2024
Multi-day vs single-day dexamethasone for the prophylaxis of chemotherapy-induced nausea and vomiting: systematic review and meta-analysis
Chow R, Celio L, Im J, Caini S, Eng L, Prsic E, Scotté F, Aapro M. Multi-day vs single-day dexamethasone for the prophylaxis of chemotherapy-induced nausea and vomiting: systematic review and meta-analysis. Supportive Care In Cancer 2024, 32: 736. PMID: 39432169, DOI: 10.1007/s00520-024-08934-0.Peer-Reviewed Original ResearchConceptsDexamethasone-sparing regimenChemotherapy-induced nausea and vomitingModerately emetogenic chemotherapyHighly emetogenic chemotherapyRandomized controlled trialsComplete responseMeta-analysisEmetogenic chemotherapyNo vomitingRescue medicationProphylaxis of chemotherapy-induced nausea and vomitingSystematic reviewSchedule of dexamethasoneNausea and vomitingChemotherapy-induced nauseaResultsTen trialsAntiemetic regimenCumulative meta-analysisEffect estimatesSafety profileComprehensive systematic reviewMethodsOvid MEDLINERegimensAdult cancer patientsCancer patientsAssociation of patient socioeconomic status with outcomes after palliative treatment for disseminated cancer
Maduka R, Canavan M, Walters S, Ermer T, Zhan P, Kaminski M, Li A, Pichert M, Salazar M, Prsic E, Boffa D. Association of patient socioeconomic status with outcomes after palliative treatment for disseminated cancer. Cancer Medicine 2024, 13: e7028. PMID: 38711364, PMCID: PMC11074703, DOI: 10.1002/cam4.7028.Peer-Reviewed Original ResearchConceptsOptimal quality of careQuality of carePatient socioeconomic statusAssociated with improved qualityAssociated with improved quality of lifeEnd-of-lifeUS cancer populationPalliative treatmentQuality of lifeCox proportional hazards modelsMultivariate logistic regressionInformed decision makingProportional hazards modelFacility characteristicsNon-HispanicAssociated with lower ratesInsurance payer statusImproving informed decision makingCancer populationSocioeconomic statusHispanic ethnicityTreatment usePayer statusBlack raceLogistic regression
2023
Oncology hospitalist impact on hospice utilization
Prsic E, Morris J, Adelson K, Parker N, Gombos E, Kottarathara M, Novosel M, Castillo L, Rothberg BE. Oncology hospitalist impact on hospice utilization. Cancer 2023, 129: 3797-3804. PMID: 37706601, DOI: 10.1002/cncr.35008.Peer-Reviewed Original ResearchConceptsMedical oncology serviceOncology servicesEnd of lifeAdvanced cancerInpatient hospiceHospice utilizationHigher total health care costsTotal health care costsComfort-focused careInpatient oncology serviceSmilow Cancer HospitalAdjusted odds ratioLength of staySolid tumor malignanciesLong-term survivalMultivariable linear regressionHealth care costsElectronic medical recordsHospice transitionUnplanned hospitalizationDischarge dispositionHospice referralInpatient managementLate referralCancer HospitalPrevalence and predictors of long-delayed (> 120 h) chemotherapy-induced nausea and vomiting (CINV)—a systematic review and individual patient data meta-analysis
Chow R, Yin L, Baqri W, Huang R, Boldt G, Younus J, Lock M, Prsic E, Zimmermann C, Herrstedt J. Prevalence and predictors of long-delayed (> 120 h) chemotherapy-induced nausea and vomiting (CINV)—a systematic review and individual patient data meta-analysis. Supportive Care In Cancer 2023, 31: 505. PMID: 37535218, DOI: 10.1007/s00520-023-07978-y.Peer-Reviewed Original ResearchConceptsChemotherapy-induced nauseaIndividual patient dataDay 4Individual patient-level dataPatient dataPatient-level dataStepwise logistic regressionEmetogenic chemotherapyChemotherapy regimenChemotherapy regimensPatient demographicsCochrane CENTRALResultsA totalOverall prevalenceCINVNauseaVomitingPatientsEligible articlesSystematic reviewAntineoplastic agentsStudy authorsLogistic regressionMethodsThis reviewSignificant riskLung Cancer Supportive Care and Symptom Management
Yao J, Novosel M, Bellampalli S, Kapo J, Joseph J, Prsic E. Lung Cancer Supportive Care and Symptom Management. Hematology/Oncology Clinics Of North America 2023, 37: 609-622. PMID: 37024385, DOI: 10.1016/j.hoc.2023.02.011.Peer-Reviewed Original ResearchOutcomes on an inpatient oncology service after the introduction of hospitalist comanagement
