLeiomyomataReproductive historyNew casesFirst birth
2003
Vitamin C and risk of coronary heart disease in women
Osganian SK, Stampfer MJ, Rimm E, Spiegelman D, Hu FB, Manson JE, Willett WC. Vitamin C and risk of coronary heart disease in women. Journal Of The American College Of Cardiology 2003, 42: 246-252. PMID: 12875759, DOI: 10.1016/s0735-1097(03)00575-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAntioxidantsAscorbic AcidChemopreventionCoronary DiseaseDiabetes ComplicationsDietary SupplementsFemaleHumansHypercholesterolemiaHypertensionIncidenceLife StyleLogistic ModelsMiddle AgedMultivariate AnalysisNutrition SurveysProportional Hazards ModelsProspective StudiesRisk FactorsSmokingSurveys and QuestionnairesUnited StatesWomen's HealthConceptsRisk of CHDCoronary heart diseaseVitamin C intakeCoronary risk factorsVitamin C supplementsC intakeVitamin CC supplementsHeart diseaseRisk factorsLower riskDetailed semiquantitative food frequency questionnaireIncidence of CHDVitamin C supplement useIncident coronary heart diseaseSemiquantitative food frequency questionnaireFood frequency questionnaireSignificant inverse associationIncident casesSupplement useProspective InvestigationInverse associationProtective associationFemale nursesTotal intake
2001
Prospective study of dietary fat and the risk of age-related macular degeneration 1 , 2 , 3
Cho E, Hung S, Willett W, Spiegelman D, Rimm E, Seddon J, Colditz G, Hankinson S. Prospective study of dietary fat and the risk of age-related macular degeneration 1 , 2 , 3. American Journal Of Clinical Nutrition 2001, 73: 209-218. PMID: 11157315, DOI: 10.1093/ajcn/73.2.209.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationRisk of AMDTotal fat intakeFat intakeRelative riskHealth StudyPooled multivariate relative risksDiagnosis of AMDFish/wkModest inverse relationServings/moHealth Professionals FollowMultivariate relative riskNurses' Health StudyFood frequency questionnaireProfessionals FollowStudy of participantsProspective followVisual lossProspective studyLowest quintileDietary fatMacular degenerationHigh intakeLinolenic acid
2000
Prospective study of major dietary patterns and risk of coronary heart disease in men 1 , 2 , 3
Hu F, Rimm E, Stampfer M, Ascherio A, Spiegelman D, Willett W. Prospective study of major dietary patterns and risk of coronary heart disease in men 1 , 2 , 3. American Journal Of Clinical Nutrition 2000, 72: 912-921. PMID: 11010931, DOI: 10.1093/ajcn/72.4.912.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAlcohol DrinkingBody Mass IndexCohort StudiesCoronary DiseaseDietDiet RecordsDietary SupplementsExerciseFactor Analysis, StatisticalHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionProportional Hazards ModelsProspective StudiesRisk FactorsSmokingSurveys and QuestionnairesConceptsCoronary heart diseaseFood frequency questionnaireMajor dietary patternsRisk of CHDDietary patternsHeart diseaseRelative riskHigh intakePattern scoresCases of CHDHigh-fat dairy productsPrudent pattern scoresWestern pattern scoreCHD risk factorsProspective cohort studyOverall dietary patternsBody mass indexPrudent patternCohort studyCigarette smokingMass indexProspective studyHighest quintileMyocardial infarctionSubgroup analysis
1999
Association of age and reproductive factors with benign breast tissue composition.
