2024
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children
Watkins T, Green A, Amat J, Cheemarla N, Hänsel K, Lozano R, Dudgeon S, Germain G, Landry M, Schulz W, Foxman E. High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children. Journal Of Experimental Medicine 2024, 221: e20230911. PMID: 38949638, PMCID: PMC11215523, DOI: 10.1084/jem.20230911.Peer-Reviewed Original ResearchConceptsBacterial pathobiontsRespiratory virusesBurden of virusesSARS-CoV-2Innate immune activationSARS-CoV-2 viral loadDynamic host-pathogen interactionsInnate immune responseViral coinfectionCytokine profileViral loadNasal virusImmune activationProinflammatory responseIL-1BNasopharyngeal samplesHost-pathogen interactionsImmune responseInterferon responsePathobiontsInnate immunityPaired samplesCXCL10Healthy 1-year-oldVirus
2020
An in vivo atlas of host–pathogen transcriptomes during Streptococcus pneumoniae colonization and disease
D’Mello A, Riegler AN, Martínez E, Beno SM, Ricketts TD, Foxman EF, Orihuela CJ, Tettelin H. An in vivo atlas of host–pathogen transcriptomes during Streptococcus pneumoniae colonization and disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 33507-33518. PMID: 33318198, PMCID: PMC7777036, DOI: 10.1073/pnas.2010428117.Peer-Reviewed Original ResearchConceptsStreptococcus pneumoniae colonizationHost gene expression profilesHost defense pathwaysOrgan damagePneumoniae colonizationProinflammatory responseInvasive diseaseAnatomical sitesTherapeutic targetInterferon responseDisease statesDiseaseGene expression profilesLungOrgan-specific mannerVivoPneumoniaPathogenesisKidneyBloodResponse