2022
Follicular activation in women previously diagnosed with poor ovarian response: a randomized, controlled trial
Díaz-García C, Herraiz S, Pamplona L, Subirá J, Soriano MJ, Simon C, Seli E, Pellicer A. Follicular activation in women previously diagnosed with poor ovarian response: a randomized, controlled trial. Fertility And Sterility 2022, 117: 747-755. PMID: 35367015, DOI: 10.1016/j.fertnstert.2021.12.034.Peer-Reviewed Original ResearchConceptsPoor ovarian responseAntral follicle countOvarian reserve markersLive birth rateOvarian fragmentationFollicular activationFollicle countOvarian responseReserve markersHormone levelsPregnancy rateReproductive outcomesEmbryo transferTotal antral follicle countMII oocytesSerum antimüllerian hormoneAntimüllerian hormone levelsBirth rateMetaphase II oocytesEmbryology (ESHRE) criteriaHippo pathway inhibitionAntimüllerian hormoneSecondary outcomesFertilization cyclesIVF outcomes
2020
A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy assay and impact of biopsy
Tiegs AW, Tao X, Zhan Y, Whitehead C, Kim J, Hanson B, Osman E, Kim TJ, Patounakis G, Gutmann J, Castelbaum A, Seli E, Jalas C, Scott RT. A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy assay and impact of biopsy. Fertility And Sterility 2020, 115: 627-637. PMID: 32863013, DOI: 10.1016/j.fertnstert.2020.07.052.Peer-Reviewed Original ResearchConceptsPreimplantation genetic testingSustained implantationPredictive valueGenetic testingClinical outcomesTrophectoderm biopsyAge-matched control groupImpact of biopsyPGT-A resultsAntral follicle countRecurrent pregnancy lossBody mass indexDetectable adverse impactAneuploid resultsSecondary outcomesFertilization cyclesFollicle countPrimary outcomeMass indexUsable blastocystsBlastocyst transferFertility centerPregnancy lossClinical error ratesStudy groupEffects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency
Cakiroglu Y, Saltik A, Yuceturk A, Karaosmanoglu O, Kopuk SY, Scott RT, Tiras B, Seli E. Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency. Aging 2020, 12: 10211-10222. PMID: 32507764, PMCID: PMC7346073, DOI: 10.18632/aging.103403.Peer-Reviewed Original ResearchConceptsAutologous platelet-rich plasmaPrimary ovarian insufficiencyPlatelet-rich plasmaIVF outcome parametersAntral follicle countIntraovarian injectionOvarian reservePRP injectionAntimullerian hormoneOutcome parametersOvarian insufficiencyRich plasmaSerum antimullerian hormoneUnderwent embryo transferExperimental treatment optionsESHRE criteriaSustained implantationOvarian stimulationSerum follicleFollicle countPRP treatmentTreatment optionsFertilization outcomeAntral folliclesEmbryo transfer
2019
Cumulus cells have longer telomeres than leukocytes in reproductive-age women
Lara-Molina EE, Franasiak JM, Marin D, Tao X, Díaz-Gimeno P, Florensa M, Martin M, Seli E, Pellicer A. Cumulus cells have longer telomeres than leukocytes in reproductive-age women. Fertility And Sterility 2019, 113: 217-223. PMID: 31594634, DOI: 10.1016/j.fertnstert.2019.08.089.Peer-Reviewed Original ResearchConceptsLeukocyte telomere lengthGranulosa cellsCumulus cellsTelomere lengthAssisted reproductive technology centerRelative leukocyte telomere lengthProspective noninterventional studyAntimüllerian hormone levelsAntral follicle countReproductive-age womenReproductive technology centerLonger telomeresNoninterventional studyFollicle countMean ageHormone levelsFollicular environmentMAIN OUTCOMEMature folliclesStudy subjectsSignificant associationFollicular cellsMean numberMature oocytesSignificant differences