2024
Does recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123 987 patients
Gill P, Ata B, Arnanz A, Cimadomo D, Vaiarelli A, Fatemi H, Ubaldi F, Garcia-Velasco J, Seli E. Does recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123 987 patients. Human Reproduction 2024, 39: 974-980. PMID: 38452358, DOI: 10.1093/humrep/deae040.Peer-Reviewed Original ResearchEuploid blastocyst transferLive birth rateCumulative live birth rateBlastocyst transferEmbryo transferEuploid blastocystsImplant failureBirth ratePreimplantation genetic testing cyclesMulti-center retrospective studyDay of embryo transferCongenital uterine anomaliesEuploid embryo transferComprehensive chromosome screeningEndometrial preparation protocolsNon-obstructive azoospermiaModified natural cyclePositive pregnancy testOvarian stimulation protocolsRecurrent implantation failureParental karyotype abnormalitiesChromosome copy numberEuploid transfersTrophectoderm biopsyUterine anomalies
2022
The chances of obtaining a euploid embryo and subsequent live birth remain consistent with national age-based rates after an in vitro fertilization cycle that produced only aneuploid embryos
Herlihy NS, Klimczak AM, Cheung JKW, Seli E, Scott RT. The chances of obtaining a euploid embryo and subsequent live birth remain consistent with national age-based rates after an in vitro fertilization cycle that produced only aneuploid embryos. Fertility And Sterility 2022, 118: 484-491. PMID: 35691719, DOI: 10.1016/j.fertnstert.2022.05.026.Peer-Reviewed Original ResearchConceptsLive birth rateAge groupsEuploid embryosAneuploid embryosFertilization cyclesCumulative live birth rateBirth rateYoung womenAge-appropriate counselingInitial IVF cycleSecond IVF attemptRetrospective cohort studyPercentage of patientsPrognosis of patientsFirst embryo transferSubsequent live birthAge-based standardsSame age groupPreimplantation genetic testingHigher chanceAssisted Reproductive TechnologyIVF cyclesCohort studyFavorable prognosisIVF attempts
2020
Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers
Pirtea P, De Ziegler D, Tao X, Sun L, Zhan Y, Ayoubi JM, Seli E, Franasiak JM, Scott RT. Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers. Fertility And Sterility 2020, 115: 45-53. PMID: 33077239, DOI: 10.1016/j.fertnstert.2020.07.002.Peer-Reviewed Original ResearchConceptsRecurrent implantation failureEuploid single-embryo transferLive birth rateSingle embryo transferImplantation rateImplantation failureEmbryo transferCumulative live birth rateSustained implantation ratesRetrospective cohort studyKaplan-Meier curvesReproductive technology centerDifference of outcomeBirth rateCumulative implantation rateLogistic regression modelsPositive heartbeatClinical pregnancyCohort studyMiscarriage rateMean ageEuploid blastocystsNormal uterusMAIN OUTCOMEGestational carrier