Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer
Seli E, Vergouw CG, Morita H, Botros L, Roos P, Lambalk CB, Yamashita N, Kato O, Sakkas D. Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer. Fertility And Sterility 2009, 94: 535-542. PMID: 19589524, DOI: 10.1016/j.fertnstert.2009.03.078.Peer-Reviewed Original ResearchConceptsSingle embryo transferDay 3 embryosDay 2Embryo transferImplantation rateEmbryo culture mediumMetabolomic profilingPositive fetal cardiac activityAssisted reproductive technology programViability indexNoninvasive metabolomic profilingFetal cardiac activityReproductive technology programHuman embryo culture mediaRetrospective studyMAIN OUTCOMEDay 3Morphology gradeBlinded analysisCardiac activityReproductive potentialEmbryo assessmentCulture mediumBlinded validationWomen