2024
Mitochondria as therapeutic targets in assisted reproduction
Yildirim R, Seli E. Mitochondria as therapeutic targets in assisted reproduction. Human Reproduction 2024, 39: 2147-2159. PMID: 39066614, DOI: 10.1093/humrep/deae170.Peer-Reviewed Original ResearchMitochondrial replacement therapyClinical trialsAssisted reproductionImprove oocyte qualityTherapeutic targetAssisted reproductive outcomesImprove assisted reproductive outcomesMitochondrial quality control mechanismsDevelopmental competenceOocyte qualityReplacement therapyProgrammed cell deathQuality control mechanismsPharmacological agentsTargeting mitochondrial functionCalcium homeostasisReproductive outcomesInhibitor rapamycinMammalian targetMaternal spindle transferAntioxidant coenzyme Q10Mitochondrial populationEmbryo developmentCoenzyme Q10Cell death
2021
Cumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genes
Tiegs AW, Titus S, Mehta S, Garcia-Milian R, Seli E, Scott RT. Cumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genes. Reproductive BioMedicine Online 2021, 43: 614-626. PMID: 34417138, DOI: 10.1016/j.rbmo.2021.06.015.Peer-Reviewed Original ResearchConceptsSerum response factorCumulus cellsDifferential gene expressionRNA sequencing analysisGene expression analysisIngenuity Pathway AnalysisCellular communication network factor 1Embryo developmental competenceExpression analysisPreimplantation embryo qualityGene expressionPathway analysisSegment polarity protein 2Sequencing analysisGenesProtein 2Response factorTrisomy 21Factor 1Developmental competenceAneuploid embryosReal-time polymerase chain reaction assaysDevelopment of biomarkersEmbryosCells