2024
Mitochondria as determinants of reproductive senescence and competence: implications for diagnosis of embryo competence in assisted reproduction
Yildirim R, Seli E. Mitochondria as determinants of reproductive senescence and competence: implications for diagnosis of embryo competence in assisted reproduction. Human Reproduction 2024, 39: 2160-2170. PMID: 39066612, DOI: 10.1093/humrep/deae171.Peer-Reviewed Original ResearchMultiple quality control mechanismsMitochondrial unfolded protein responseMitochondrial DNA copy numberUnfolded protein responseQuality control mechanismsDNA copy numberMitochondrial networkRegulate calcium signalingMitochondrial dynamicsReproductive successMitochondrial quantityProtein responseDinucleotide contentModulate apoptosisOxidative phosphorylationCellular pathwaysCopy numberMitochondrial dysfunctionMitochondriaCalcium signalingEmbryo competenceMembrane potentialAssisted reproductionDiagnostic targetsReproductive senescenceMitochondria as therapeutic targets in assisted reproduction
Yildirim R, Seli E. Mitochondria as therapeutic targets in assisted reproduction. Human Reproduction 2024, 39: 2147-2159. PMID: 39066614, DOI: 10.1093/humrep/deae170.Peer-Reviewed Original ResearchMitochondrial replacement therapyClinical trialsAssisted reproductionImprove oocyte qualityTherapeutic targetAssisted reproductive outcomesImprove assisted reproductive outcomesMitochondrial quality control mechanismsDevelopmental competenceOocyte qualityReplacement therapyProgrammed cell deathQuality control mechanismsPharmacological agentsTargeting mitochondrial functionCalcium homeostasisReproductive outcomesInhibitor rapamycinMammalian targetMaternal spindle transferAntioxidant coenzyme Q10Mitochondrial populationEmbryo developmentCoenzyme Q10Cell death
2019
The association between assisted reproductive technologies and low birth weight.
Reig A, Seli E. The association between assisted reproductive technologies and low birth weight. Current Opinion In Obstetrics & Gynecology 2019, 31: 183-187. PMID: 30893135, DOI: 10.1097/gco.0000000000000535.Peer-Reviewed Original ResearchConceptsLow birth weightFresh embryo transferFrozen embryo transferBirth weightNumber of embryosEmbryo transferReproductive technologiesART-conceived pregnanciesComparable birth weightMain risk factorsEndometrial preparationPerinatal outcomesMultiple gestationsRisk factorsAssisted reproductionPrematurityNewbornsIncidenceRecent studiesPregnancyGestationWeight
2016
Same-sex reproduction
Greenfeld DA, Seli E. Same-sex reproduction. Current Opinion In Obstetrics & Gynecology 2016, 28: 202-205. PMID: 27077473, DOI: 10.1097/gco.0000000000000266.Peer-Reviewed Original ResearchConceptsSame-sex couplesSame-sex reproductionGay menPublic acceptanceSame-sex marriageSame-sex relationshipsSame-sex unionsHeterosexual parentsGay couplesHeterosexual couplesParenthoodHistorical significanceGreat endeavorNumber of menFertility treatment centreAssisted reproductionLesbiansGayWomenMarriageUnionAcceptanceRelationship satisfactionCouplesPositive functioning
2010
Assisted reproduction in a patient with Klippel-Trenaunay syndrome: management of thrombophilia and consumptive coagulopathy
Martin JR, Pels SG, Paidas M, Seli E. Assisted reproduction in a patient with Klippel-Trenaunay syndrome: management of thrombophilia and consumptive coagulopathy. Journal Of Assisted Reproduction And Genetics 2010, 28: 217-219. PMID: 21188495, PMCID: PMC3082665, DOI: 10.1007/s10815-010-9526-0.Peer-Reviewed Original ResearchConceptsKlippel-Trenaunay syndromeConsumptive coagulopathyChronic consumptive coagulopathyManagement of thrombophiliaDeep venous thrombosisExtensive port-wine stainsPort-wine stainsObstetrical riskThromboembolic eventsVenous thrombosisBone hypertrophyLymphatic malformationsCongenital malformationsSoft tissueAssisted reproductionCoagulopathyWine stainsPregnancyPatientsSyndromeMalformationsGestational surrogatesHypercoagulabilityThrombosisComplicationsGay men choosing parenthood through assisted reproduction: medical and psychosocial considerations
Greenfeld DA, Seli E. Gay men choosing parenthood through assisted reproduction: medical and psychosocial considerations. Fertility And Sterility 2010, 95: 225-229. PMID: 20643400, DOI: 10.1016/j.fertnstert.2010.05.053.Peer-Reviewed Original ResearchPerspectives on emerging biomarkers for non-invasive assessment of embryo viability in assisted reproduction.
Aydiner F, Yetkin CE, Seli E. Perspectives on emerging biomarkers for non-invasive assessment of embryo viability in assisted reproduction. 2010, 10: 206-15. PMID: 20196727, DOI: 10.2174/156652410790963349.Peer-Reviewed Original Research
2004
The presence of abnormal spermatozoa in the ejaculate: Did apoptosis fail?
Sakkas D, Seli E, Manicardi GC, Nijs M, Ombelet W, Bizzaro D. The presence of abnormal spermatozoa in the ejaculate: Did apoptosis fail? Human Fertility 2004, 7: 99-103. PMID: 15223758, DOI: 10.1080/14647270410001720464.Peer-Reviewed Original ResearchConceptsIntracytoplasmic sperm injectionNuclear DNA strand breaksDNA strand breaksAbnormal semen parametersAbnormal spermatozoaInfertile couplesMale infertilitySperm injectionSemen parametersQuality of spermatozoaAssisted reproductionStrand breaksCertain causesHuman spermatozoaSuch spermApoptosisSuccessful useNumerous studiesSpermatozoaPatients