2021
Cumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genes
Tiegs AW, Titus S, Mehta S, Garcia-Milian R, Seli E, Scott RT. Cumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genes. Reproductive BioMedicine Online 2021, 43: 614-626. PMID: 34417138, DOI: 10.1016/j.rbmo.2021.06.015.Peer-Reviewed Original ResearchConceptsSerum response factorCumulus cellsDifferential gene expressionRNA sequencing analysisGene expression analysisIngenuity Pathway AnalysisCellular communication network factor 1Embryo developmental competenceExpression analysisPreimplantation embryo qualityGene expressionPathway analysisSegment polarity protein 2Sequencing analysisGenesProtein 2Response factorTrisomy 21Factor 1Developmental competenceAneuploid embryosReal-time polymerase chain reaction assaysDevelopment of biomarkersEmbryosCells
2020
Mitochondrial Stress Response Gene Clpp Is Not Required for Granulosa Cell Function
Esencan E, Cozzolino M, Imamoglu G, Seli E. Mitochondrial Stress Response Gene Clpp Is Not Required for Granulosa Cell Function. Antioxidants 2020, 10: 1. PMID: 33374937, PMCID: PMC7821922, DOI: 10.3390/antiox10010001.Peer-Reviewed Original ResearchMitochondrial unfolded protein responseUnfolded mitochondrial proteinsLoss of ClpPGerminal vesicleUnfolded protein responseCell functionCumulus cell functionGranulosa/cumulus cellsMitochondrial proteinsClpP deletionClpPProtein responseGermline deletionMetabolic stressGranulosa cell functionDeletionUPRCumulus cellsMice resultsSimilar numberMII oocytesFemale miceWild-type miceEarly antralCells
2013
mRNA-Binding Protein ZFP36 Is Expressed in Atherosclerotic Lesions and Reduces Inflammation in Aortic Endothelial Cells
Zhang H, Taylor WR, Joseph G, Caracciolo V, Gonzales DM, Sidell N, Seli E, Blackshear PJ, Kallen CB. mRNA-Binding Protein ZFP36 Is Expressed in Atherosclerotic Lesions and Reduces Inflammation in Aortic Endothelial Cells. Arteriosclerosis Thrombosis And Vascular Biology 2013, 33: 1212-1220. PMID: 23559629, PMCID: PMC3844532, DOI: 10.1161/atvbaha.113.301496.Peer-Reviewed Original ResearchConceptsVascular endothelial cellsEndothelial cellsAortic endothelial cellsAtherosclerotic lesionsFoam cellsAnti-inflammatory effectsHuman aortic endothelial cellsNuclear factor-κB transcriptional activationLow-density lipoproteinMacrophage foam cellsZinc finger protein 36Vascular inflammationAngiotensin IIInflammatory cytokinesCytokine mRNAZFP36 expressionBacterial lipopolysaccharideHealthy aortaInflammationTarget cellsLesionsZFP36Protein 36CellsMRNA transcripts
2006
Stem cells and fertility: what does the future hold?
Kayisli UA, Seli E. Stem cells and fertility: what does the future hold? Current Opinion In Obstetrics & Gynecology 2006, 18: 338-343. PMID: 16735836, DOI: 10.1097/01.gco.0000193008.88652.23.Peer-Reviewed Original ResearchConceptsAdult miceStem cellsFetal ovarian developmentFertility preservationOocyte formationBone marrowClinical implicationsMammalian ovariesReproductive lifeInitial reportGenerations of oocytesScientific evidenceMiceRecent findingsOocytesNew oocytesCellsOvarian developmentProminent investigatorsTotal numberFindingsInvestigators
1998
Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells.
Bahtiyar MO, Seli E, Oral E, Senturk LM, Zreik TG, Arici A. Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells. Human Reproduction 1998, 13: 3492-3495. PMID: 9886538, DOI: 10.1093/humrep/13.12.3492.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsFollicular fluidPeritoneal fluidEndometrial cellsCell proliferationStromal cellsEndometrial stromal cell culturesFollicular fluid contentEndometrial cell proliferationOocyte retrievalStromal cell culturesPeritoneal environmentCell proliferation assaysEndometriosisGrowth-promoting factorsGrowth-promoting effectProliferation assaysWomenMaximum cell proliferationProliferationCellsCell culturesHigher cell proliferationFluid content