Abstract 5104: Identification of key tumorigenic pathways in pancreatic adenocarcinoma patients using massively parallel DNA and RNA sequencing
Liang W, Craig D, Carpten J, Borad M, Demeure M, Weiss G, Kiefer J, Posner R, Hostetter G, Izatt T, Sinari S, Christoforides A, Aldrich J, Kurdoglu A, Phillips L, Benson H, Baker A, Han H, Lake D, Stites E, Ramanathan R, Fonseca R, Stewart A, Hoff D. Abstract 5104: Identification of key tumorigenic pathways in pancreatic adenocarcinoma patients using massively parallel DNA and RNA sequencing. Cancer Research 2012, 72: 5104-5104. DOI: 10.1158/1538-7445.am2012-5104.Peer-Reviewed Original ResearchNext-generation sequencing technologiesWhole-genome sequencingWhole-transcriptome sequencingPancreatic adenocarcinoma patientsChromosomal copy number variantsMassively parallel DNACopy number variantsPancreatic cancer pathwayAdenocarcinoma patientsPancreatic adenocarcinomaGlobal pathway analysisGenome sequenceSequencing technologiesTranscriptome sequencingPinpointing genesAmerican Association for Cancer ResearchKRAS signaling pathwayMultiple genesPoint mutationsRNA sequencingParallel DNASomatic eventsPathway analysisSignaling pathwayCancer pathways