2024
Does Recurrent Implantation Failure Exist? Prevalence and Outcomes of Five Consecutive Euploid Blastocyst Transfers in 123 987 Patients
Gill P, Ata B, Arnanz A, Cimadomo D, Vaiarelli A, Fatemi H, Ubaldi F, Garcia-Velasco J, Seli E. Does Recurrent Implantation Failure Exist? Prevalence and Outcomes of Five Consecutive Euploid Blastocyst Transfers in 123 987 Patients. Obstetrical & Gynecological Survey 2024, 79: 473-474. DOI: 10.1097/ogx.0000000000001310.Peer-Reviewed Original ResearchReply: Consecutive euploid blastocyst transfers currently represent the best available model for investigating the true prevalence of recurrent implantation failure (RIF), a rare pathology at best
Ata B, Gill P, Cimadomo D, Ubaldi F, Garcia-Velasco J, Seli E. Reply: Consecutive euploid blastocyst transfers currently represent the best available model for investigating the true prevalence of recurrent implantation failure (RIF), a rare pathology at best. Human Reproduction 2024, 39: 1575-1576. PMID: 38741229, DOI: 10.1093/humrep/deae096.Peer-Reviewed Original ResearchDoes recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123 987 patients
Gill P, Ata B, Arnanz A, Cimadomo D, Vaiarelli A, Fatemi H, Ubaldi F, Garcia-Velasco J, Seli E. Does recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123 987 patients. Human Reproduction 2024, 39: 974-980. PMID: 38452358, DOI: 10.1093/humrep/deae040.Peer-Reviewed Original ResearchEuploid blastocyst transferLive birth rateCumulative live birth rateBlastocyst transferEmbryo transferEuploid blastocystsImplant failureBirth ratePreimplantation genetic testing cyclesMulti-center retrospective studyDay of embryo transferCongenital uterine anomaliesEuploid embryo transferComprehensive chromosome screeningEndometrial preparation protocolsNon-obstructive azoospermiaModified natural cyclePositive pregnancy testOvarian stimulation protocolsRecurrent implantation failureParental karyotype abnormalitiesChromosome copy numberEuploid transfersTrophectoderm biopsyUterine anomalies
2021
Individual culture leads to decreased blastocyst formation but does not affect pregnancy outcomes in the setting of a single, vitrified-warmed euploid blastocyst transfer
Glatthorn HN, Hanson BM, Kim JG, Herlihy NS, Klimczak AM, Hong KH, Seli E, Scott RT. Individual culture leads to decreased blastocyst formation but does not affect pregnancy outcomes in the setting of a single, vitrified-warmed euploid blastocyst transfer. Journal Of Assisted Reproduction And Genetics 2021, 38: 2157-2164. PMID: 34086147, PMCID: PMC8417170, DOI: 10.1007/s10815-021-02252-8.Peer-Reviewed Original ResearchConceptsEuploid blastocyst transferIntracytoplasmic sperm injectionPregnancy outcomesBlastocyst transferSignificant differencesBlastocyst formationSingle embryo transferMann-Whitney U testPreimplantation genetic testingLogistic regression modelsOvarian stimulationClinical miscarriageEuploid blastocystsSperm injectionEuploid embryosEmbryo transferTrophectoderm biopsyGenetic testingGroup embryo cultureU testSame time frameDecreased rateOutcomesMiscarriageFertilization rate
2020
A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy assay and impact of biopsy
Tiegs AW, Tao X, Zhan Y, Whitehead C, Kim J, Hanson B, Osman E, Kim TJ, Patounakis G, Gutmann J, Castelbaum A, Seli E, Jalas C, Scott RT. A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy assay and impact of biopsy. Fertility And Sterility 2020, 115: 627-637. PMID: 32863013, DOI: 10.1016/j.fertnstert.2020.07.052.Peer-Reviewed Original ResearchConceptsPreimplantation genetic testingSustained implantationPredictive valueGenetic testingClinical outcomesTrophectoderm biopsyAge-matched control groupImpact of biopsyPGT-A resultsAntral follicle countRecurrent pregnancy lossBody mass indexDetectable adverse impactAneuploid resultsSecondary outcomesFertilization cyclesFollicle countPrimary outcomeMass indexUsable blastocystsBlastocyst transferFertility centerPregnancy lossClinical error ratesStudy group