2020
Developmental potential of aneuploid human embryos cultured beyond implantation
Shahbazi MN, Wang T, Tao X, Weatherbee BAT, Sun L, Zhan Y, Keller L, Smith GD, Pellicer A, Scott RT, Seli E, Zernicka-Goetz M. Developmental potential of aneuploid human embryos cultured beyond implantation. Nature Communications 2020, 11: 3987. PMID: 32778678, PMCID: PMC7418029, DOI: 10.1038/s41467-020-17764-7.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyAntigens, CDCadherinsCell AdhesionCell Cycle CheckpointsCell LineageChromosome SegregationChromosomes, Human, Pair 16Chromosomes, Human, Pair 21Embryo ImplantationEmbryo, MammalianEmbryonic DevelopmentFemaleGenes, erbB-1Genetic TestingHumansMonosomyMosaicismPregnancyStem CellsTrisomyConceptsEarly pregnancy lossAneuploid human embryosPre-implantation genetic testingHuman embryosPost-implantation developmentTrisomy 16 embryosPregnancy lossCell cycle arrestGenetic testingTrisomy 15Major causeCases of mosaicismCycle arrestE-cadherinTrisomy 21 embryosProtein E-cadherinHigh rateCommon aneuploidiesStem cellsPremature differentiationAbnormal numberAneuploidyCell adhesion protein E-cadherinDevelopmental potentialArrest
2014
Metabolomic Assessment of Embryo Viability
Uyar A, Seli E. Metabolomic Assessment of Embryo Viability. Seminars In Reproductive Medicine 2014, 32: 141-152. PMID: 24515909, PMCID: PMC4109799, DOI: 10.1055/s-0033-1363556.Peer-Reviewed Original ResearchConceptsSingle embryo transferClinical pregnancyInitial promising resultsPreimplantation embryo metabolismPregnancy rateEmbryo selection processEmbryo viabilityEmbryo transferImplantation potentialSignificant associationConsistent benefitElimination of factorsConsecutive studiesClinical IVF laboratoryMetabolomic assessmentSuccess rateIVF laboratoryCulture mediumInconsistent findingsEmbryo metabolismMetabolomics studiesMetabolomics technologyDevelopmental potentialPrincipal studiesMedia metabolites