2022
Slip versus Slop: A Head-to-Head Comparison of UV-Protective Clothing to Sunscreen
Berry EG, Bezecny J, Acton M, Sulmonetti TP, Anderson DM, Beckham HW, Durr RA, Chiba T, Beem J, Brash DE, Kulkarni R, Cassidy PB, Leachman SA. Slip versus Slop: A Head-to-Head Comparison of UV-Protective Clothing to Sunscreen. Cancers 2022, 14: 542. PMID: 35158810, PMCID: PMC8833350, DOI: 10.3390/cancers14030542.Peer-Reviewed Original ResearchImportant modifiable risk factorModifiable risk factorsSun-protective clothingSkin cancer developmentUltraviolet radiation exposureRisk factorsSun protection factorProtection factorUV-protective clothingBroad-spectrum protectionHead comparisonCancer developmentUV-protective capacityRadiation exposureUVR exposureUVR protectionSunscreensOrganic sunscreensExposureUVRHeadFactors
2005
Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-xL reduction thereby enhancing UV-light induced apoptosis
Chaturvedi V, Sitailo LA, Qin JZ, Bodner B, Denning MF, Curry J, Zhang W, Brash D, Nickoloff BJ. Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-xL reduction thereby enhancing UV-light induced apoptosis. Oncogene 2005, 24: 5299-5312. PMID: 15940268, DOI: 10.1038/sj.onc.1208650.Peer-Reviewed Original ResearchConceptsMouse modelP53 levelsP53 siRNAHuman keratinocytesMcl-1Skin cancer developmentKnockout mouse modelP53 tumor suppressor geneCultured human keratinocytesBcl-xL antiapoptotic proteinBcl-xL levelsCommon causeParadoxical responseSkin cancerAccelerated eliminationUltraviolet light exposureWild-type p53Cancer developmentTumor suppressor geneUV-induced DNA damageEpidermal responseE2F-1 levelsPrimary culturesSiRNA-based approachAbnormal cells