2024
Non-invasive preimplantation genetic testing for aneuploidy: is the promise real?
Volovsky M, Scott R, Seli E. Non-invasive preimplantation genetic testing for aneuploidy: is the promise real? Human Reproduction 2024, 39: 1899-1908. PMID: 38970367, DOI: 10.1093/humrep/deae151.Peer-Reviewed Original ResearchNon-invasive PGT-APGT-APreimplantation genetic testingIntegration of next-generation sequencingGenetic testingGenetic testing platformsNon-invasive preimplantation genetic testingNext-generation sequencingRisk of pregnancy lossAneuploidy screening methodsEmbryo culture mediumAmplification failureSegmental aneuploidyPregnancy lossCulture mediumClinical reliabilityAneuploidyDiagnostic precisionClinical settingDiagnostic inaccuracyEmbryo viabilityClinical adoptionEmbryosScreening methodDNA
2021
Preimplantation genetic testing to evaluate for mitochondrial deoxyribonucleic acid disease and aneuploidy: a two-birds-with-one-stone approach
Hanson BM, Seli E. Preimplantation genetic testing to evaluate for mitochondrial deoxyribonucleic acid disease and aneuploidy: a two-birds-with-one-stone approach. Fertility And Sterility 2021, 115: 1439-1440. PMID: 33795137, DOI: 10.1016/j.fertnstert.2021.03.006.Peer-Reviewed Original Research
2020
Developmental potential of aneuploid human embryos cultured beyond implantation
Shahbazi MN, Wang T, Tao X, Weatherbee BAT, Sun L, Zhan Y, Keller L, Smith GD, Pellicer A, Scott RT, Seli E, Zernicka-Goetz M. Developmental potential of aneuploid human embryos cultured beyond implantation. Nature Communications 2020, 11: 3987. PMID: 32778678, PMCID: PMC7418029, DOI: 10.1038/s41467-020-17764-7.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyAntigens, CDCadherinsCell AdhesionCell Cycle CheckpointsCell LineageChromosome SegregationChromosomes, Human, Pair 16Chromosomes, Human, Pair 21Embryo ImplantationEmbryo, MammalianEmbryonic DevelopmentFemaleGenes, erbB-1Genetic TestingHumansMonosomyMosaicismPregnancyStem CellsTrisomyConceptsEarly pregnancy lossAneuploid human embryosPre-implantation genetic testingHuman embryosPost-implantation developmentTrisomy 16 embryosPregnancy lossCell cycle arrestGenetic testingTrisomy 15Major causeCases of mosaicismCycle arrestE-cadherinTrisomy 21 embryosProtein E-cadherinHigh rateCommon aneuploidiesStem cellsPremature differentiationAbnormal numberAneuploidyCell adhesion protein E-cadherinDevelopmental potentialArrest