2006
Estradiol Increases Apoptosis in Human Coronary Artery Endothelial Cells by Up-Regulating Fas and Fas Ligand Expression
Seli E, Guzeloglu-Kayisli O, Cakmak H, Kayisli UA, Selam B, Arici A. Estradiol Increases Apoptosis in Human Coronary Artery Endothelial Cells by Up-Regulating Fas and Fas Ligand Expression. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4995-5001. PMID: 17003091, DOI: 10.1210/jc.2006-1225.Peer-Reviewed Original ResearchConceptsHuman coronary artery endothelial cellsCultured human coronary artery endothelial cellsHormone replacement therapyCoronary artery endothelial cellsArtery endothelial cellsReplacement therapyE2 treatmentPlaque stabilityPostmenopausal hormone replacement therapyEndothelial cellsFas/FasL pathwayEffects of E2Effects of estrogenAtherosclerotic plaque formationSignificant concentration-dependent increaseConcentration-dependent increaseFas ligand expressionCardiovascular eventsCardioprotective effectsInhibits atherogenesisMAIN OUTCOMEAnimal modelsFasL pathwayUp-regulating FasLigand expression
2002
Should patients with polycystic ovarian syndrome be treated with metformin?
Seli E, Duleba AJ. Should patients with polycystic ovarian syndrome be treated with metformin? Human Reproduction 2002, 17: 2230-2236. PMID: 12202407, DOI: 10.1093/humrep/17.9.2230.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeTreatment of PCOSInsulin-lowering agentsOvarian syndromePathogenesis of PCOSType 2 diabetes mellitusPromising therapeutic profileEarly spontaneous miscarriageOral antihyperglycaemic agentsInsulin-sensitizing drugsType 2 diabetesRisk of developmentImportant aetiologic factorPlasminogen activator inhibitorSerum lipidsDiabetes mellitusCardioprotective effectsAetiologic factorsAntihyperglycaemic agentsInsulin resistanceSpontaneous miscarriageMetforminTherapeutic profileActivator inhibitorTreatment