Morris J, Rothberg BE, Prsic E, Parker N, Weber U, Gombos E, Kottarathara M, Billingsley K, Adelson K. Outcomes on an inpatient oncology service after the introduction of hospitalist comanagement. Journal Of Hospital Medicine 2023, 18: 391-397. PMID: 36891947, DOI: 10.1002/jhm.13071.Peer-Reviewed Original ResearchConceptsLength of stayInpatient oncology serviceSmilow Cancer HospitalSeverity of illnessOncology servicesOncologists' experiencesReadmission ratesEarly dischargeHospitalist comanagementAverage LOSTime of dischargeMean discharge timeEarly discharge ratesImpact of hospitalistsRace/ethnicityDischarge dispositionMultiple admissionsCancer HospitalMAIN OUTCOMEStudy durationPatient volumeCancer typesStudy periodHospitalistsOutcomes
2022
End-of-life care trajectories among older adults with lung cancer
Davidoff AJ, Canavan ME, Prsic E, Saphire M, Wang SY, Presley CJ. End-of-life care trajectories among older adults with lung cancer. Journal Of Geriatric Oncology 2022, 14: 101381. PMID: 36202695, PMCID: PMC9974538, DOI: 10.1016/j.jgo.2022.09.010.Peer-Reviewed Original ResearchConceptsCancer-directed therapyLung cancerCare trajectoriesOlder adultsSupportive care servicesSEER-Medicare dataSkilled nursing facilitiesNon-Hispanic whitesRace/ethnicityCancer decedentsSymptom managementIntensive careOlder decedentsConcurrent careHospice careReferral regionsHigh riskMultinomial logistic regressionNursing facilitiesMedicare decedentsCare servicesLogistic regressionCancerHospiceDecedentsDuloxetine for prevention and treatment of chemotherapy-induced peripheral neuropathy (CIPN): systematic review and meta-analysis
Chow R, Novosel M, So OW, Bellampalli S, Xiang J, Boldt G, Winquist E, Lock M, Lustberg M, Prsic E. Duloxetine for prevention and treatment of chemotherapy-induced peripheral neuropathy (CIPN): systematic review and meta-analysis. BMJ Supportive & Palliative Care 2022, 13: 27-34. PMID: 36194493, DOI: 10.1136/spcare-2022-003815.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyTreatment of CIPNDuloxetine usePeripheral neuropathyRisk ratioPrevention of CIPNSystematic reviewUse of duloxetineSummary risk ratiosClinical practice recommendationsHigh-quality trialsDerSimonian-Laird modelComprehensive systematic reviewCochrane CENTRALSafety profileDatabase inceptionHuman trialsDuloxetinePractice recommendationsLimited evidencePreventionTrialsNeuropathyTreatmentReviewAssociation Between Postdischarge Medical Oncology Follow-Up Appointments and Downstream Health Care Use: A Single-Institution Experience
Xiang J, Chow R, Reynoso A, Carafeno T, Deshpande H, Strait M, Prsic E. Association Between Postdischarge Medical Oncology Follow-Up Appointments and Downstream Health Care Use: A Single-Institution Experience. JCO Oncology Practice 2022, 18: e1466-e1474. PMID: 35696632, DOI: 10.1200/op.21.00868.Peer-Reviewed Original ResearchConceptsHealth care useED visitsCare useOncology appointmentsAppointment timingPropensity score-matched analysisMultivariable logistic regression modelYale-New Haven HospitalRetrospective cohort studySingle institution experienceEmergency department visitsTertiary academic centerNew Haven HospitalLower ratesLogistic regression modelsOncology admissionsOncology followCause readmissionMost admissionsCohort studyDepartment visitsMedical oncologySubgroup analysisReadmissionAcademic centers
2021
Medical Outcomes of Oncology Inpatients With and Without Chaplain Spiritual Care Visit: The Yale New Haven Hospital Experience
Chow R, Tenenbaum L, Balboni TA, Prsic EH. Medical Outcomes of Oncology Inpatients With and Without Chaplain Spiritual Care Visit: The Yale New Haven Hospital Experience. JCO Oncology Practice 2021, 18: e334-e338. PMID: 34846912, DOI: 10.1200/op.21.00600.Peer-Reviewed Original ResearchConceptsMedical oncology patientsHealth care utilizationCare utilizationSpiritual careCare visitsOncology patientsIntensive care unit admissionYale-New Haven HospitalHospital health outcomesSpiritual care assessmentCare unit admissionDays of dischargeRetrospective chart reviewEmergency department visitsLength of stayNew Haven HospitalQuality of lifeUnit admissionHospital deathHospital outcomesChart reviewOncology inpatientsReadmission ratesDepartment visitsCare consultationsOlanzapine 5 mg vs 10 mg for the prophylaxis of chemotherapy-induced nausea and vomiting: a network meta-analysis