Gertig DM, Stillman IE, Byrne C, Spiegelman D, Schnitt SJ, Connolly JL, Colditz GA, Hunter DJ. Association of age and reproductive factors with benign breast tissue composition. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 873-9. PMID: 10548315.Peer-Reviewed Original ResearchConceptsStromal proportionProliferative breast diseaseBreast diseaseRisk factorsBreast tissue compositionEpithelial proportionHealth StudyReproductive breast cancer risk factorsBenign breast biopsy slidesBreast cancer risk factorsObvious mass lesionStromal breast tissueNurses' Health StudyReproductive risk factorsCancer risk factorsBenign breast biopsyBreast cancer riskCase-control studyAssociation of agePostmenopausal parous womenFibrous stromal tissueNonproliferative breast diseasePostmenopausal womenPremenopausal womenParous womenA prospective study of carotenoid intake and risk of cataract extraction in US men
Brown L, Rimm E, Seddon J, Giovannucci E, Chasan-Taber L, Spiegelman D, Willett W, Hankinson S. A prospective study of carotenoid intake and risk of cataract extraction in US men. American Journal Of Clinical Nutrition 1999, 70: 517-524. PMID: 10500021, DOI: 10.1093/ajcn/70.4.517.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAlcohol DrinkingBeta CaroteneBrassicaCarotenoidsCataractCataract ExtractionCohort StudiesDiabetes ComplicationsDiet SurveysHumansLuteinMaleMiddle AgedMultivariate AnalysisProspective StudiesRisk FactorsSmokingSpinacia oleraceaSurveys and QuestionnairesUnited StatesVitamin AXanthophyllsZeaxanthinsConceptsCataract extractionLower riskUS male health professionalsDetailed dietary questionnairesMale health professionalsProspective epidemiologic dataProspective cohort studyIntake of carotenoidsRisk of cataractPotential risk factorsAge-related cataractSenile cataract extractionDietary questionnaireCohort studyZeaxanthin intakeHighest fifthProspective studyRisk factorsEpidemiologic dataHigh intakeCarotenoid intakeUS menDietary antioxidantsVitamin AHealth professionalsEvaluation of a Population Roster as a Source of Population Controls: The Massachusetts Resident Lists
Bohlke K, Harlow B, Cramer D, Spiegelman D, Mueller N. Evaluation of a Population Roster as a Source of Population Controls: The Massachusetts Resident Lists. American Journal Of Epidemiology 1999, 150: 354-358. PMID: 10453811, DOI: 10.1093/oxfordjournals.aje.a010014.Peer-Reviewed Original ResearchPrevalence and Predictors of Depressive Symptoms in Older Premenopausal Women: The Harvard Study of Moods and Cycles
Harlow BL, Cohen LS, Otto MW, Spiegelman D, Cramer DW. Prevalence and Predictors of Depressive Symptoms in Older Premenopausal Women: The Harvard Study of Moods and Cycles. JAMA Psychiatry 1999, 56: 418-424. PMID: 10232296, DOI: 10.1001/archpsyc.56.5.418.Peer-Reviewed Original ResearchConceptsDepressive symptomsPremenstrual symptomsCommunity-based cohort studyOlder premenopausal womenMenstrual cycle irregularityPrevalence of depressionCommunity-based studyCES-D scoresCurrent depressive symptomsSelf-administered questionnaireCohort studyPremenopausal womenNulliparous womenUpper tertileCigarette smokingMenstrual historyOvarian functionHarvard StudyCycle irregularityMajor depressionMood disordersLower riskDepression scoresDepression historySymptoms
1998
A prospective study of physical activity and prostate cancer in male health professionals.
Giovannucci E, Leitzmann M, Spiegelman D, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. A prospective study of physical activity and prostate cancer in male health professionals. Cancer Research 1998, 58: 5117-22. PMID: 9823321.Peer-Reviewed Original ResearchConceptsMale health professionalsTotal prostate cancerMetastatic prostate cancerProstate cancerPhysical activityMetabolic equivalentsVigorous activityLower riskHealth professionalsLeisure-time physical activityMore metabolic equivalentsNonvigorous physical activityReported average timeHealth Professionals FollowHistory of diabetesProspective cohort studyAdvanced prostate cancerRole of exerciseTime physical activityYears of ageWarrants further studyNonvigorous activitiesMen 40Professionals FollowCohort studyPhysical Activity and Breast Cancer Risk in a Cohort of Young Women
Rockhill B, Willett W, Hunter D, Manson J, Hankinson S, Spiegelman D, Colditz G. Physical Activity and Breast Cancer Risk in a Cohort of Young Women. Journal Of The National Cancer Institute 1998, 90: 1555-1160. PMID: 9701365, DOI: 10.1093/jnci/90.15.1155.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study IIPhysical activityRelative riskBreast cancerCancer riskNurses' Health Study IIRR of cancerBreast cancer preventionInvasive breast cancerStrenuous physical activityConfidence intervalsLate adolescenceNonoccupational physical activityYoung adult womenProspective studyNonoccupational activitiesActive womenCancer preventionReduced riskStrenuous activityAdult womenAge 18Logistic regressionYoung womenThe relation of physical activity to risk for symptomatic gallstone disease in men.
