2010
Receiver operating characteristic (ROC) analysis of day 5 morphology grading and metabolomic Viability Score on predicting implantation outcome
Seli E, Bruce C, Botros L, Henson M, Roos P, Judge K, Hardarson T, Ahlström A, Harrison P, Henman M, Go K, Acevedo N, Siques J, Tucker M, Sakkas D. Receiver operating characteristic (ROC) analysis of day 5 morphology grading and metabolomic Viability Score on predicting implantation outcome. Journal Of Assisted Reproduction And Genetics 2010, 28: 137-144. PMID: 21063765, PMCID: PMC3059520, DOI: 10.1007/s10815-010-9501-9.Peer-Reviewed Original ResearchConceptsSingle embryo transferFetal cardiac activityMorphologic gradingViability scoreWeeks of gestationPregnancy outcomesIVF outcomesIVF centerCharacteristic analysisMorphology gradingImplantation outcomesEmbryo transferDay 5ResultsThe areaConclusionsOur findingsPregnancyEmbryo culture medium samplesCardiac activityComposite scoreScoresCleavage rateOutcomesCulture medium samplesEmbryo morphologyGrading
2009
Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer
Seli E, Vergouw CG, Morita H, Botros L, Roos P, Lambalk CB, Yamashita N, Kato O, Sakkas D. Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer. Fertility And Sterility 2009, 94: 535-542. PMID: 19589524, DOI: 10.1016/j.fertnstert.2009.03.078.Peer-Reviewed Original ResearchConceptsSingle embryo transferDay 3 embryosDay 2Embryo transferImplantation rateEmbryo culture mediumMetabolomic profilingPositive fetal cardiac activityAssisted reproductive technology programViability indexNoninvasive metabolomic profilingFetal cardiac activityReproductive technology programHuman embryo culture mediaRetrospective studyMAIN OUTCOMEDay 3Morphology gradeBlinded analysisCardiac activityReproductive potentialEmbryo assessmentCulture mediumBlinded validationWomen