Chow R, Navari RM, Terry B, DeAngelis C, Prsic EH. Olanzapine 5 mg vs 10 mg for the prophylaxis of chemotherapy-induced nausea and vomiting: a network meta-analysis. Supportive Care In Cancer 2021, 30: 1015-1018. PMID: 34613472, DOI: 10.1007/s00520-021-06606-x.Peer-Reviewed Original ResearchCancer-related fatigue—pharmacological interventions: systematic review and network meta-analysis
Chow R, Bruera E, Sanatani M, Chiu L, Prsic E, Boldt G, Lock M. Cancer-related fatigue—pharmacological interventions: systematic review and network meta-analysis. BMJ Supportive & Palliative Care 2021, 13: 274-280. PMID: 34593386, DOI: 10.1136/bmjspcare-2021-003244.Peer-Reviewed Original ResearchConceptsCancer-related fatiguePharmacologic interventionsSystematic reviewCochrane Central RegisterFuture clinical trialsMore safety dataCentral RegisterHead trialsControlled TrialsCommon symptomsFuture trialsClinical trialsSafety dataDirect headMean differenceParoxetineModafinilTrialsInterventionPatientsCancer researchReviewPlaceboEMBASEMEDLINEMusic therapy effectiveness by duration in patients with cancer: a meta-regression
Chow R, Bergner R, Prsic E. Music therapy effectiveness by duration in patients with cancer: a meta-regression. BMJ Supportive & Palliative Care 2021, 13: 117-120. PMID: 36810298, DOI: 10.1136/bmjspcare-2021-003163.Peer-Reviewed Original ResearchConceptsTherapy timeMusic therapyMusic therapy's effectivenessOutcomes of painBetter pain controlPatient-related outcomesInverse variance modelHigh-quality studiesQuality of lifePain controlLower riskTherapy effectivenessBias trialsTherapyPainPatientsCancerLonger durationEmotional wellPositive associationDurationOutcomesHoursTrialsEndpointThe value of triggered geriatrics and palliative care consults in hospital medicine during the COVID-19 response
Prsic EH, Ouellet JA, Lai JM. The value of triggered geriatrics and palliative care consults in hospital medicine during the COVID-19 response. Annals Of Palliative Medicine 2021, 0: 50-50. PMID: 33615802, DOI: 10.21037/apm-20-2297.Peer-Reviewed Original ResearchEnd-of-life patterns of symptom management and cancer-directed care among Medicare beneficiaries with lung cancer: a claims-based analysis
Davidoff AJ, Canavan ME, Prsic E, Saphire M, Wang SY, Presley CJ. End-of-life patterns of symptom management and cancer-directed care among Medicare beneficiaries with lung cancer: a claims-based analysis. Supportive Care In Cancer 2021, 29: 3921-3932. PMID: 33389087, DOI: 10.1007/s00520-020-05964-2.Peer-Reviewed Original ResearchConceptsCancer-directed therapySymptom management servicesLung cancerMedicare beneficiariesCare contentYounger ageEarlier hospice enrollmentLife care patternsLung cancer decedentsPercentage of patientsClaims-based analysisMethodsThis retrospective studyMost Medicare beneficiariesNonhospice settingsCancer decedentsUsual careHospice enrollmentSymptom managementRetrospective studyMedicare databaseSkilled nursingHigh comorbidityCare intensityMedicare claimsMultinomial logistic regression
2020
Serotonin Syndrome in Palliative Care #403
Chow R, Kozhevnikov D, Prsic EH. Serotonin Syndrome in Palliative Care #403. Journal Of Palliative Medicine 2020, 23: 1678-1680. PMID: 33306009, DOI: 10.1089/jpm.2020.0492.Peer-Reviewed Original Research
2019
Patterns of Symptom Management Medication Receipt at End-of-Life Among Medicare Beneficiaries With Lung Cancer
Saphire ML, Prsic E, Canavan ME, Wang SJ, Presley CJ, Davidoff AJ. Patterns of Symptom Management Medication Receipt at End-of-Life Among Medicare Beneficiaries With Lung Cancer. Journal Of Pain And Symptom Management 2019, 59: 767-777.e1. PMID: 31778783, PMCID: PMC7338983, DOI: 10.1016/j.jpainsymman.2019.11.015.Peer-Reviewed Original ResearchConceptsNausea/vomitingMedication receiptEnd of lifeLung cancerOutpatient settingOlder adultsEnd Results-Medicare databaseEmotional distressPoor patient-provider communicationReceipt of medicationSymptom management medicationsHigh symptom burdenAge 67 yearsPatient demographic characteristicsMultivariable logistic regressionPatient-provider communicationMedicare hospice benefitOutpatient medicationsConcurrent therapyRetrospective cohortSymptom burdenSymptomatic managementHospice enrollmentSymptom managementD claims