Leitzmann MF, Giovannucci EL, Rimm EB, Stampfer MJ, Spiegelman D, Wing AL, Willett WC. The relation of physical activity to risk for symptomatic gallstone disease in men. Annals Of Internal Medicine 1998, 128: 417-25. PMID: 9499324, DOI: 10.7326/0003-4819-128-6-199803150-00001.Peer-Reviewed Original ResearchConceptsSymptomatic gallstone diseaseGallstone diseasePhysical activityYears of ageSymptomatic gallstonesBody weightU.S. male health professionalsMale health professionalsProspective cohort studyUse of medicationsMen 65 yearsStrong inverse associationBiliary eventsMen 40Cohort studySmoking habitsExtreme quintilesAlcohol intakeRecent symptomsInverse associationMultiple confoundersMedical conditionsSedentary behaviorHigh riskHealth professionalsCigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study.
Ishibe N, Hankinson SE, Colditz GA, Spiegelman D, Willett WC, Speizer FE, Kelsey KT, Hunter DJ. Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study. Cancer Research 1998, 58: 667-71. PMID: 9485019.Peer-Reviewed Original ResearchConceptsBreast cancer riskNurses' Health StudyCigarette smokingBreast cancerCancer riskHealth StudyAryl hydrocarbon hydroxylase activityRelative riskCYP1A1 polymorphismsIncident breast cancer casesHydroxylase activityVariant CYP1A1 genotypesBreast cancer ratesBreast cancer incidenceConfidence intervalsCytochrome P450 1A1 (CYP1A1) polymorphismsCase-control studyConditional logistic regressionBreast cancer casesExon 7 polymorphismHomozygous wild typeSusceptible womenModifiable causesCancer incidenceCaucasian women
1997
Oral Contraceptives and Ovulatory Causes of Delayed Fertility
Chasan-Taber L, Willett W, Stampfer M, Spiegelman D, Rosner B, Hunter D, Colditz G, Manson J. Oral Contraceptives and Ovulatory Causes of Delayed Fertility. American Journal Of Epidemiology 1997, 146: 258-265. PMID: 9247010, DOI: 10.1093/oxfordjournals.aje.a009261.Peer-Reviewed Original ResearchConceptsOvulatory causeOral contraceptivesMultivariate relative riskOral contraceptive useReturn of fertilityHistory of infertilityCase-control studyPercent of casesDuration of useMethod of contraceptionOvulatory infertilityPrevious pregnancyEventual pregnancyHormonal disordersRelative riskContraceptive useYounger agePregnancyMarried nursesNursesWomenContraceptivesInfertilityDelayed fertilityFirst useRisk Factors for Postherpetic Neuralgia
Choo PW, Galil K, Donahue JG, Walker AM, Spiegelman D, Platt R. Risk Factors for Postherpetic Neuralgia. JAMA Internal Medicine 1997, 157: 1217-1224. PMID: 9183233, DOI: 10.1001/archinte.1997.00440320117011.Peer-Reviewed Original ResearchConceptsOnset of zosterPostherpetic neuralgiaRisk factorsHerpes zosterCases of PHNTreatment of zosterHealth maintenance organizationSystemic acyclovirSystemic corticosteroidsElderly patientsPharmacy recordsCommon complicationSensory symptomsProdromal symptomsHigh prevalenceZosterEligibility criteriaMaintenance organizationPatientsPrevalenceTreatment factorsCorticosteroidsNeuralgiaAcyclovirSymptomsA Prospective Study of Oral Contraceptives and NIDDM Among U.S. Women
Chasan-Taber L, Willett W, Stampfer M, Hunter D, Colditz G, Spiegelman D, Manson J. A Prospective Study of Oral Contraceptives and NIDDM Among U.S. Women. Diabetes Care 1997, 20: 330-335. PMID: 9051382, DOI: 10.2337/diacare.20.3.330.Peer-Reviewed Original ResearchConceptsOral contraceptivesRelative riskPast usersProspective studyModern oral contraceptivesU.S. female nursesMultivariate relative riskOral contraceptive useProspective cohort studyLarge prospective studiesLow absolute riskCoronary heart diseaseCurrent usersHistory of diagnosisDiagnosed diabetesCohort studyElevated cholesterolAlcohol intakeCigarette smokingIncident casesSymptomatic casesAbsolute riskExcess riskHeart diseaseFamily history