2023
QOL-09. QUALITY OF LIFE AFTER SURGERY FOR LOWER GRADE GLIOMAS
Heffernan A, Wu Y, Benz L, Verhaak R, Kwan B, Claus E. QOL-09. QUALITY OF LIFE AFTER SURGERY FOR LOWER GRADE GLIOMAS. Neuro-Oncology 2023, 25: v250-v250. PMCID: PMC10639580, DOI: 10.1093/neuonc/noad179.0961.Peer-Reviewed Original ResearchLow-grade gliomasGrade gliomasNon-malignant brain tumoursShort Form Health SurveyBackground Limited dataForm Health SurveyGeneral healthy populationGroup of patientsMedical Outcomes StudyCase/control studyLong-term qualityTime of interviewResidents of ConnecticutQOL outcomesSample average ageHealth SurveyOutcome studiesMeningioma casesTreatment groupsBrain tumorsAverage ageControl studyHealthy populationControl populationPrime of life
2019
Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk
Muskens IS, Hansen HM, Smirnov IV, Molinaro AM, Bondy ML, Schildkraut JM, Wrensch M, Wiemels JL, Claus EB. Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk. Journal Of Neuro-Oncology 2019, 142: 479-487. PMID: 30796745, PMCID: PMC6482066, DOI: 10.1007/s11060-019-03119-w.Peer-Reviewed Original ResearchConceptsMeningioma riskBrain tumorsNon-malignant brain tumoursMalignant brain tumorsEtiology of meningiomaHealthy controlsOdds ratioMeningioma patientsMeningioma casesSurvival rateLogistic regressionMeningiomasGermline DNATelomere lengthTumorsMultiple testingRiskEuropean ancestryWestern European ancestryPatientsPathophysiologyLymphocytesConclusionIncreasedEtiologyControl
2015
Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma
Ramkissoon SH, Bi WL, Schumacher SE, Ramkissoon LA, Haidar S, Knoff D, Dubuc A, Brown L, Burns M, Cryan JB, Abedalthagafi M, Kang YJ, Schultz N, Reardon DA, Lee EQ, Rinne ML, Norden AD, Nayak L, Ruland S, Doherty LM, LaFrankie DC, Horvath M, Aizer AA, Russo A, Arvold ND, Claus EB, Al-Mefty O, Johnson MD, Golby AJ, Dunn IF, Chiocca EA, Trippa L, Santagata S, Folkerth RD, Kantoff P, Rollins BJ, Lindeman NI, Wen PY, Ligon AH, Beroukhim R, Alexander BM, Ligon KL. Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. Neuro-Oncology 2015, 17: 1344-1355. PMID: 25754088, PMCID: PMC4578577, DOI: 10.1093/neuonc/nov015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBrain NeoplasmsChildChild, PreschoolComparative Genomic HybridizationDNA Copy Number VariationsFemaleGene Expression ProfilingGenome-Wide Association StudyGenotypeGlioblastomaHumansInfantIsocitrate DehydrogenaseMaleMiddle AgedMutationProspective StudiesPTEN PhosphohydrolaseTumor Suppressor Protein p53Young AdultConceptsClinical trialsBrain tumorsGlioblastoma patientsClinical settingClinical Laboratory Improvement AmendmentsParaffin-embedded samplesWhole-genome array comparative genomic hybridizationWhole gene sequencingTherapeutic trialsWhole-genome copy numberClinical testing resultsPatientsClinical diagnosisMutation profilingIntegral biomarkerArray comparative genomic hybridizationGlioblastomaClinical implementationTrialsComparative genomic hybridizationTumor suppressor inactivationCopy numberTumorsFFPE samplesDiagnostic laboratories
2014
Germline Mutations in Shelterin Complex Genes Are Associated With Familial Glioma
Bainbridge MN, Armstrong GN, Gramatges MM, Bertuch AA, Jhangiani SN, Doddapaneni H, Lewis L, Tombrello J, Tsavachidis S, Liu Y, Jalali A, Plon SE, Lau CC, Parsons DW, Claus EB, Barnholtz-Sloan J, Il’yasova D, Schildkraut J, Ali-Osman F, Sadetzki S, Johansen C, Houlston RS, Jenkins RB, Lachance D, Olson SH, Bernstein JL, Merrell RT, Wrensch MR, Walsh KM, Davis FG, Lai R, Shete S, Aldape K, Amos CI, Thompson PA, Muzny DM, Gibbs RA, Melin BS, Bondy ML, Consortium T. Germline Mutations in Shelterin Complex Genes Are Associated With Familial Glioma. Journal Of The National Cancer Institute 2014, 107: dju384. PMID: 25482530, PMCID: PMC4296199, DOI: 10.1093/jnci/dju384.Peer-Reviewed Original ResearchConceptsShelterin complex genesDNA bindingComplex genesFamilial gliomaWhole-exome sequencingPOT1 mutationsCommon brain tumorTreatment of gliomaGenetic contributionAdditional mutationsOrigin of gliomasMutationsPOT1TPP1Exome sequencingHistological subtypesMalignancy gradeSeparate cohortBrain tumorsSpecific subtypesFuture diagnosticsGermline mutationsGliomasFamilySubtypes
2012
Dental x‐rays and risk of meningioma
Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Dental x‐rays and risk of meningioma. Cancer 2012, 118: 4530-4537. PMID: 22492363, PMCID: PMC3396782, DOI: 10.1002/cncr.26625.Peer-Reviewed Original ResearchConceptsRisk of meningiomaDental X-raysModifiable risk factorsIntracranial meningiomasRisk factorsAge 20Population-based case-control studyMain outcome measuresPrimary brain tumorsCase-control studyGreater frequencyPanorex filmsTumor locationBitewing examinationOutcome measuresElevated riskBrain tumorsControl groupMeningiomasYounger ageRadiation exposureAge 10AgePatientsRisk
2011
Family and personal medical history and risk of meningioma.
Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Family and personal medical history and risk of meningioma. Journal Of Neurosurgery 2011, 115: 1072-7. PMID: 21780859, PMCID: PMC3241000, DOI: 10.3171/2011.6.jns11129.Peer-Reviewed Original ResearchConceptsFirst-degree family historyPersonal medical historyMedical historyFamily historyMeningioma riskEpidemiology of meningiomaPrimary brain tumorsCase-control studyRisk of meningiomaUterine fibroid tumorsImmune conditionsThyroid cancerYoungest caseBreast cancerRole of hormonesBrain tumorsFibroid tumorsImmune systemControl individualsPatientsMeningiomasInfluence of geneticsStrong associationFurther studiesTumors